DISABILITY IN LEPROSY – A RETROSPECTIVE, DESCRIPTIVE AND ANALYTIC STUDY OF 243 PATIENTS TREATED BEFORE AND AFTER THE INTRODUCTION OF MULTIDRUG THERAPY BY THE WHO
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | https://doi.org/10.29021/spdv.72.3.274 |
Resumo: | Introduction: Disability in leprosy may result from peripheral nerve injury. Prevention of disabilities represents one of the major goals of treatment programs.Objectives: Description and comparison of two groups of leprosy patients treated before (“old” patients) and after (“new” patients) multidrug treatment implementation by the World Health Organization, analyzing its potential impact in disability reduction.Materials and methods: Retrospective, descriptive and analytic study of 243 patients distributed in two groups: 164 “old” patient” and 79 “new” patients. Sex, age at diagnosis, time between the onset of symptoms and diagnosis, clinical forms, bacilloscopy, early neurological symptoms, lenght of treatment and occurrence of reaction phenomena were studied. Disabilities were assessed using the World Health Organization disability grading system at least five years after stopping antileprosy treatment. Statistical analysis was performed using software SPSS.18. Chi-square, Mann-Whitney and Kruskal-Wallis tests were used.Results: Disability was more frequent in “old” patients with statistically significant difference in males, BL clinical form, positive basillocopy and neurological symptoms at the onset, and in patients with reaction phenomena. Severe disabilty grades were also superior in “old” patients. There was no relation between the lenght of treatment and disability.Conclusion: Prevention of disabilities is possible by an early diagnosis and proper treatment with multidrug treatment proposed by the World Health Organization. |
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DISABILITY IN LEPROSY – A RETROSPECTIVE, DESCRIPTIVE AND ANALYTIC STUDY OF 243 PATIENTS TREATED BEFORE AND AFTER THE INTRODUCTION OF MULTIDRUG THERAPY BY THE WHOINCAPACIDADE FUNCIONAL NA DOENÇA DE HANSEN – ESTUDO RETROSPECTIVO, DESCRITIVO, E ANALÍTICO DE 243 DOENTES TRATADOS ANTES E DEPOIS DA TERAPÊUTICA DA OMSDisability evaluationLeprosyMotor activityWorld Health OrganizationLepraActividade motoraAvaliação da incapacidadeOrganização Mundial de SaúdeIntroduction: Disability in leprosy may result from peripheral nerve injury. Prevention of disabilities represents one of the major goals of treatment programs.Objectives: Description and comparison of two groups of leprosy patients treated before (“old” patients) and after (“new” patients) multidrug treatment implementation by the World Health Organization, analyzing its potential impact in disability reduction.Materials and methods: Retrospective, descriptive and analytic study of 243 patients distributed in two groups: 164 “old” patient” and 79 “new” patients. Sex, age at diagnosis, time between the onset of symptoms and diagnosis, clinical forms, bacilloscopy, early neurological symptoms, lenght of treatment and occurrence of reaction phenomena were studied. Disabilities were assessed using the World Health Organization disability grading system at least five years after stopping antileprosy treatment. Statistical analysis was performed using software SPSS.18. Chi-square, Mann-Whitney and Kruskal-Wallis tests were used.Results: Disability was more frequent in “old” patients with statistically significant difference in males, BL clinical form, positive basillocopy and neurological symptoms at the onset, and in patients with reaction phenomena. Severe disabilty grades were also superior in “old” patients. There was no relation between the lenght of treatment and disability.Conclusion: Prevention of disabilities is possible by an early diagnosis and proper treatment with multidrug treatment proposed by the World Health Organization.Introdução: A doença de Hansen pode resultar em incapacidade funcional