The predicting factors of bisphosphonate-related osteonecrosis of the jaw

Detalhes bibliográficos
Autor(a) principal: Chafai , Ghizlane
Data de Publicação: 2017
Tipo de documento: Dissertação
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10284/6187
Resumo: Osteonecrosis of the jaw (ONJ) is a main adverse effect related to Bisphosphonates (BPs). Bisphosphonates are potent inhibitors of bone resorption and are most widely prescribed drugs for the treatment of osteoporosis, and are also used in malignant bone metastases, multiple myeloma, and Paget’s disease. With increasing use, evidence is emerging that patients taking BPs are at risk of developing bisphosphonate related-osteonecrosis of the jaw (BRONJ), sometimes occurring spontaneously, but more commonly following dental extractions or oral bone surgery. However, the pathogenesis of BRONJ remains unknown. Attempts have been made to predict the development of BRONJ. The aim of this study is to review and to discuss if the biomarkers and the systematic markers of bone turnover can be used to predict the risk of BRONJ. The methodology used in the accomplishment of this work was based on a bibliographic review for the subject under study.
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spelling The predicting factors of bisphosphonate-related osteonecrosis of the jawBisphosphonatesOsteonecrosis of the jawCTXSystematic markers of bone turnoverBifosfonatosOsteonecrose da mandíbulaCTXMarcadores sistémicos de renovação ósseaDomínio/Área Científica::Ciências Médicas::Medicina ClínicaOsteonecrosis of the jaw (ONJ) is a main adverse effect related to Bisphosphonates (BPs). Bisphosphonates are potent inhibitors of bone resorption and are most widely prescribed drugs for the treatment of osteoporosis, and are also used in malignant bone metastases, multiple myeloma, and Paget’s disease. With increasing use, evidence is emerging that patients taking BPs are at risk of developing bisphosphonate related-osteonecrosis of the jaw (BRONJ), sometimes occurring spontaneously, but more commonly following dental extractions or oral bone surgery. However, the pathogenesis of BRONJ remains unknown. Attempts have been made to predict the development of BRONJ. The aim of this study is to review and to discuss if the biomarkers and the systematic markers of bone turnover can be used to predict the risk of BRONJ. The methodology used in the accomplishment of this work was based on a bibliographic review for the subject under study.Osteonecrose da mandíbula (ONJ) é um dos principais efeitos adversos relacionados com a utilização dos bifosfonatos (BPs). Os bifosfonatos são inibidores potentes da reabsorção óssea e são drogas amplamente prescritas para o tratamento da osteoporose, sendo também usadas nas metástases ósseas, mieloma múltiplo, e doença de Paget. Com o seu uso crescente, há uma crescente evidência de que os doentes que tomam BPs estão associados a um maior risco de desenvolver osteonecrose da mandíbula relacionada com bifosfonatos (BRONJ). Esta lesão surge, por vezes, de forma espontânea, ou, mais vulgarmente após extracção dentária ou cirurgia óssea oral. Apesar destas evidências, a patogénese da BRONJ permanece desconhecida. Diversos estudos têm tentado prever o desenvolvimento desta patologia. O objetivo deste estudo é analisar e discutir se os biomarcadores e os marcadores sistémicos de renovação óssea podem ser usados para prever o risco de BRONJ. A metodologia utilizada na realização deste trabalho foi baseada numa revisão bibliográfica sobre o tema em estudo.Palmeira, CarlosRepositório Institucional da Universidade Fernando PessoaChafai , Ghizlane2017-10-10T08:13:42Z2017-07-12T00:00:00Z2017-07-12T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisapplication/pdfhttp://hdl.handle.net/10284/6187201923920enginfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-09-06T02:05:35Zoai:bdigital.ufp.pt:10284/6187Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T15:43:05.216430Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv The predicting factors of bisphosphonate-related osteonecrosis of the jaw
title The predicting factors of bisphosphonate-related osteonecrosis of the jaw
spellingShingle The predicting factors of bisphosphonate-related osteonecrosis of the jaw
Chafai , Ghizlane
Bisphosphonates
Osteonecrosis of the jaw
CTX
Systematic markers of bone turnover
Bifosfonatos
Osteonecrose da mandíbula
CTX
Marcadores sistémicos de renovação óssea
Domínio/Área Científica::Ciências Médicas::Medicina Clínica
title_short The predicting factors of bisphosphonate-related osteonecrosis of the jaw
title_full The predicting factors of bisphosphonate-related osteonecrosis of the jaw
title_fullStr The predicting factors of bisphosphonate-related osteonecrosis of the jaw
title_full_unstemmed The predicting factors of bisphosphonate-related osteonecrosis of the jaw
title_sort The predicting factors of bisphosphonate-related osteonecrosis of the jaw
author Chafai , Ghizlane
author_facet Chafai , Ghizlane
author_role author
dc.contributor.none.fl_str_mv Palmeira, Carlos
Repositório Institucional da Universidade Fernando Pessoa
dc.contributor.author.fl_str_mv Chafai , Ghizlane
dc.subject.por.fl_str_mv Bisphosphonates
Osteonecrosis of the jaw
CTX
Systematic markers of bone turnover
Bifosfonatos
Osteonecrose da mandíbula
CTX
Marcadores sistémicos de renovação óssea
Domínio/Área Científica::Ciências Médicas::Medicina Clínica
topic Bisphosphonates
Osteonecrosis of the jaw
CTX
Systematic markers of bone turnover
Bifosfonatos
Osteonecrose da mandíbula
CTX
Marcadores sistémicos de renovação óssea
Domínio/Área Científica::Ciências Médicas::Medicina Clínica
description Osteonecrosis of the jaw (ONJ) is a main adverse effect related to Bisphosphonates (BPs). Bisphosphonates are potent inhibitors of bone resorption and are most widely prescribed drugs for the treatment of osteoporosis, and are also used in malignant bone metastases, multiple myeloma, and Paget’s disease. With increasing use, evidence is emerging that patients taking BPs are at risk of developing bisphosphonate related-osteonecrosis of the jaw (BRONJ), sometimes occurring spontaneously, but more commonly following dental extractions or oral bone surgery. However, the pathogenesis of BRONJ remains unknown. Attempts have been made to predict the development of BRONJ. The aim of this study is to review and to discuss if the biomarkers and the systematic markers of bone turnover can be used to predict the risk of BRONJ. The methodology used in the accomplishment of this work was based on a bibliographic review for the subject under study.
publishDate 2017
dc.date.none.fl_str_mv 2017-10-10T08:13:42Z
2017-07-12T00:00:00Z
2017-07-12T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/masterThesis
format masterThesis
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10284/6187
201923920
url http://hdl.handle.net/10284/6187
identifier_str_mv 201923920
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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