Increased risk of hepatitis E virus infection in workers occupationally exposed to sheep

Detalhes bibliográficos
Autor(a) principal: Mesquita, João
Data de Publicação: 2020
Outros Autores: Santos-Ferreira, Nanci, Ferreira, Ana S., Albuquerque, Carlos, Nóbrega, Carmen, Esteves, Fernando, Cruz, Rita, Vala, Helena, Nascimento, Maria S. J.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.19/6939
Resumo: Hepatitis E virus (HEV) is an enteric RNA virus from the family Hepeviridae with five genotypes (genotypes 1–4 and 7) known to infect humans. HEV infection is known to have a zoonotic swine origin in industrialized countries. The role of pigs and wild boars as major reservoirs for human infection is today well-established; however, the list of new animal reservoirs is ever-expanding as new HEV strains are continuously being found in a broad host range. The recent detection of HEV in sheep stools brings concerns on the possibility of HEV transmission from these animals to humans, particularly in those occupationally exposed. The present work investigated the potential occupational risk of HEV infection in shepherds and sheep milk cheesemakers—workers occupationally exposed to ovine (WOEOs; N = 96)—from a region of the Centre of Portugal (‘Serra da Estrela’) based on the differences of anti-HEV IgG seroprevalence rates between these professionals and the general population (N = 192). The presence of HEV-specific antibodies in sheep (N = 90) from the same region was also evaluated. The HEV seroprevalence in WOEOs (29.3%) was found to be significantly higher (p = .0198) when compared with population controls (16.1%) which suggests an increased risk for HEV infection in these workers. HEV-specific antibodies were also found in 16.6% of the studied sheep showing that HEV circulates in these animals. Further studies are needed to confirm the zoonotic potential of sheep HEV.
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spelling Increased risk of hepatitis E virus infection in workers occupationally exposed to sheephepatitis E virusoccupational exposureovinesheepzoonosesHepatitis E virus (HEV) is an enteric RNA virus from the family Hepeviridae with five genotypes (genotypes 1–4 and 7) known to infect humans. HEV infection is known to have a zoonotic swine origin in industrialized countries. The role of pigs and wild boars as major reservoirs for human infection is today well-established; however, the list of new animal reservoirs is ever-expanding as new HEV strains are continuously being found in a broad host range. The recent detection of HEV in sheep stools brings concerns on the possibility of HEV transmission from these animals to humans, particularly in those occupationally exposed. The present work investigated the potential occupational risk of HEV infection in shepherds and sheep milk cheesemakers—workers occupationally exposed to ovine (WOEOs; N = 96)—from a region of the Centre of Portugal (‘Serra da Estrela’) based on the differences of anti-HEV IgG seroprevalence rates between these professionals and the general population (N = 192). The presence of HEV-specific antibodies in sheep (N = 90) from the same region was also evaluated. The HEV seroprevalence in WOEOs (29.3%) was found to be significantly higher (p = .0198) when compared with population controls (16.1%) which suggests an increased risk for HEV infection in these workers. HEV-specific antibodies were also found in 16.6% of the studied sheep showing that HEV circulates in these animals. Further studies are needed to confirm the zoonotic potential of sheep HEV.Repositório Científico do Instituto Politécnico de ViseuMesquita, JoãoSantos-Ferreira, NanciFerreira, Ana S.Albuquerque, CarlosNóbrega, CarmenEsteves, FernandoCruz, RitaVala, HelenaNascimento, Maria S. J.2021-12-17T14:28:43Z2020-03-042021-12-12T18:04:09Z2020-03-04T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.19/6939engMesquita, J. R., Santos-Ferreira, N., Ferreira, A. S., Albuquerque, C., Nóbrega, C., Esteves, F., Cruz, R., Vala, H., & Nascimento, M. S. J. (2020). Increased risk of hepatitis E virus infection in workers occupationally exposed to sheep. Transboundary and Emerging Diseases, 67(5), 1918–1921. https://doi.org/10.1111/tbed.135241865-1674cv-prod-173449010.1111/tbed.13524info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-01-16T15:29:05Zoai:repositorio.ipv.pt:10400.19/6939Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T16:44:45.467660Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Increased risk of hepatitis E virus infection in workers occupationally exposed to sheep
title Increased risk of hepatitis E virus infection in workers occupationally exposed to sheep
spellingShingle Increased risk of hepatitis E virus infection in workers occupationally exposed to sheep
Mesquita, João
hepatitis E virus
occupational exposure
ovine
sheep
zoonoses
title_short Increased risk of hepatitis E virus infection in workers occupationally exposed to sheep
title_full Increased risk of hepatitis E virus infection in workers occupationally exposed to sheep
title_fullStr Increased risk of hepatitis E virus infection in workers occupationally exposed to sheep
title_full_unstemmed Increased risk of hepatitis E virus infection in workers occupationally exposed to sheep
title_sort Increased risk of hepatitis E virus infection in workers occupationally exposed to sheep
author Mesquita, João
author_facet Mesquita, João
Santos-Ferreira, Nanci
Ferreira, Ana S.
