Increased risk of hepatitis E virus infection in workers occupationally exposed to sheep
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.19/6939 |
Resumo: | Hepatitis E virus (HEV) is an enteric RNA virus from the family Hepeviridae with five genotypes (genotypes 1–4 and 7) known to infect humans. HEV infection is known to have a zoonotic swine origin in industrialized countries. The role of pigs and wild boars as major reservoirs for human infection is today well-established; however, the list of new animal reservoirs is ever-expanding as new HEV strains are continuously being found in a broad host range. The recent detection of HEV in sheep stools brings concerns on the possibility of HEV transmission from these animals to humans, particularly in those occupationally exposed. The present work investigated the potential occupational risk of HEV infection in shepherds and sheep milk cheesemakers—workers occupationally exposed to ovine (WOEOs; N = 96)—from a region of the Centre of Portugal (‘Serra da Estrela’) based on the differences of anti-HEV IgG seroprevalence rates between these professionals and the general population (N = 192). The presence of HEV-specific antibodies in sheep (N = 90) from the same region was also evaluated. The HEV seroprevalence in WOEOs (29.3%) was found to be significantly higher (p = .0198) when compared with population controls (16.1%) which suggests an increased risk for HEV infection in these workers. HEV-specific antibodies were also found in 16.6% of the studied sheep showing that HEV circulates in these animals. Further studies are needed to confirm the zoonotic potential of sheep HEV. |
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Increased risk of hepatitis E virus infection in workers occupationally exposed to sheephepatitis E virusoccupational exposureovinesheepzoonosesHepatitis E virus (HEV) is an enteric RNA virus from the family Hepeviridae with five genotypes (genotypes 1–4 and 7) known to infect humans. HEV infection is known to have a zoonotic swine origin in industrialized countries. The role of pigs and wild boars as major reservoirs for human infection is today well-established; however, the list of new animal reservoirs is ever-expanding as new HEV strains are continuously being found in a broad host range. The recent detection of HEV in sheep stools brings concerns on the possibility of HEV transmission from these animals to humans, particularly in those occupationally exposed. The present work investigated the potential occupational risk of HEV infection in shepherds and sheep milk cheesemakers—workers occupationally exposed to ovine (WOEOs; N = 96)—from a region of the Centre of Portugal (‘Serra da Estrela’) based on the differences of anti-HEV IgG seroprevalence rates between these professionals and the general population (N = 192). The presence of HEV-specific antibodies in sheep (N = 90) from the same region was also evaluated. The HEV seroprevalence in WOEOs (29.3%) was found to be significantly higher (p = .0198) when compared with population controls (16.1%) which suggests an increased risk for HEV infection in these workers. HEV-specific antibodies were also found in 16.6% of the studied sheep showing that HEV circulates in these animals. Further studies are needed to confirm the zoonotic potential of sheep HEV.Repositório Científico do Instituto Politécnico de ViseuMesquita, JoãoSantos-Ferreira, NanciFerreira, Ana S.Albuquerque, CarlosNóbrega, CarmenEsteves, FernandoCruz, RitaVala, HelenaNascimento, Maria S. J.2021-12-17T14:28:43Z2020-03-042021-12-12T18:04:09Z2020-03-04T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.19/6939engMesquita, J. R., Santos-Ferreira, N., Ferreira, A. S., Albuquerque, C., Nóbrega, C., Esteves, F., Cruz, R., Vala, H., & Nascimento, M. S. J. (2020). Increased risk of hepatitis E virus infection in workers occupationally exposed to sheep. Transboundary and Emerging Diseases, 67(5), 1918–1921. https://doi.org/10.1111/tbed.135241865-1674cv-prod-173449010.1111/tbed.13524info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-01-16T15:29:05Zoai:repositorio.ipv.pt:10400.19/6939Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T16:44:45.467660Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Increased risk of hepatitis E virus infection in workers occupationally exposed to sheep |
