Orthostatic Stress and Baroreflex Sensitivity
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10362/158792 |
Resumo: | Publisher Copyright: © 2023 by the authors. |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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7160 |
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Orthostatic Stress and Baroreflex SensitivityA Window into Autonomic Dysfunction in Lone Paroxysmal Atrial Fibrillationatrial fibrillationautonomic functionbaroreceptor reflexbaroreflex effectiveness indexbaroreflex gainMedicine(all)Publisher Copyright: © 2023 by the authors.The abnormal neural control of atria has been considered one of the mechanisms of paroxysmal atrial fibrillation (PAF) pathogenesis. The baroreceptor reflex has an important role in cardiovascular regulation and may serve as an index of autonomic function. This study aimed to analyze the baroreceptor reflex’s role in heart rate regulation during upright tilt (HUT) in patients with lone PAF. The study included 68 patients with lone PAF and 34 healthy individuals who underwent baroreflex assessment. Parameters such as baroreflex sensitivity (BRS), number of systolic blood pressure (BP) ramps, and the baroreflex effectiveness index (BEI) were evaluated. The study found that PAF patients had comparable resting BPs and heart rates (HRs) to healthy individuals. However, unlike healthy individuals, PAF patients showed a sustained increase in BP with an upright posture followed by the delayed activation of the baroreceptor function with a blunted HR response and lower BEI values. This indicates a pronounced baroreflex impairment in PAF patients, even at rest. Our data suggest that together with BRS, BEI could be used as a marker of autonomic dysfunction in PAF patients, making it important to further investigate its relationship with AF recurrence after ablation and its involvement in cardiovascular autonomic remodeling.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)Comprehensive Health Research Centre (CHRC) - pólo NMSRUNFerreira, MónicaLaranjo, SergioCunha, PedroGeraldes, VeraOliveira, MárioRocha, Isabel2023-10-09T22:18:33Z2023-092023-09-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/158792eng2077-0383PURE: 73492033https://doi.org/10.3390/jcm12185857info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:41:17Zoai:run.unl.pt:10362/158792Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:57:17.730827Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Orthostatic Stress and Baroreflex Sensitivity A Window into Autonomic Dysfunction in Lone Paroxysmal Atrial Fibrillation |
title |
Orthostatic Stress and Baroreflex Sensitivity |
spellingShingle |
Orthostatic Stress and Baroreflex Sensitivity Ferreira, Mónica atrial fibrillation autonomic function baroreceptor reflex baroreflex effectiveness index baroreflex gain Medicine(all) |
title_short |
Orthostatic Stress and Baroreflex Sensitivity |
title_full |
Orthostatic Stress and Baroreflex Sensitivity |
title_fullStr |
Orthostatic Stress and Baroreflex Sensitivity |
title_full_unstemmed |
Orthostatic Stress and Baroreflex Sensitivity |
title_sort |
Orthostatic Stress and Baroreflex Sensitivity |
author |
Ferreira, Mónica |
author_facet |
Ferreira, Mónica Laranjo, Sergio Cunha, Pedro Geraldes, Vera Oliveira, Mário Rocha, Isabel |
author_role |
author |
author2 |
Laranjo, Sergio Cunha, Pedro Geraldes, Vera Oliveira, Mário Rocha, Isabel |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM) Comprehensive Health Research Centre (CHRC) - pólo NMS RUN |
dc.contributor.author.fl_str_mv |
Ferreira, Mónica Laranjo, Sergio Cunha, Pedro Geraldes, Vera Oliveira, Mário Rocha, Isabel |
dc.subject.por.fl_str_mv |
atrial fibrillation autonomic function baroreceptor reflex baroreflex effectiveness index baroreflex gain Medicine(all) |
topic |
atrial fibrillation autonomic function baroreceptor reflex baroreflex effectiveness index baroreflex gain Medicine(all) |
description |
Publisher Copyright: © 2023 by the authors. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-10-09T22:18:33Z 2023-09 2023-09-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10362/158792 |
url |
http://hdl.handle.net/10362/158792 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
2077-0383 PURE: 73492033 https://doi.org/10.3390/jcm12185857 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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|
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1799138156066373632 |