Albuquerque, Carlos
Nóbrega, Carmen
Esteves, Fernando
Cruz, Rita
Vala, Helena
Nascimento, Maria S. J.
author_role author
author2 Santos-Ferreira, Nanci
Ferreira, Ana S.
Albuquerque, Carlos
Nóbrega, Carmen
Esteves, Fernando
Cruz, Rita
Vala, Helena
Nascimento, Maria S. J.
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório Científico do Instituto Politécnico de Viseu
dc.contributor.author.fl_str_mv Mesquita, João
Santos-Ferreira, Nanci
Ferreira, Ana S.
Albuquerque, Carlos
Nóbrega, Carmen
Esteves, Fernando
Cruz, Rita
Vala, Helena
Nascimento, Maria S. J.
dc.subject.por.fl_str_mv hepatitis E virus
occupational exposure
ovine
sheep
zoonoses
topic hepatitis E virus
occupational exposure
ovine
sheep
zoonoses
description Hepatitis E virus (HEV) is an enteric RNA virus from the family Hepeviridae with five genotypes (genotypes 1–4 and 7) known to infect humans. HEV infection is known to have a zoonotic swine origin in industrialized countries. The role of pigs and wild boars as major reservoirs for human infection is today well-established; however, the list of new animal reservoirs is ever-expanding as new HEV strains are continuously being found in a broad host range. The recent detection of HEV in sheep stools brings concerns on the possibility of HEV transmission from these animals to humans, particularly in those occupationally exposed. The present work investigated the potential occupational risk of HEV infection in shepherds and sheep milk cheesemakers—workers occupationally exposed to ovine (WOEOs; N = 96)—from a region of the Centre of Portugal (‘Serra da Estrela’) based on the differences of anti-HEV IgG seroprevalence rates between these professionals and the general population (N = 192). The presence of HEV-specific antibodies in sheep (N = 90) from the same region was also evaluated. The HEV seroprevalence in WOEOs (29.3%) was found to be significantly higher (p = .0198) when compared with population controls (16.1%) which suggests an increased risk for HEV infection in these workers. HEV-specific antibodies were also found in 16.6% of the studied sheep showing that HEV circulates in these animals. Further studies are needed to confirm the zoonotic potential of sheep HEV.
publishDate 2020
dc.date.none.fl_str_mv 2020-03-04
2020-03-04T00:00:00Z
2021-12-17T14:28:43Z
2021-12-12T18:04:09Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.19/6939
url http://hdl.handle.net/10400.19/6939
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Mesquita, J. R., Santos-Ferreira, N., Ferreira, A. S., Albuquerque, C., Nóbrega, C., Esteves, F., Cruz, R., Vala, H., & Nascimento, M. S. J. (2020). Increased risk of hepatitis E virus infection in workers occupationally exposed to sheep. Transboundary and Emerging Diseases, 67(5), 1918–1921. https://doi.org/10.1111/tbed.13524
1865-1674
cv-prod-1734490
10.1111/tbed.13524
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
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repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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