pelo compromisso do sistema nervoso periférico. A prevenção de incapacidade constitui o objectivo dos actuais programas de tratamento, nomeadamente da terapêutica tripla da Organização Mundial de Saúde.Objectivos: Caracterizar e comparar dois grupos de doentes de Hansen, tratados antes (“antigos”) e depois (“recentes”) da introdução da terapêutica tripla da Organização Mundial de Saúde, analisando o benefício desta na redução de incapacidade. Identificar as características dos doentes mais favorecidos nesta potencial redução e, nos doentes “recentes”, determinar se o prolongamento da duração da terapêutica beneficia a redução de incapacidade.Material e Métodos: Estudo retrospectivo e comparativo de 243 doentes, distribuídos em dois grupos, 164 “antigos” e 79 “recentes”, caracterizados quanto ao sexo, idade à data do diagnóstico, intervalo entre início de sintomas e diagnóstico, forma clínica (Ridley e Jopling), ocorrência de reacção, índice bacteriológico (IB) inicial, presença de sintomas neurológicos iniciais, duração da terapêutica anti-leprótica e presença e grau de incapacidade.Resultados: A comparação da presença de incapacidade nos dois grupos mostrou que esta é mais elevada nos doentes “antigos”, sendo significativamente superior no sexo masculino, forma lepromatosa borderline, ocorrência de reacção, IB inicial positivo e com sintomas neurológicos iniciais. A incapacidade grau 2 é também significativamente superior nos doentes “antigos” . Nos doentes “recentes” não se verificou relação entre a duração da terapêutica da Organização Mundial de Saúde e a presença de incapacidade.Conclusão: A prevenção e redução de incapacidade na doença de Hansen é possível através de um diagnóstico precoce e tratamento adequado com a terapêutica tripla da Organização Mundial de Saúde.Sociedade Portuguesa de Dermatologia e Venereologia2014-10-12T00:00:00Zjournal articleinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://doi.org/10.29021/spdv.72.3.274oai:ojs.revista.spdv.com.pt:article/274Journal of the Portuguese Society of Dermatology and Venereology; Vol 72 No 3 (2014): Julho - Setembro; 325-331Revista da Sociedade Portuguesa de Dermatologia e Venereologia; v. 72 n. 3 (2014): Julho - Setembro; 325-3312182-24092182-2395reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPporhttps://revista.spdv.com.pt/index.php/spdv/article/view/274https://doi.org/10.29021/spdv.72.3.274https://revista.spdv.com.pt/index.php/spdv/article/view/274/269Laureano, AndréVieira, RaquelMedeiros, SandraPacheco, Fernando AssisCardoso, Jorgeinfo:eu-repo/semantics/openAccess2022-10-06T12:34:48Zoai:ojs.revista.spdv.com.pt:article/274Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T16:10:48.829371Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
DISABILITY IN LEPROSY – A RETROSPECTIVE, DESCRIPTIVE AND ANALYTIC STUDY OF 243 PATIENTS TREATED BEFORE AND AFTER THE INTRODUCTION OF MULTIDRUG THERAPY BY THE WHO INCAPACIDADE FUNCIONAL NA DOENÇA DE HANSEN – ESTUDO RETROSPECTIVO, DESCRITIVO, E ANALÍTICO DE 243 DOENTES TRATADOS ANTES E DEPOIS DA TERAPÊUTICA DA OMS |
title |
DISABILITY IN LEPROSY – A RETROSPECTIVE, DESCRIPTIVE AND ANALYTIC STUDY OF 243 PATIENTS TREATED BEFORE AND AFTER THE INTRODUCTION OF MULTIDRUG THERAPY BY THE WHO |
spellingShingle |
DISABILITY IN LEPROSY – A RETROSPECTIVE, DESCRIPTIVE AND ANALYTIC STUDY OF 243 PATIENTS TREATED BEFORE AND AFTER THE INTRODUCTION OF MULTIDRUG THERAPY BY THE WHO Laureano, André Disability evaluation Leprosy Motor activity World Health Organization Lepra Actividade motora Avaliação da incapacidade Organização Mundial de Saúde |
title_short |
DISABILITY IN LEPROSY – A RETROSPECTIVE, DESCRIPTIVE AND ANALYTIC STUDY OF 243 PATIENTS TREATED BEFORE AND AFTER THE INTRODUCTION OF MULTIDRUG THERAPY BY THE WHO |
title_full |
DISABILITY IN LEPROSY – A RETROSPECTIVE, DESCRIPTIVE AND ANALYTIC STUDY OF 243 PATIENTS TREATED BEFORE AND AFTER THE INTRODUCTION OF MULTIDRUG THERAPY BY THE WHO |
