Polyvinylpyrrolidone Nanofibers Incorporating Mesoporous Bioactive Glass for Bone Tissue Engineering

Detalhes bibliográficos
Autor(a) principal: Matos, Ricardo J. R.
Data de Publicação: 2023
Outros Autores: Silva, Jorge C., Soares, Paula I. P., Borges, João Paulo
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/158338
Resumo: Publisher Copyright: © 2023 by the authors.
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spelling Polyvinylpyrrolidone Nanofibers Incorporating Mesoporous Bioactive Glass for Bone Tissue Engineeringbone regenerationelectrospun polyvinylpyrrolidonemesoporous bioactive glasspolymeric scaffoldsBiotechnologyBioengineeringBiomaterialsBiochemistryBiomedical EngineeringMolecular MedicinePublisher Copyright: © 2023 by the authors.Composite biomaterials that combine osteoconductive and osteoinductive properties are a promising approach for bone tissue engineering (BTE) since they stimulate osteogenesis while mimicking extracellular matrix (ECM) morphology. In this context, the aim of the present research was to produce polyvinylpyrrolidone (PVP) nanofibers containing mesoporous bioactive glass (MBG) 80S15 nanoparticles. These composite materials were produced by the electrospinning technique. Design of experiments (DOE) was used to estimate the optimal electrospinning parameters to reduce average fiber diameter. The polymeric matrices were thermally crosslinked under different conditions, and the fibers’ morphology was studied using scanning electron microscopy (SEM). Evaluation of the mechanical properties of nanofibrous mats revealed a dependence on thermal crosslinking parameters and on the presence of MBG 80S15 particles inside the polymeric fibers. Degradation tests indicated that the presence of MBG led to a faster degradation of nanofibrous mats and to a higher swelling capacity. The assessment of in vitro bioactivity in simulated body fluid (SBF) was performed using MBG pellets and PVP/MBG (1:1) composites to assess if the bioactive properties of MBG 80S15 were kept when it was incorporated into PVP nanofibers. FTIR and XRD analysis along with SEM–EDS results indicated that a hydroxy-carbonate apatite (HCA) layer formed on the surface of MBG pellets and nanofibrous webs after soaking in SBF over different time periods. In general, the materials revealed no cytotoxic effects on the Saos-2 cell line. The overall results for the materials produced show the potential of the composites to be used in BTE.CENIMAT-i3N - Centro de Investigação de Materiais (Lab. Associado I3N)DCM - Departamento de Ciência dos MateriaisDF – Departamento de FísicaRUNMatos, Ricardo J. R.Silva, Jorge C.Soares, Paula I. P.Borges, João Paulo2023-09-26T22:22:10Z2023-05-172023-05-17T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article27application/pdfhttp://hdl.handle.net/10362/158338eng2313-7673PURE: 72485094https://doi.org/10.3390/biomimetics8020206info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:40:41Zoai:run.unl.pt:10362/158338Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:57:05.114019Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Polyvinylpyrrolidone Nanofibers Incorporating Mesoporous Bioactive Glass for Bone Tissue Engineering
title Polyvinylpyrrolidone Nanofibers Incorporating Mesoporous Bioactive Glass for Bone Tissue Engineering
spellingShingle Polyvinylpyrrolidone Nanofibers Incorporating Mesoporous Bioactive Glass for Bone Tissue Engineering
Matos, Ricardo J. R.
bone regeneration
electrospun polyvinylpyrrolidone
mesoporous bioactive glass
polymeric scaffolds
Biotechnology
Bioengineering
Biomaterials
Biochemistry
Biomedical Engineering
Molecular Medicine
title_short Polyvinylpyrrolidone Nanofibers Incorporating Mesoporous Bioactive Glass for Bone Tissue Engineering
title_full Polyvinylpyrrolidone Nanofibers Incorporating Mesoporous Bioactive Glass for Bone Tissue Engineering
title_fullStr Polyvinylpyrrolidone Nanofibers Incorporating Mesoporous Bioactive Glass for Bone Tissue Engineering
title_full_unstemmed Polyvinylpyrrolidone Nanofibers Incorporating Mesoporous Bioactive Glass for Bone Tissue Engineering
title_sort Polyvinylpyrrolidone Nanofibers Incorporating Mesoporous Bioactive Glass for Bone Tissue Engineering
author Matos, Ricardo J. R.
author_facet Matos, Ricardo J. R.
Silva, Jorge C.
Soares, Paula I. P.
Borges, João Paulo
author_role author
author2 Silva, Jorge C.
Soares, Paula I. P.
Borges, João Paulo
author2_role author
author
author
dc.contributor.none.fl_str_mv CENIMAT-i3N - Centro de Investigação de Materiais (Lab. Associado I3N)
DCM - Departamento de Ciência dos Materiais
DF – Departamento de Física
RUN
dc.contributor.author.fl_str_mv Matos, Ricardo J. R.
Silva, Jorge C.
Soares, Paula I. P.
Borges, João Paulo
dc.subject.por.fl_str_mv bone regeneration
electrospun polyvinylpyrrolidone
mesoporous bioactive glass
polymeric scaffolds
Biotechnology
Bioengineering
Biomaterials
Biochemistry
Biomedical Engineering
Molecular Medicine
topic bone regeneration
electrospun polyvinylpyrrolidone
mesoporous bioactive glass
polymeric scaffolds
Biotechnology
Bioengineering
Biomaterials
Biochemistry
Biomedical Engineering
Molecular Medicine
description Publisher Copyright: © 2023 by the authors.
publishDate 2023
dc.date.none.fl_str_mv 2023-09-26T22:22:10Z
2023-05-17
2023-05-17T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/158338
url http://hdl.handle.net/10362/158338
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 2313-7673
PURE: 72485094
https://doi.org/10.3390/biomimetics8020206
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 27
application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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