Demystifying molecular techniques in cytopathology practice

Detalhes bibliográficos
Autor(a) principal: Schmitt, Fernando C.
Data de Publicação: 2008
Outros Autores: Longatto Filho, Adhemar, Valent, Alexander, Vielh, Philippe
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/7899
Resumo: The last decade was stimulating with the introduction of new molecular techniques to be applied in pathology laboratories. Accordingly, cytology was also benefited with the innovations emerged from this new era. Molecular cytopathology (MCP) can be defined as molecular studies applied on all types of cytological specimens, namely gynaecology cytology, exfoliative non-gyn cytology and fine needle aspirates. The development of a huge amount of new ancillary techniques has paralleled the emergence of clinical cytology as a major diagnostic speciality. Clinical applications of these techniques have been growing in the last decade. The widespread acceptance of liquid-based systems in gynaecological cytology is a paramount episode which re-draws the relation between cells and molecules. The stretched use of approaches, morphology and molecular biology, in HPV-induced lesions settings, e.g., revealed a potential to optimize, in one single brushed sample, diagnosis and research. Cytology samples from serous effusions, pulmonary tree, bladder urine, and aspirations, among others, are now likely to be studied by different molecular techniques for helping in diagnosis, prognosis, or even to assess therapeutic targets. In this review, we highlight the main results already published concerning the application of molecular techniques in different fields of cytopathology and discuss their application.
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spelling Demystifying molecular techniques in cytopathology practiceCytopathologyMolecular biologyFISHFNAThe last decade was stimulating with the introduction of new molecular techniques to be applied in pathology laboratories. Accordingly, cytology was also benefited with the innovations emerged from this new era. Molecular cytopathology (MCP) can be defined as molecular studies applied on all types of cytological specimens, namely gynaecology cytology, exfoliative non-gyn cytology and fine needle aspirates. The development of a huge amount of new ancillary techniques has paralleled the emergence of clinical cytology as a major diagnostic speciality. Clinical applications of these techniques have been growing in the last decade. The widespread acceptance of liquid-based systems in gynaecological cytology is a paramount episode which re-draws the relation between cells and molecules. The stretched use of approaches, morphology and molecular biology, in HPV-induced lesions settings, e.g., revealed a potential to optimize, in one single brushed sample, diagnosis and research. Cytology samples from serous effusions, pulmonary tree, bladder urine, and aspirations, among others, are now likely to be studied by different molecular techniques for helping in diagnosis, prognosis, or even to assess therapeutic targets. In this review, we highlight the main results already published concerning the application of molecular techniques in different fields of cytopathology and discuss their application.BMJ Publishing GroupUniversidade do MinhoSchmitt, Fernando C.Longatto Filho, AdhemarValent, AlexanderVielh, Philippe2008-032008-03-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/7899eng"Journal of Clinical Pathology". ISSN 0021-9746. 61:3 (Mar. 2008) 258-267.0021-9746http://jcp.bmj.cominfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:21:21Zoai:repositorium.sdum.uminho.pt:1822/7899Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:14:38.415066Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Demystifying molecular techniques in cytopathology practice
title Demystifying molecular techniques in cytopathology practice
spellingShingle Demystifying molecular techniques in cytopathology practice
Schmitt, Fernando C.
Cytopathology
Molecular biology
FISH
FNA
title_short Demystifying molecular techniques in cytopathology practice
title_full Demystifying molecular techniques in cytopathology practice
title_fullStr Demystifying molecular techniques in cytopathology practice
title_full_unstemmed Demystifying molecular techniques in cytopathology practice
title_sort Demystifying molecular techniques in cytopathology practice
author Schmitt, Fernando C.
author_facet Schmitt, Fernando C.
Longatto Filho, Adhemar
Valent, Alexander
Vielh, Philippe
author_role author
author2 Longatto Filho, Adhemar
Valent, Alexander
Vielh, Philippe
author2_role author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Schmitt, Fernando C.
Longatto Filho, Adhemar
Valent, Alexander
Vielh, Philippe
dc.subject.por.fl_str_mv Cytopathology
Molecular biology
FISH
FNA
topic Cytopathology
Molecular biology
FISH
FNA
description The last decade was stimulating with the introduction of new molecular techniques to be applied in pathology laboratories. Accordingly, cytology was also benefited with the innovations emerged from this new era. Molecular cytopathology (MCP) can be defined as molecular studies applied on all types of cytological specimens, namely gynaecology cytology, exfoliative non-gyn cytology and fine needle aspirates. The development of a huge amount of new ancillary techniques has paralleled the emergence of clinical cytology as a major diagnostic speciality. Clinical applications of these techniques have been growing in the last decade. The widespread acceptance of liquid-based systems in gynaecological cytology is a paramount episode which re-draws the relation between cells and molecules. The stretched use of approaches, morphology and molecular biology, in HPV-induced lesions settings, e.g., revealed a potential to optimize, in one single brushed sample, diagnosis and research. Cytology samples from serous effusions, pulmonary tree, bladder urine, and aspirations, among others, are now likely to be studied by different molecular techniques for helping in diagnosis, prognosis, or even to assess therapeutic targets. In this review, we highlight the main results already published concerning the application of molecular techniques in different fields of cytopathology and discuss their application.
publishDate 2008
dc.date.none.fl_str_mv 2008-03
2008-03-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/7899
url http://hdl.handle.net/1822/7899
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv "Journal of Clinical Pathology". ISSN 0021-9746. 61:3 (Mar. 2008) 258-267.
0021-9746
http://jcp.bmj.com
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dc.publisher.none.fl_str_mv BMJ Publishing Group
publisher.none.fl_str_mv BMJ Publishing Group
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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