Tissue-specific splicing factor gene expression signatures

Detalhes bibliográficos
Autor(a) principal: Grosso, Ana Rita
Data de Publicação: 2008
Outros Autores: Gomes, Anita Q., Barbosa-Morais, Nuno, Caldeira, Sandra, Thorne, Natalie P., Grech, Godfrey, von Lindern, Marieke, Carmo-Fonseca, Maria
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/49680
Resumo: © 2008 The Author(s). This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
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spelling Tissue-specific splicing factor gene expression signatures© 2008 The Author(s). This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.The alternative splicing code that controls and coordinates the transcriptome in complex multicellular organisms remains poorly understood. It has long been argued that regulation of alternative splicing relies on combinatorial interactions between multiple proteins, and that tissue-specific splicing decisions most likely result from differences in the concentration and/or activity of these proteins. However, large-scale data to systematically address this issue have just recently started to become available. Here we show that splicing factor gene expression signatures can be identified that reflect cell type and tissue-specific patterns of alternative splicing. We used a computational approach to analyze microarray-based gene expression profiles of splicing factors from mouse, chimpanzee and human tissues. Our results show that brain and testis, the two tissues with highest levels of alternative splicing events, have the largest number of splicing factor genes that are most highly differentially expressed. We further identified SR protein kinases and small nuclear ribonucleoprotein particle (snRNP) proteins among the splicing factor genes that are most highly differentially expressed in a particular tissue. These results indicate the power of generating signature-based predictions as an initial computational approach into a global view of tissue-specific alternative splicing regulation.This work was supported by grants from Fundação para a Ciência e Tecnologia, Portugal (PTDC/SAU-GMG/69739/2006), and the European Commission (MCRTN Eurythron 005499 and EURASNET, LSHG-CT-2005-518238). A.R.G. is supported by a fellowship from Fundação para a Ciência e Tecnologia (SFRH/BD/22825/2005). Funding to pay the Open Access publication charges for this article was provided by EURASNET.Oxford University PressRepositório da Universidade de LisboaGrosso, Ana RitaGomes, Anita Q.Barbosa-Morais, NunoCaldeira, SandraThorne, Natalie P.Grech, Godfreyvon Lindern, MariekeCarmo-Fonseca, Maria2021-09-29T10:09:27Z20082008-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/49680engNucleic Acids Res. 2008 Sep;36(15):4823-48320305-104810.1093/nar/gkn4631362-4962info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:53:38Zoai:repositorio.ul.pt:10451/49680Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:01:18.528439Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Tissue-specific splicing factor gene expression signatures
title Tissue-specific splicing factor gene expression signatures
spellingShingle Tissue-specific splicing factor gene expression signatures
Grosso, Ana Rita
title_short Tissue-specific splicing factor gene expression signatures
title_full Tissue-specific splicing factor gene expression signatures
title_fullStr Tissue-specific splicing factor gene expression signatures
title_full_unstemmed Tissue-specific splicing factor gene expression signatures
title_sort Tissue-specific splicing factor gene expression signatures
author Grosso, Ana Rita
author_facet Grosso, Ana Rita
Gomes, Anita Q.
Barbosa-Morais, Nuno
Caldeira, Sandra
Thorne, Natalie P.
Grech, Godfrey
von Lindern, Marieke
Carmo-Fonseca, Maria
author_role author
author2 Gomes, Anita Q.
Barbosa-Morais, Nuno
Caldeira, Sandra
Thorne, Natalie P.
Grech, Godfrey
von Lindern, Marieke
Carmo-Fonseca, Maria
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Grosso, Ana Rita
Gomes, Anita Q.
Barbosa-Morais, Nuno
Caldeira, Sandra
Thorne, Natalie P.
Grech, Godfrey
von Lindern, Marieke
Carmo-Fonseca, Maria
description © 2008 The Author(s). This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
publishDate 2008
dc.date.none.fl_str_mv 2008
2008-01-01T00:00:00Z
2021-09-29T10:09:27Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/49680
url http://hdl.handle.net/10451/49680
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Nucleic Acids Res. 2008 Sep;36(15):4823-4832
0305-1048
10.1093/nar/gkn463
1362-4962
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Oxford University Press
publisher.none.fl_str_mv Oxford University Press
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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