Burden of lung cancer and predicted costs of occupational exposure to hexavalent chromium in the EU

Detalhes bibliográficos
Autor(a) principal: Chen-Xu, José
Data de Publicação: 2023
Outros Autores: Jakobsen, Lea Sletting, Pires, Sara Monteiro, Viegas, Susana
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/152053
Resumo: Funding Information: This project received funding from the COST Action CA18218 European Burden of Disease Network, supporting the first author with a Short-Term Scientific Mission to the National Food Institute, Technical University of Denmark, with the aim of improving knowledge and applying the appropriate methodology on burden of disease on this project.The authors would like to thank the researchers from the Research Group for Risk Benefit from the National Food Institute, Technical University of Denmark for raising questions to improve the robustness of the research project, as well as the COST Action CA18218 European Burden of Disease Network for funding and supporting the project, and to the researchers Carla Martins from NOVA National School of Public Health and Ricardo Assunção from Egas Moniz Cooperativa de Ensino Superior for contributing to the initial brainstorming on the disease pathology. Publisher Copyright: © 2023 The Authors
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spelling Burden of lung cancer and predicted costs of occupational exposure to hexavalent chromium in the EUthe impact of different occupational exposure limitsBurden of diseaseHealth costsHexavalent chromiumLung cancerOccupational exposurePublic healthBiochemistryEnvironmental Science(all)SDG 3 - Good Health and Well-beingFunding Information: This project received funding from the COST Action CA18218 European Burden of Disease Network, supporting the first author with a Short-Term Scientific Mission to the National Food Institute, Technical University of Denmark, with the aim of improving knowledge and applying the appropriate methodology on burden of disease on this project.The authors would like to thank the researchers from the Research Group for Risk Benefit from the National Food Institute, Technical University of Denmark for raising questions to improve the robustness of the research project, as well as the COST Action CA18218 European Burden of Disease Network for funding and supporting the project, and to the researchers Carla Martins from NOVA National School of Public Health and Ricardo Assunção from Egas Moniz Cooperativa de Ensino Superior for contributing to the initial brainstorming on the disease pathology. Publisher Copyright: © 2023 The AuthorsBackground: Exposure to hexavalent chromium [Cr(VI)] occurs widely in occupational settings across the EU and is associated with lung cancer. In 2025, the occupational exposure limit is set to change to 5 μg/m3. Current exposure limits are higher, with 10 μg/m3 as a general limit and 25 μg/m3 for the welding industry. We aimed to assess the current burden of lung cancer caused by occupational exposure to Cr(VI) and to evaluate the impact of the recently established EU regulation by analysing different occupational exposure limits. Methods: Data were extracted from the literature, the Global Burden of Disease 2019) study, and Eurostat. We estimated the cases of cancer attributable to workplace exposure to Cr(VI) by combining exposure-effect relationships with exposure data, and calculated related DALYs and health costs in scenarios with different occupational exposure limits. Results: With current EU regulations, 253 cases (95%UI 250.96–255.71) of lung cancer were estimated to be caused by Cr(VI) in 2019, resulting in 4684 DALYs (95%UI 4683.57–4704.08). In case the welding industry adopted 10 μg/m3, a decrease of 43 cases and 797 DALYs from current values is expected. The predicted application of a 5 μg/m3 limit would cause a decrease of 148 cases and 2746 DALYs. Current costs are estimated to amount to 12.47 million euros/year (95%UI 10.19–453.82), corresponding to 39.97 million euros (95%UI 22.75–70.10) when considering costs per DALY. The limits implemented in 2025 would lead to a decrease of 23.35 million euros when considering DALYs, with benefits of introducing a limit value occurring after many decades. Adopting a 1 μg/m3 limit would lower costs to 1.04 million euros (95%UI 0.85–37.67) and