A network perspective on antimicrobial peptide combination therapies: the potential of colistin, polymyxin B and nisin

Detalhes bibliográficos
Autor(a) principal: Jorge, Paula
Data de Publicação: 2017
Outros Autores: Pérez-Pérez, Martín, Rodríguez, Gael Pérez, Pereira, Maria Olívia, Lourenço, Anália
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/47483
Resumo: Supplementary data associated with this article can be found, in the online version, at doi:10.1016/j.ijantimicag.2017.02.012.
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spelling A network perspective on antimicrobial peptide combination therapies: the potential of colistin, polymyxin B and nisinAntimicrobial peptide combinationBioinformaticsNetworkColistinPolymyxin BNisinScience & TechnologySupplementary data associated with this article can be found, in the online version, at doi:10.1016/j.ijantimicag.2017.02.012.Antimicrobial combinations involving antimicrobial peptides (AMPs) attract considerable attention within current antimicrobial and anti-resistance research. The objective of this study was to review the available scientific literature on the effects of antimicrobial combinations involving colistin (polymyxin E), polymyxin B and nisin, which are US Food and Drug Administration (FDA)-approved AMPs broadly tested against prominent multidrug-resistant pathogens. A bioinformatics approach based on literature mining and manual expert curation supported the reconstruction of experimental evidence on the potential of these AMP combinations, as described in the literature. Network analysis enabled further characterisation of the retrieved antimicrobial agents, targets and combinatory effects. This systematic analysis was able to output valuable information on the studies conducted on colistin, polymyxin B and nisin combinations. The reconstructed networks enable the traversal and browsing of a large number of agent combinations, providing comprehensive details on the organisms, modes of growth and methodologies used in the studies. Therefore, network analysis enables a bird's-eye view of current research trends as well as in-depth analysis of specific drugs, organisms and combinatory effects, according to particular user interests. The reconstructed knowledge networks are publicly accessible at http://sing-group.org/antimicrobialCombination/. Hopefully, this resource will help researchers to look into antimicrobial combinations more easily and systematically. User-customised queries may help to identify missing and less studied links and to generate new research hypotheses.This work was supported by the Portuguese Foundation for Science and Technology(FCT)under the scope of the strategic funding of UID/BIO/04469/2013 unit and COMPETE 2020 [POCI01-0145-FEDER-006684] and BioTecNorte operation [NORTE-010145-FEDER-000004], funded by the European Regional Development Fund under the scope of Norte2020—Programa Operacional Regional do Norte.The authors also acknowledge the support received from FCT and the European Community fund FEDER, through Program COMPETE, under the scope of the Project RECI/BBB-EBI/0179/2012 [FCOMP-01-0124-FEDER-027462],the[14VI05]Contract-Programme from the University of Vigo (Vigo, Spain), the INOU-16-05 project from the Provincial Council of Ourense, and the Agrupamento INBIOMED from DXPCTSUG-FEDER unha maneira de facer Europa [2012/273]. SING group thanks CITI (Centro de Investigación, Transferencia e Innovación) from University of Vigo for hosting its IT infrastructure. Finally, the authors acknowledge the PhD grant of Paula Jorge[Grant no. SFRH/BD/88192/2012],funded by FCT,thePhD grants of Martín Pérez-Pérez and Gael Pérez-Rodríguez, funded by the Xunta de Galicia and the University of Vigo, and the Research grant 2014 of Anália Lourenço by the European Society of Clinical Microbiology and Infectious Diseases (ESCMID).info:eu-repo/semantics/publishedVersionElsevierUniversidade do MinhoJorge, PaulaPérez-Pérez, MartínRodríguez, Gael PérezPereira, Maria OlíviaLourenço, Anália2017-062017-06-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/47483engJorge, Paula; Pérez-Pérez, Martín; Rodríguez, Gael Pérez; Pereira, Maria Olívia; Lourenço, Anália, A network perspective on antimicrobial peptide combination therapies: the potential of colistin, polymyxin B and nisin. International Journal of Antimicrobial Agents, 49(6), 668-676, 20171872-79130924-857910.1016/j.ijantimicag.2017.02.01228457834info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:47:25Zoai:repositorium.sdum.uminho.pt:1822/47483Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:45:31.544337Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv A network perspective on antimicrobial peptide combination therapies: the potential of colistin, polymyxin B and nisin
title A network perspective on antimicrobial peptide combination therapies: the potential of colistin, polymyxin B and nisin
spellingShingle A network perspective on antimicrobial peptide combination therapies: the potential of colistin, polymyxin B and nisin
Jorge, Paula
Antimicrobial peptide combination
Bioinformatics
Network
Colistin
Polymyxin B
Nisin
Science & Technology
title_short A network perspective on antimicrobial peptide combination therapies: the potential of colistin, polymyxin B and nisin
title_full A network perspective on antimicrobial peptide combination therapies: the potential of colistin, polymyxin B and nisin
title_fullStr A network perspective on antimicrobial peptide combination therapies: the potential of colistin, polymyxin B and nisin
title_full_unstemmed A network perspective on antimicrobial peptide combination therapies: the potential of colistin, polymyxin B and nisin
title_sort A network perspective on antimicrobial peptide combination therapies: the potential of colistin, polymyxin B and nisin
author Jorge, Paula
author_facet Jorge, Paula
Pérez-Pérez, Martín
Rodríguez, Gael Pérez
Pereira, Maria Olívia
Lourenço, Anália
author_role author
author2 Pérez-Pérez, Martín
Rodríguez, Gael Pérez
Pereira, Maria Olívia
Lourenço, Anália
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Jorge, Paula
Pérez-Pérez, Martín
Rodríguez, Gael Pérez
Pereira, Maria Olívia
Lourenço, Anália
dc.subject.por.fl_str_mv Antimicrobial peptide combination
Bioinformatics
Network
Colistin
Polymyxin B
Nisin
Science & Technology
topic Antimicrobial peptide combination
Bioinformatics
Network
Colistin
Polymyxin B
Nisin
Science & Technology
description Supplementary data associated with this article can be found, in the online version, at doi:10.1016/j.ijantimicag.2017.02.012.
publishDate 2017
dc.date.none.fl_str_mv 2017-06
2017-06-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/47483
url http://hdl.handle.net/1822/47483
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Jorge, Paula; Pérez-Pérez, Martín; Rodríguez, Gael Pérez; Pereira, Maria Olívia; Lourenço, Anália, A network perspective on antimicrobial peptide combination therapies: the potential of colistin, polymyxin B and nisin. International Journal of Antimicrobial Agents, 49(6), 668-676, 2017
1872-7913
0924-8579
10.1016/j.ijantimicag.2017.02.012
28457834
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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