title |
Increased risk of hepatitis E virus infection in workers occupationally exposed to sheep |
spellingShingle |
Increased risk of hepatitis E virus infection in workers occupationally exposed to sheep Mesquita, João hepatitis E virus occupational exposure ovine sheep zoonoses |
title_short |
Increased risk of hepatitis E virus infection in workers occupationally exposed to sheep |
title_full |
Increased risk of hepatitis E virus infection in workers occupationally exposed to sheep |
title_fullStr |
Increased risk of hepatitis E virus infection in workers occupationally exposed to sheep |
title_full_unstemmed |
Increased risk of hepatitis E virus infection in workers occupationally exposed to sheep |
title_sort |
Increased risk of hepatitis E virus infection in workers occupationally exposed to sheep |
author |
Mesquita, João |
author_facet |
Mesquita, João Santos-Ferreira, Nanci Ferreira, Ana S. Albuquerque, Carlos Nóbrega, Carmen Esteves, Fernando Cruz, Rita Vala, Helena Nascimento, Maria S. J. |
author_role |
author |
author2 |
Santos-Ferreira, Nanci Ferreira, Ana S. Albuquerque, Carlos Nóbrega, Carmen Esteves, Fernando Cruz, Rita Vala, Helena Nascimento, Maria S. J. |
author2_role |
author author author author author author author author |
dc.contributor.none.fl_str_mv |
Repositório Científico do Instituto Politécnico de Viseu |
dc.contributor.author.fl_str_mv |
Mesquita, João Santos-Ferreira, Nanci Ferreira, Ana S. Albuquerque, Carlos Nóbrega, Carmen Esteves, Fernando Cruz, Rita Vala, Helena Nascimento, Maria S. J. |
dc.subject.por.fl_str_mv |
hepatitis E virus occupational exposure ovine sheep zoonoses |
topic |
hepatitis E virus occupational exposure ovine sheep zoonoses |
description |
Hepatitis E virus (HEV) is an enteric RNA virus from the family Hepeviridae with five genotypes (genotypes 1–4 and 7) known to infect humans. HEV infection is known to have a zoonotic swine origin in industrialized countries. The role of pigs and wild boars as major reservoirs for human infection is today well-established; however, the list of new animal reservoirs is ever-expanding as new HEV strains are continuously being found in a broad host range. The recent detection of HEV in sheep stools brings concerns on the possibility of HEV transmission from these animals to humans, particularly in those occupationally exposed. The present work investigated the potential occupational risk of HEV infection in shepherds and sheep milk cheesemakers—workers occupationally exposed to ovine (WOEOs; N = 96)—from a region of the Centre of Portugal (‘Serra da Estrela’) based on the differences of anti-HEV IgG seroprevalence rates between these professionals and the general population (N = 192). The presence of HEV-specific antibodies in sheep (N = 90) from the same region was also evaluated. The HEV seroprevalence in WOEOs (29.3%) was found to be significantly higher (p = .0198) when compared with population controls (16.1%) which suggests an increased risk for HEV infection in these workers. HEV-specific antibodies were also found in 16.6% of the studied sheep showing that HEV circulates in these animals. Further studies are needed to confirm the zoonotic potential of sheep HEV. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-03-04 2020-03-04T00:00:00Z 2021-12-17T14:28:43Z 2021-12-12T18:04:09Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.19/6939 |
url |
http://hdl.handle.net/10400.19/6939 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Mesquita, J. R., Santos-Ferreira, N., Ferreira, A. S., Albuquerque, C., Nóbrega, C., Esteves, F., Cruz, R., Vala, H., & Nascimento, M. S. J. (2020). Increased risk of hepatitis E virus infection in workers occupationally exposed to sheep. Transboundary and Emerging Diseases, 67(5), 1918–1921. https://doi.org/10.1111/tbed.13524 1865-1674 cv-prod-1734490 10.1111/tbed.13524 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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