title_fullStr |
DISABILITY IN LEPROSY – A RETROSPECTIVE, DESCRIPTIVE AND ANALYTIC STUDY OF 243 PATIENTS TREATED BEFORE AND AFTER THE INTRODUCTION OF MULTIDRUG THERAPY BY THE WHO |
title_full_unstemmed |
DISABILITY IN LEPROSY – A RETROSPECTIVE, DESCRIPTIVE AND ANALYTIC STUDY OF 243 PATIENTS TREATED BEFORE AND AFTER THE INTRODUCTION OF MULTIDRUG THERAPY BY THE WHO |
title_sort |
DISABILITY IN LEPROSY – A RETROSPECTIVE, DESCRIPTIVE AND ANALYTIC STUDY OF 243 PATIENTS TREATED BEFORE AND AFTER THE INTRODUCTION OF MULTIDRUG THERAPY BY THE WHO |
author |
Laureano, André |
author_facet |
Laureano, André Vieira, Raquel Medeiros, Sandra Pacheco, Fernando Assis Cardoso, Jorge |
author_role |
author |
author2 |
Vieira, Raquel Medeiros, Sandra Pacheco, Fernando Assis Cardoso, Jorge |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Laureano, André Vieira, Raquel Medeiros, Sandra Pacheco, Fernando Assis Cardoso, Jorge |
dc.subject.por.fl_str_mv |
Disability evaluation Leprosy Motor activity World Health Organization Lepra Actividade motora Avaliação da incapacidade Organização Mundial de Saúde |
topic |
Disability evaluation Leprosy Motor activity World Health Organization Lepra Actividade motora Avaliação da incapacidade Organização Mundial de Saúde |
description |
Introduction: Disability in leprosy may result from peripheral nerve injury. Prevention of disabilities represents one of the major goals of treatment programs.Objectives: Description and comparison of two groups of leprosy patients treated before (“old” patients) and after (“new” patients) multidrug treatment implementation by the World Health Organization, analyzing its potential impact in disability reduction.Materials and methods: Retrospective, descriptive and analytic study of 243 patients distributed in two groups: 164 “old” patient” and 79 “new” patients. Sex, age at diagnosis, time between the onset of symptoms and diagnosis, clinical forms, bacilloscopy, early neurological symptoms, lenght of treatment and occurrence of reaction phenomena were studied. Disabilities were assessed using the World Health Organization disability grading system at least five years after stopping antileprosy treatment. Statistical analysis was performed using software SPSS.18. Chi-square, Mann-Whitney and Kruskal-Wallis tests were used.Results: Disability was more frequent in “old” patients with statistically significant difference in males, BL clinical form, positive basillocopy and neurological symptoms at the onset, and in patients with reaction phenomena. Severe disabilty grades were also superior in “old” patients. There was no relation between the lenght of treatment and disability.Conclusion: Prevention of disabilities is possible by an early diagnosis and proper treatment with multidrug treatment proposed by the World Health Organization. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014-10-12T00:00:00Z |
dc.type.driver.fl_str_mv |
journal article info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://doi.org/10.29021/spdv.72.3.274 oai:ojs.revista.spdv.com.pt:article/274 |
url |
https://doi.org/10.29021/spdv.72.3.274 |
identifier_str_mv |
oai:ojs.revista.spdv.com.pt:article/274 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://revista.spdv.com.pt/index.php/spdv/article/view/274 https://doi.org/10.29021/spdv.72.3.274 https://revista.spdv.com.pt/index.php/spdv/article/view/274/269 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Sociedade Portuguesa de Dermatologia e Venereologia |
publisher.none.fl_str_mv |
Sociedade Portuguesa de Dermatologia e Venereologia |
dc.source.none.fl_str_mv |
Journal of the Portuguese Society of Dermatology and Venereology; Vol 72 No 3 (2014): Julho - Setembro; 325-331 Revista da Sociedade Portuguesa de Dermatologia e Venereologia; v. 72 n. 3 (2014): Julho - Setembro; 325-331 2182-2409 2182-2395 reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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