Potential for adaptation overrides cost of resistance

Detalhes bibliográficos
Autor(a) principal: Moura de Sousa, Jorge
Data de Publicação: 2015
Outros Autores: Sousa, Ana, Bourgard, Catarina, Gordo, Isabel
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.7/870
Resumo: The deposited article is a post-print version and has been submitted to peer review.
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spelling Potential for adaptation overrides cost of resistanceantibiotic resistanceclonal interferenceepistasisevolvabilityexperimental evolutionThe deposited article is a post-print version and has been submitted to peer review.This deposit is composed by the main article plus the supplementary materials of the publication.This work is licensed under the Creative Commons Attribution-NonCommercial 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/To investigate the cost of antibiotic resistance versus the potential for resistant clones to adapt in maintaining polymorphism for resistance. Materials & methods: Experimental evolution of Escherichia coli carrying different resistance alleles was performed under an environment devoid of antibiotics and evolutionary parameters estimated from their frequencies along time. Results & conclusion: Costly resistance mutations were found to coexist with lower cost resistances for hundreds of generations, contrary to the hypothesis that the cost of a resistance dictates its extinction. Estimated evolutionary parameters for the different resistance backgrounds suggest a higher adaptive potential of clones with costly antibiotic resistance mutations, overriding their initial cost of resistance and allowing their maintenance in the absence of drugs.The research leading to these results has received funding from the European Research Council under the European Community's Seventh Framework Programme (FP7/2007–2013)/ERC grant agreement no 260421 – ECOADAPT, and PTDC/BIA-EVF/114622/2009, financed by Fundação para a Ciência e Tecnologia (FCT). I Gordo acknowledges the salary support of LAO/ITQB & FCT. JM de Sousa acknowledges the scholarship SFRH/BD/89151/2012, from FCT.Future MedicineARCAMoura de Sousa, JorgeSousa, AnaBourgard, CatarinaGordo, Isabel2018-05-18T11:33:32Z2015-092015-09-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfapplication/pdfhttp://hdl.handle.net/10400.7/870engPotential for adaptation overrides cost of resistance Jorge Moura de Sousa, Ana Sousa, Catarina Bourgard, and Isabel Gordo Future Microbiology 2015 10:9, 1415-143110.2217/fmb.15.61info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-11-29T14:35:16Zoai:arca.igc.gulbenkian.pt:10400.7/870Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T16:12:04.974525Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Potential for adaptation overrides cost of resistance
title Potential for adaptation overrides cost of resistance
spellingShingle Potential for adaptation overrides cost of resistance
Moura de Sousa, Jorge
antibiotic resistance
clonal interference
epistasis
evolvability
experimental evolution
title_short Potential for adaptation overrides cost of resistance
title_full Potential for adaptation overrides cost of resistance
title_fullStr Potential for adaptation overrides cost of resistance
title_full_unstemmed Potential for adaptation overrides cost of resistance
title_sort Potential for adaptation overrides cost of resistance
author Moura de Sousa, Jorge
author_facet Moura de Sousa, Jorge
Sousa, Ana
Bourgard, Catarina
Gordo, Isabel
author_role author
author2 Sousa, Ana
Bourgard, Catarina
Gordo, Isabel
author2_role author
author
author
dc.contributor.none.fl_str_mv ARCA
dc.contributor.author.fl_str_mv Moura de Sousa, Jorge
Sousa, Ana
Bourgard, Catarina
Gordo, Isabel
dc.subject.por.fl_str_mv antibiotic resistance
clonal interference
epistasis
evolvability
experimental evolution
topic antibiotic resistance
clonal interference
epistasis
evolvability
experimental evolution
description The deposited article is a post-print version and has been submitted to peer review.
publishDate 2015
dc.date.none.fl_str_mv 2015-09
2015-09-01T00:00:00Z
2018-05-18T11:33:32Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.7/870
url http://hdl.handle.net/10400.7/870
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Potential for adaptation overrides cost of resistance Jorge Moura de Sousa, Ana Sousa, Catarina Bourgard, and Isabel Gordo Future Microbiology 2015 10:9, 1415-1431
10.2217/fmb.15.61
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Future Medicine
publisher.none.fl_str_mv Future Medicine
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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