The predicting factors of bisphosphonate-related osteonecrosis of the jaw
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Tipo de documento: | Dissertação |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10284/6187 |
Resumo: | Osteonecrosis of the jaw (ONJ) is a main adverse effect related to Bisphosphonates (BPs). Bisphosphonates are potent inhibitors of bone resorption and are most widely prescribed drugs for the treatment of osteoporosis, and are also used in malignant bone metastases, multiple myeloma, and Paget’s disease. With increasing use, evidence is emerging that patients taking BPs are at risk of developing bisphosphonate related-osteonecrosis of the jaw (BRONJ), sometimes occurring spontaneously, but more commonly following dental extractions or oral bone surgery. However, the pathogenesis of BRONJ remains unknown. Attempts have been made to predict the development of BRONJ. The aim of this study is to review and to discuss if the biomarkers and the systematic markers of bone turnover can be used to predict the risk of BRONJ. The methodology used in the accomplishment of this work was based on a bibliographic review for the subject under study. |
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The predicting factors of bisphosphonate-related osteonecrosis of the jawBisphosphonatesOsteonecrosis of the jawCTXSystematic markers of bone turnoverBifosfonatosOsteonecrose da mandíbulaCTXMarcadores sistémicos de renovação ósseaDomínio/Área Científica::Ciências Médicas::Medicina ClínicaOsteonecrosis of the jaw (ONJ) is a main adverse effect related to Bisphosphonates (BPs). Bisphosphonates are potent inhibitors of bone resorption and are most widely prescribed drugs for the treatment of osteoporosis, and are also used in malignant bone metastases, multiple myeloma, and Paget’s disease. With increasing use, evidence is emerging that patients taking BPs are at risk of developing bisphosphonate related-osteonecrosis of the jaw (BRONJ), sometimes occurring spontaneously, but more commonly following dental extractions or oral bone surgery. However, the pathogenesis of BRONJ remains unknown. Attempts have been made to predict the development of BRONJ. The aim of this study is to review and to discuss if the biomarkers and the systematic markers of bone turnover can be used to predict the risk of BRONJ. The methodology used in the accomplishment of this work was based on a bibliographic review for the subject under study.Osteonecrose da mandíbula (ONJ) é um dos principais efeitos adversos relacionados com a utilização dos bifosfonatos (BPs). Os bifosfonatos são inibidores potentes da reabsorção óssea e são drogas amplamente prescritas para o tratamento da osteoporose, sendo também usadas nas metástases ósseas, mieloma múltiplo, e doença de Paget. Com o seu uso crescente, há uma crescente evidência de que os doentes que tomam BPs estão associados a um maior risco de desenvolver osteonecrose da mandíbula relacionada com bifosfonatos (BRONJ). Esta lesão surge, por vezes, de forma espontânea, ou, mais vulgarmente após extracção dentária ou cirurgia óssea oral. Apesar destas evidências, a patogénese da BRONJ permanece desconhecida. Diversos estudos têm tentado prever o desenvolvimento desta patologia. O objetivo deste estudo é analisar e discutir se os biomarcadores e os marcadores sistémicos de renovação óssea podem ser usados para prever o risco de BRONJ. A metodologia utilizada na realização deste trabalho foi baseada numa revisão bibliográfica sobre o tema em estudo.Palmeira, CarlosRepositório Institucional da Universidade Fernando PessoaChafai , Ghizlane2017-10-10T08:13:42Z2017-07-12T00:00:00Z2017-07-12T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisapplication/pdfhttp://hdl.handle.net/10284/6187201923920enginfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-09-06T02:05:35Zoai:bdigital.ufp.pt:10284/6187Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T15:43:05.216430Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
The predicting factors of bisphosphonate-related osteonecrosis of the jaw |
title |
The predicting factors of bisphosphonate-related osteonecrosis of the jaw |
spellingShingle |
The predicting factors of bisphosphonate-related osteonecrosis of the jaw Chafai , Ghizlane Bisphosphonates Osteonecrosis of the jaw CTX Systematic markers of bone turnover Bifosfonatos Osteonecrose da mandíbula CTX Marcadores sistémicos de renovação óssea Domínio/Área Científica::Ciências Médicas::Medicina Clínica |
title_short |
The predicting factors of bisphosphonate-related osteonecrosis of the jaw |
title_full |
The predicting factors of bisphosphonate-related osteonecrosis of the jaw |
title_fullStr |
The predicting factors of bisphosphonate-related osteonecrosis of the jaw |
title_full_unstemmed |
The predicting factors of bisphosphonate-related osteonecrosis of the jaw |
title_sort |
The predicting factors of bisphosphonate-related osteonecrosis of the jaw |
author |
Chafai , Ghizlane |
author_facet |
Chafai , Ghizlane |
author_role |
author |
dc.contributor.none.fl_str_mv |
Palmeira, Carlos Repositório Institucional da Universidade Fernando Pessoa |
dc.contributor.author.fl_str_mv |
Chafai , Ghizlane |
dc.subject.por.fl_str_mv |
Bisphosphonates Osteonecrosis of the jaw CTX Systematic markers of bone turnover Bifosfonatos Osteonecrose da mandíbula CTX Marcadores sistémicos de renovação óssea Domínio/Área Científica::Ciências Médicas::Medicina Clínica |
topic |
Bisphosphonates Osteonecrosis of the jaw CTX Systematic markers of bone turnover Bifosfonatos Osteonecrose da mandíbula CTX Marcadores sistémicos de renovação óssea Domínio/Área Científica::Ciências Médicas::Medicina Clínica |
description |
Osteonecrosis of the jaw (ONJ) is a main adverse effect related to Bisphosphonates (BPs). Bisphosphonates are potent inhibitors of bone resorption and are most widely prescribed drugs for the treatment of osteoporosis, and are also used in malignant bone metastases, multiple myeloma, and Paget’s disease. With increasing use, evidence is emerging that patients taking BPs are at risk of developing bisphosphonate related-osteonecrosis of the jaw (BRONJ), sometimes occurring spontaneously, but more commonly following dental extractions or oral bone surgery. However, the pathogenesis of BRONJ remains unknown. Attempts have been made to predict the development of BRONJ. The aim of this study is to review and to discuss if the biomarkers and the systematic markers of bone turnover can be used to predict the risk of BRONJ. The methodology used in the accomplishment of this work was based on a bibliographic review for the subject under study. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-10-10T08:13:42Z 2017-07-12T00:00:00Z 2017-07-12T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/masterThesis |
format |
masterThesis |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10284/6187 201923920 |
url |
http://hdl.handle.net/10284/6187 |
identifier_str_mv |
201923920 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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