Idiopathic hypocomplementaemic tubulointerstitial nephritis

Detalhes bibliográficos
Autor(a) principal: Azevedo,Ana
Data de Publicação: 2015
Outros Autores: Mesquita,Isabel, Viana,Helena, Rocha,Gizela, Ferreira,Carina, Fernandes,Vasco, Murinello,Antonio, Carvalho,Fernanda, Nolasco,Fernando
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-01692015000100012
Resumo: Background: Tubulointerstitial nephritis (TIN) is a common cause of kidney injury typically seen in association with drug exposure, infection or autoimmune diseases. However, TIN with interstitial immune complex deposition, without glomerular injury, is rarely observed. Case: We report a case of a 64-yearold Indian woman admitted for dialysis-requiring renal failure, without involvement of other organs. Urinalysis showed blood 3+ and 24h proteinuria of 1.5 g. Renal ultrasound revealed normal sized kidneys with loss of parenchymal-sinus differentiation. Laboratory tests disclosed low C3, positive ANA but negative anti-dsDNA, SSA and SSB. Serum protein electrophoresis was normal. The renal biopsy showed tubulointerstitial nephritis with positive immunoglobulin staining involving the interstitium and tubular basement membrane with glomerular sparing. The patient started prednisolone (1mg/kg/day) without recovery of the renal function. Conclusion: Idiopathic hypocomplementaemic tubulointerstitial nephritis is a rare disease with few cases described in the literature. To our knowledge this is the first case reported in Portugal
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spelling Idiopathic hypocomplementaemic tubulointerstitial nephritisHypocomplementaemiaidiopathic tubulointersticial nephritisrenal failureBackground: Tubulointerstitial nephritis (TIN) is a common cause of kidney injury typically seen in association with drug exposure, infection or autoimmune diseases. However, TIN with interstitial immune complex deposition, without glomerular injury, is rarely observed. Case: We report a case of a 64-yearold Indian woman admitted for dialysis-requiring renal failure, without involvement of other organs. Urinalysis showed blood 3+ and 24h proteinuria of 1.5 g. Renal ultrasound revealed normal sized kidneys with loss of parenchymal-sinus differentiation. Laboratory tests disclosed low C3, positive ANA but negative anti-dsDNA, SSA and SSB. Serum protein electrophoresis was normal. The renal biopsy showed tubulointerstitial nephritis with positive immunoglobulin staining involving the interstitium and tubular basement membrane with glomerular sparing. The patient started prednisolone (1mg/kg/day) without recovery of the renal function. Conclusion: Idiopathic hypocomplementaemic tubulointerstitial nephritis is a rare disease with few cases described in the literature. To our knowledge this is the first case reported in PortugalSociedade Portuguesa de Nefrologia2015-03-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articletext/htmlhttp://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-01692015000100012Portuguese Journal of Nephrology & Hypertension v.29 n.1 2015reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPenghttp://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-01692015000100012Azevedo,AnaMesquita,IsabelViana,HelenaRocha,GizelaFerreira,CarinaFernandes,VascoMurinello,AntonioCarvalho,FernandaNolasco,Fernandoinfo:eu-repo/semantics/openAccess2024-02-06T17:04:48Zoai:scielo:S0872-01692015000100012Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T02:18:54.277349Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Idiopathic hypocomplementaemic tubulointerstitial nephritis
title Idiopathic hypocomplementaemic tubulointerstitial nephritis
spellingShingle Idiopathic hypocomplementaemic tubulointerstitial nephritis
Azevedo,Ana
Hypocomplementaemia
idiopathic tubulointersticial nephritis
renal failure
title_short Idiopathic hypocomplementaemic tubulointerstitial nephritis
title_full Idiopathic hypocomplementaemic tubulointerstitial nephritis
title_fullStr Idiopathic hypocomplementaemic tubulointerstitial nephritis
title_full_unstemmed Idiopathic hypocomplementaemic tubulointerstitial nephritis
title_sort Idiopathic hypocomplementaemic tubulointerstitial nephritis
author Azevedo,Ana
author_facet Azevedo,Ana
Mesquita,Isabel
Viana,Helena
Rocha,Gizela
Ferreira,Carina
Fernandes,Vasco
Murinello,Antonio
Carvalho,Fernanda
Nolasco,Fernando
author_role author
author2 Mesquita,Isabel
Viana,Helena
Rocha,Gizela
Ferreira,Carina
Fernandes,Vasco
Murinello,Antonio
Carvalho,Fernanda
Nolasco,Fernando
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Azevedo,Ana
Mesquita,Isabel
Viana,Helena
Rocha,Gizela
Ferreira,Carina
Fernandes,Vasco
Murinello,Antonio
Carvalho,Fernanda
Nolasco,Fernando
dc.subject.por.fl_str_mv Hypocomplementaemia
idiopathic tubulointersticial nephritis
renal failure
topic Hypocomplementaemia
idiopathic tubulointersticial nephritis
renal failure
description Background: Tubulointerstitial nephritis (TIN) is a common cause of kidney injury typically seen in association with drug exposure, infection or autoimmune diseases. However, TIN with interstitial immune complex deposition, without glomerular injury, is rarely observed. Case: We report a case of a 64-yearold Indian woman admitted for dialysis-requiring renal failure, without involvement of other organs. Urinalysis showed blood 3+ and 24h proteinuria of 1.5 g. Renal ultrasound revealed normal sized kidneys with loss of parenchymal-sinus differentiation. Laboratory tests disclosed low C3, positive ANA but negative anti-dsDNA, SSA and SSB. Serum protein electrophoresis was normal. The renal biopsy showed tubulointerstitial nephritis with positive immunoglobulin staining involving the interstitium and tubular basement membrane with glomerular sparing. The patient started prednisolone (1mg/kg/day) without recovery of the renal function. Conclusion: Idiopathic hypocomplementaemic tubulointerstitial nephritis is a rare disease with few cases described in the literature. To our knowledge this is the first case reported in Portugal
publishDate 2015
dc.date.none.fl_str_mv 2015-03-01
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dc.publisher.none.fl_str_mv Sociedade Portuguesa de Nefrologia
publisher.none.fl_str_mv Sociedade Portuguesa de Nefrologia
dc.source.none.fl_str_mv Portuguese Journal of Nephrology & Hypertension v.29 n.1 2015
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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