A pilot study on the metabolic impact of mediterranean diet in type 2 diabetes
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2021 |
| Outros Autores: | , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10362/116405 |
Resumo: | Funding: This study was supported by ERDF through the operation POCI-01-0145-ERDF-007746 funded by Programa Operacional Competitividade e Internacionalização—COMPETE2020 and by National Funds through FCT—Fundação para a Ciência e a Tecnologia within CINTESIS, R&D Unit (reference UID/IC/4255/2013) and CHRC (UIDB/04923/2020 and UIDP/04923/2020). This study was also supported by Emilio Peres grant from the Portuguese Society of Diabetology. |
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A pilot study on the metabolic impact of mediterranean diet in type 2 diabetesIs gut microbiota the key?Gut microbiotaMediterranean dietType 2 diabetesFood ScienceNutrition and DieteticsSDG 3 - Good Health and Well-beingFunding: This study was supported by ERDF through the operation POCI-01-0145-ERDF-007746 funded by Programa Operacional Competitividade e Internacionalização—COMPETE2020 and by National Funds through FCT—Fundação para a Ciência e a Tecnologia within CINTESIS, R&D Unit (reference UID/IC/4255/2013) and CHRC (UIDB/04923/2020 and UIDP/04923/2020). This study was also supported by Emilio Peres grant from the Portuguese Society of Diabetology.The Mediterranean diet (MD) has been recommended for type 2 diabetes (T2D) treatment. The impact of diet in shaping the gut microbiota is well known, particularly for MD. However, the link between MD and diabetes outcome improvement is not completely clear. This study aims to evaluate the role of microbiota modulation by a nonpharmacological intervention in patients with T2D. In this 12-week single-arm pilot study, nine participants received individual nutritional counseling sessions promoting MD. Gut microbiota, biochemical parameters, body composition, and blood pressure were assessed at baseline, 4 weeks, and 12 weeks after the intervention. Adherence to MD [assessed by Mediterranean Diet Adherence Screener (MEDAS) score] increased after the intervention. Bacterial richness increased after 4 weeks of intervention and was negatively correlated with fasting glucose levels and Homeostatic Model Assessment for Insulin Resistance (HOMA-IR). Prevotella to Bacteroides ratio also increased after 4 weeks. In contrast, glycated haemoglobin (HbA1c) and HOMA-IR were only decreased at the end of study. Alkaline phosphatase activity was assessed in fecal samples and was negatively correlated with HbA1c and positively correlated with bacterial diversity. The results of this study reinforce that MD adherence results in a better glycemic control in subjects with T2D. Changes in gut bacterial richness caused by MD adherence may be relevant in mediating the metabolic impact of this dietary intervention.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)Comprehensive Health Research Centre (CHRC) - pólo NMSCentro de Estudos de Doenças Crónicas (CEDOC)RUNIsmael, ShámilaSilvestre, Marta P.Vasques, MiguelAraújo, João R.Morais, JulianaDuarte, Maria InêsPestana, DiogoFaria, AnaPereira-Leal, José B.Vaz, JoanaRibeiro, PedroTeixeira, DianaMarques, CláudiaCalhau, Conceição2021-04-29T23:03:20Z2021-042021-04-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/116405eng1422-8599PURE: 29236827https://doi.org/10.3390/nu13041228info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T04:58:52Zoai:run.unl.pt:10362/116405Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:43:03.016594Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
A pilot study on the metabolic impact of mediterranean diet in type 2 diabetes Is gut microbiota the key? |
| title |
A pilot study on the metabolic impact of mediterranean diet in type 2 diabetes |
| spellingShingle |
A pilot study on the metabolic impact of mediterranean diet in type 2 diabetes Ismael, Shámila Gut microbiota Mediterranean diet Type 2 diabetes Food Science Nutrition and Dietetics SDG 3 - Good Health and Well-being |
| title_short |
A pilot study on the metabolic impact of mediterranean diet in type 2 diabetes |
| title_full |
A pilot study on the metabolic impact of mediterranean diet in type 2 diabetes |
| title_fullStr |
A pilot study on the metabolic impact of mediterranean diet in type 2 diabetes |
| title_full_unstemmed |
A pilot study on the metabolic impact of mediterranean diet in type 2 diabetes |
| title_sort |
A pilot study on the metabolic impact of mediterranean diet in type 2 diabetes |
| author |
Ismael, Shámila |
| author_facet |
Ismael, Shámila Silvestre, Marta P. Vasques, Miguel Araújo, João R. Morais, Juliana Duarte, Maria Inês Pestana, Diogo Faria, Ana Pereira-Leal, José B. Vaz, Joana Ribeiro, Pedro Teixeira, Diana Marques, Cláudia Calhau, Conceição |
| author_role |
author |
| author2 |
Silvestre, Marta P. Vasques, Miguel Araújo, João R. Morais, Juliana Duarte, Maria Inês Pestana, Diogo Faria, Ana Pereira-Leal, José B. Vaz, Joana Ribeiro, Pedro Teixeira, Diana Marques, Cláudia Calhau, Conceição |
| author2_role |
author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM) Comprehensive Health Research Centre (CHRC) - pólo NMS Centro de Estudos de Doenças Crónicas (CEDOC) RUN |
| dc.contributor.author.fl_str_mv |
Ismael, Shámila Silvestre, Marta P. Vasques, Miguel Araújo, João R. Morais, Juliana Duarte, Maria Inês Pestana, Diogo Faria, Ana Pereira-Leal, José B. Vaz, Joana Ribeiro, Pedro Teixeira, Diana Marques, Cláudia Calhau, Conceição |
| dc.subject.por.fl_str_mv |
Gut microbiota Mediterranean diet Type 2 diabetes Food Science Nutrition and Dietetics SDG 3 - Good Health and Well-being |
| topic |
Gut microbiota Mediterranean diet Type 2 diabetes Food Science Nutrition and Dietetics SDG 3 - Good Health and Well-being |
| description |
Funding: This study was supported by ERDF through the operation POCI-01-0145-ERDF-007746 funded by Programa Operacional Competitividade e Internacionalização—COMPETE2020 and by National Funds through FCT—Fundação para a Ciência e a Tecnologia within CINTESIS, R&D Unit (reference UID/IC/4255/2013) and CHRC (UIDB/04923/2020 and UIDP/04923/2020). This study was also supported by Emilio Peres grant from the Portuguese Society of Diabetology. |
| publishDate |
2021 |
| dc.date.none.fl_str_mv |
2021-04-29T23:03:20Z 2021-04 2021-04-01T00:00:00Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10362/116405 |
| url |
http://hdl.handle.net/10362/116405 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
1422-8599 PURE: 29236827 https://doi.org/10.3390/nu13041228 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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