to 3.33 million euros for DALYs (95%UI 1.89–5.84). Discussion: Assessing different scenarios with different Cr(VI) occupational exposure limits allowed to understand the impact of EU regulatory actions. These findings make a strong case for adapting even stricter exposure limits to protect workers’ health and avoid associated costs.Escola Nacional de Saúde Pública (ENSP)Comprehensive Health Research Centre (CHRC) - Pólo ENSPCentro de Investigação em Saúde Pública (CISP/PHRC)RUNChen-Xu, JoséJakobsen, Lea SlettingPires, Sara MonteiroViegas, Susana2023-04-21T22:21:43Z2023-07-012023-07-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/152053eng0013-9351PURE: 59107441https://doi.org/10.1016/j.envres.2023.115797info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:34:26Zoai:run.unl.pt:10362/152053Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:54:47.276980Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Burden of lung cancer and predicted costs of occupational exposure to hexavalent chromium in the EU
the impact of different occupational exposure limits
title Burden of lung cancer and predicted costs of occupational exposure to hexavalent chromium in the EU
spellingShingle Burden of lung cancer and predicted costs of occupational exposure to hexavalent chromium in the EU
Chen-Xu, José
Burden of disease
Health costs
Hexavalent chromium
Lung cancer
Occupational exposure
Public health
Biochemistry
Environmental Science(all)
SDG 3 - Good Health and Well-being
title_short Burden of lung cancer and predicted costs of occupational exposure to hexavalent chromium in the EU
title_full Burden of lung cancer and predicted costs of occupational exposure to hexavalent chromium in the EU
title_fullStr Burden of lung cancer and predicted costs of occupational exposure to hexavalent chromium in the EU
title_full_unstemmed Burden of lung cancer and predicted costs of occupational exposure to hexavalent chromium in the EU
title_sort Burden of lung cancer and predicted costs of occupational exposure to hexavalent chromium in the EU
author Chen-Xu, José
author_facet Chen-Xu, José
Jakobsen, Lea Sletting
Pires, Sara Monteiro
Viegas, Susana
author_role author
author2 Jakobsen, Lea Sletting
Pires, Sara Monteiro
Viegas, Susana
author2_role author
author
author
dc.contributor.none.fl_str_mv Escola Nacional de Saúde Pública (ENSP)
Comprehensive Health Research Centre (CHRC) - Pólo ENSP
Centro de Investigação em Saúde Pública (CISP/PHRC)
RUN
dc.contributor.author.fl_str_mv Chen-Xu, José
Jakobsen, Lea Sletting
Pires, Sara Monteiro
Viegas, Susana
dc.subject.por.fl_str_mv Burden of disease
Health costs
Hexavalent chromium
Lung cancer
Occupational exposure
Public health
Biochemistry
Environmental Science(all)
SDG 3 - Good Health and Well-being
topic Burden of disease
Health costs
Hexavalent chromium
Lung cancer
Occupational exposure
Public health
Biochemistry
Environmental Science(all)
SDG 3 - Good Health and Well-being
description Funding Information: This project received funding from the COST Action CA18218 European Burden of Disease Network, supporting the first author with a Short-Term Scientific Mission to the National Food Institute, Technical University of Denmark, with the aim of improving knowledge and applying the appropriate methodology on burden of disease on this project.The authors would like to thank the researchers from the Research Group for Risk Benefit from the National Food Institute, Technical University of Denmark for raising questions to improve the robustness of the research project, as well as the COST Action CA18218 European Burden of Disease Network for funding and supporting the project, and to the researchers Carla Martins from NOVA National School of Public Health and Ricardo Assunção from Egas Moniz Cooperativa de Ensino Superior for contributing to the initial brainstorming on the disease pathology. Publisher Copyright: © 2023 The Authors
publishDate 2023
dc.date.none.fl_str_mv 2023-04-21T22:21:43Z
2023-07-01
2023-07-01T00:00:00Z
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url http://hdl.handle.net/10362/152053
dc.language.iso.fl_str_mv eng
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dc.relation.none.fl_str_mv 0013-9351
PURE: 59107441
https://doi.org/10.1016/j.envres.2023.115797
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