Imbalance of Steroid Hormones in Hamsters Infected with Schistosoma mansoni
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.22/15046 |
Resumo: | Objective: Schistosomiasis is a debilitating disease that affects 200 million people worldwide. Schistosoma haematobium and Schistosoma mansoni are the major causative agents of this disease. Cancer-association and infertility-association in Schistosoma haematobium infection have already been described and it is known that the parasite produces a catechol-estrogen molecule that induces a hormonal imbalance in the host. Methods: In order to better understand the relation of hormonal imbalance in experimental Schistosoma mansoni infection, we investigated a serum panel of steroid hormones in Schistosoma mansoni infected hamsters. Results: We found a decrease in the serum levels of Estradiol (E2), Testosterone and Progesterone in infected females and an increase of Testosterone and a decrease in Progesterone in infected males in comparison with controls. Conclusion: These results indicate that S. mansoni alters the levels of steroid hormones in infected males and females and it will increase the repertoire of data about the host-parasite molecular interplay and its relation with the endocrine system. |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Imbalance of Steroid Hormones in Hamsters Infected with Schistosoma mansoniSteroid hormonesSchistosoma mansoni infectionHost-parasite interactionEstradiolTestosteroneProgesteroneInfertilityObjective: Schistosomiasis is a debilitating disease that affects 200 million people worldwide. Schistosoma haematobium and Schistosoma mansoni are the major causative agents of this disease. Cancer-association and infertility-association in Schistosoma haematobium infection have already been described and it is known that the parasite produces a catechol-estrogen molecule that induces a hormonal imbalance in the host. Methods: In order to better understand the relation of hormonal imbalance in experimental Schistosoma mansoni infection, we investigated a serum panel of steroid hormones in Schistosoma mansoni infected hamsters. Results: We found a decrease in the serum levels of Estradiol (E2), Testosterone and Progesterone in infected females and an increase of Testosterone and a decrease in Progesterone in infected males in comparison with controls. Conclusion: These results indicate that S. mansoni alters the levels of steroid hormones in infected males and females and it will increase the repertoire of data about the host-parasite molecular interplay and its relation with the endocrine system.Repositório Científico do Instituto Politécnico do PortoOliveira, Katia C.Cardoso, RitaDos Santos, Antonio C.Fernandes, RúbenBotelho, Monica C.2020-12-10T01:30:25Z20192019-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.22/15046engOliveira, K. C., Cardoso, R., Santos, A. C. D., Fernandes, R., & Botelho, M. C. (2019). Imbalance of Steroid Hormones in Hamsters Infected with Schistosoma mansoni. Endocrine, Metabolic & Immune Disorders - Drug Targets, 19(8), 1122–1126.10.2174/1871530319666190529121204info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-01-10T01:49:14Zoai:recipp.ipp.pt:10400.22/15046Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T17:34:49.886726Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Imbalance of Steroid Hormones in Hamsters Infected with Schistosoma mansoni |
title |
Imbalance of Steroid Hormones in Hamsters Infected with Schistosoma mansoni |
spellingShingle |
Imbalance of Steroid Hormones in Hamsters Infected with Schistosoma mansoni Oliveira, Katia C. Steroid hormones Schistosoma mansoni infection Host-parasite interaction Estradiol Testosterone Progesterone Infertility |
title_short |
Imbalance of Steroid Hormones in Hamsters Infected with Schistosoma mansoni |
title_full |
Imbalance of Steroid Hormones in Hamsters Infected with Schistosoma mansoni |
title_fullStr |
Imbalance of Steroid Hormones in Hamsters Infected with Schistosoma mansoni |
title_full_unstemmed |
Imbalance of Steroid Hormones in Hamsters Infected with Schistosoma mansoni |
title_sort |
Imbalance of Steroid Hormones in Hamsters Infected with Schistosoma mansoni |
author |
Oliveira, Katia C. |
author_facet |
Oliveira, Katia C. Cardoso, Rita Dos Santos, Antonio C. Fernandes, Rúben Botelho, Monica C. |
author_role |
author |
author2 |
Cardoso, Rita Dos Santos, Antonio C. Fernandes, Rúben Botelho, Monica C. |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
Repositório Científico do Instituto Politécnico do Porto |
dc.contributor.author.fl_str_mv |
Oliveira, Katia C. Cardoso, Rita Dos Santos, Antonio C. Fernandes, Rúben Botelho, Monica C. |
dc.subject.por.fl_str_mv |
Steroid hormones Schistosoma mansoni infection Host-parasite interaction Estradiol Testosterone Progesterone Infertility |
topic |
Steroid hormones Schistosoma mansoni infection Host-parasite interaction Estradiol Testosterone Progesterone Infertility |
description |
Objective: Schistosomiasis is a debilitating disease that affects 200 million people worldwide. Schistosoma haematobium and Schistosoma mansoni are the major causative agents of this disease. Cancer-association and infertility-association in Schistosoma haematobium infection have already been described and it is known that the parasite produces a catechol-estrogen molecule that induces a hormonal imbalance in the host. Methods: In order to better understand the relation of hormonal imbalance in experimental Schistosoma mansoni infection, we investigated a serum panel of steroid hormones in Schistosoma mansoni infected hamsters. Results: We found a decrease in the serum levels of Estradiol (E2), Testosterone and Progesterone in infected females and an increase of Testosterone and a decrease in Progesterone in infected males in comparison with controls. Conclusion: These results indicate that S. mansoni alters the levels of steroid hormones in infected males and females and it will increase the repertoire of data about the host-parasite molecular interplay and its relation with the endocrine system. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019 2019-01-01T00:00:00Z 2020-12-10T01:30:25Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.22/15046 |
url |
http://hdl.handle.net/10400.22/15046 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Oliveira, K. C., Cardoso, R., Santos, A. C. D., Fernandes, R., & Botelho, M. C. (2019). Imbalance of Steroid Hormones in Hamsters Infected with Schistosoma mansoni. Endocrine, Metabolic & Immune Disorders - Drug Targets, 19(8), 1122–1126. 10.2174/1871530319666190529121204 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
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1799131440622862336 |