Sugar-lowering drugs for type 2 diabetes mellitus and metabolic syndromestrategies for in vivo administration: Part-II

Detalhes bibliográficos
Autor(a) principal: Vieira, Raquel
Data de Publicação: 2019
Outros Autores: Souto, Selma B., Sánchez-López, Elena, López Machado, Ana, Severino, Patricia, Jose, Sajan, Santini, Antonello, Silva, Amelia M., Fortuna, Ana, García, Maria Luisa, Souto, Eliana B.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/61704
Resumo: Diabetes is a complex disease characterized by hyperglycemia, together with polyuria, polydipsia, and polyphagia. While Type 1 diabetes mellitus (T1DM) results from genetic, environmental, or immune dysfunction factors leading to pancreatic ß-cell destruction depriving the organism from endogenous insulin, Type 2 diabetes mellitus (T2DM) is characterized by peripheral insulin resistance. Depending on the type of diabetes mellitus and drug mechanism to study, the animal model should be carefully selected among the wide variety of the currently available ones. This review discusses the most common animal models currently employed to study T1DM and T2DM. Moreover, an overview on the administration routes that could be used is also discussed.
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spelling Sugar-lowering drugs for type 2 diabetes mellitus and metabolic syndromestrategies for in vivo administration: Part-IIdiabetes mellitusanimal modelsin vivoadministration routesScience & TechnologyDiabetes is a complex disease characterized by hyperglycemia, together with polyuria, polydipsia, and polyphagia. While Type 1 diabetes mellitus (T1DM) results from genetic, environmental, or immune dysfunction factors leading to pancreatic ß-cell destruction depriving the organism from endogenous insulin, Type 2 diabetes mellitus (T2DM) is characterized by peripheral insulin resistance. Depending on the type of diabetes mellitus and drug mechanism to study, the animal model should be carefully selected among the wide variety of the currently available ones. This review discusses the most common animal models currently employed to study T1DM and T2DM. Moreover, an overview on the administration routes that could be used is also discussed.The authors acknowledge the financial support received from Portuguese Science and TechnologyFoundation (FCT/MCT) and from European Funds (PRODER/COMPETE) under the project referenceM-ERA-NET/0004/2015-PAIRED, co-financed by FEDER, under the Partnership Agreement PT2020. The authors also acknowledge the support of the Institute of Nanoscience and Nanotechnology under the project ART (2018).info:eu-repo/semantics/publishedVersionMultidisciplinary Digital Publishing Institute (MDPI)Universidade do MinhoVieira, RaquelSouto, Selma B.Sánchez-López, ElenaLópez Machado, AnaSeverino, PatriciaJose, SajanSantini, AntonelloSilva, Amelia M.Fortuna, AnaGarcía, Maria LuisaSouto, Eliana B.2019-08-282019-08-28T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/61704engVieira, Raquel; Souto, Selma B.; Sánchez-López, Elena; López Machado, Ana; Severino, Patricia; Jose, Sajan; Santini, Antonello; Silva, Amelia M.; Fortuna, Ana; García, Maria Luisa; Souto, Eliana, Sugar-lowering drugs for type 2 diabetes mellitus and metabolic syndromestrategies for in vivo administration: Part-II. Journal of Clinical Medicine, 8(9), 1332, 20192077-03832077-038310.3390/jcm8091332https://www.mdpi.com/journal/jcminfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:51:52Zoai:repositorium.sdum.uminho.pt:1822/61704Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:50:52.379843Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Sugar-lowering drugs for type 2 diabetes mellitus and metabolic syndromestrategies for in vivo administration: Part-II
title Sugar-lowering drugs for type 2 diabetes mellitus and metabolic syndromestrategies for in vivo administration: Part-II
spellingShingle Sugar-lowering drugs for type 2 diabetes mellitus and metabolic syndromestrategies for in vivo administration: Part-II
Vieira, Raquel
diabetes mellitus
animal models
in vivo
administration routes
Science & Technology
title_short Sugar-lowering drugs for type 2 diabetes mellitus and metabolic syndromestrategies for in vivo administration: Part-II
title_full Sugar-lowering drugs for type 2 diabetes mellitus and metabolic syndromestrategies for in vivo administration: Part-II
title_fullStr Sugar-lowering drugs for type 2 diabetes mellitus and metabolic syndromestrategies for in vivo administration: Part-II
title_full_unstemmed Sugar-lowering drugs for type 2 diabetes mellitus and metabolic syndromestrategies for in vivo administration: Part-II
title_sort Sugar-lowering drugs for type 2 diabetes mellitus and metabolic syndromestrategies for in vivo administration: Part-II
author Vieira, Raquel
author_facet Vieira, Raquel
Souto, Selma B.
Sánchez-López, Elena
López Machado, Ana
Severino, Patricia
Jose, Sajan
Santini, Antonello
Silva, Amelia M.
Fortuna, Ana
García, Maria Luisa
Souto, Eliana B.
author_role author
author2 Souto, Selma B.
Sánchez-López, Elena
López Machado, Ana
Severino, Patricia
Jose, Sajan
Santini, Antonello
Silva, Amelia M.
Fortuna, Ana
García, Maria Luisa
Souto, Eliana B.
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Vieira, Raquel
Souto, Selma B.
Sánchez-López, Elena
López Machado, Ana
Severino, Patricia
Jose, Sajan
Santini, Antonello
Silva, Amelia M.
Fortuna, Ana
García, Maria Luisa
Souto, Eliana B.
dc.subject.por.fl_str_mv diabetes mellitus
animal models
in vivo
administration routes
Science & Technology
topic diabetes mellitus
animal models
in vivo
administration routes
Science & Technology
description Diabetes is a complex disease characterized by hyperglycemia, together with polyuria, polydipsia, and polyphagia. While Type 1 diabetes mellitus (T1DM) results from genetic, environmental, or immune dysfunction factors leading to pancreatic ß-cell destruction depriving the organism from endogenous insulin, Type 2 diabetes mellitus (T2DM) is characterized by peripheral insulin resistance. Depending on the type of diabetes mellitus and drug mechanism to study, the animal model should be carefully selected among the wide variety of the currently available ones. This review discusses the most common animal models currently employed to study T1DM and T2DM. Moreover, an overview on the administration routes that could be used is also discussed.
publishDate 2019
dc.date.none.fl_str_mv 2019-08-28
2019-08-28T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/61704
url http://hdl.handle.net/1822/61704
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Vieira, Raquel; Souto, Selma B.; Sánchez-López, Elena; López Machado, Ana; Severino, Patricia; Jose, Sajan; Santini, Antonello; Silva, Amelia M.; Fortuna, Ana; García, Maria Luisa; Souto, Eliana, Sugar-lowering drugs for type 2 diabetes mellitus and metabolic syndromestrategies for in vivo administration: Part-II. Journal of Clinical Medicine, 8(9), 1332, 2019
2077-0383
2077-0383
10.3390/jcm8091332
https://www.mdpi.com/journal/jcm
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute (MDPI)
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute (MDPI)
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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