Zika virus dynamics : effects of inoculum dose, the innate immune response and viral interference

Detalhes bibliográficos
Autor(a) principal: Best, Katharine
Data de Publicação: 2021
Outros Autores: Barouch, Dan H., Guedj, Jeremie, Ribeiro, Ruy, Perelson, Alan S.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/45908
Resumo: Copyright: This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication.
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spelling Zika virus dynamics : effects of inoculum dose, the innate immune response and viral interferenceCopyright: This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication.Experimental Zika virus infection in non-human primates results in acute viral load dynamics that can be well-described by mathematical models. The inoculum dose that would be received in a natural infection setting is likely lower than the experimental infections and how this difference affects the viral dynamics and immune response is unclear. Here we study a dataset of experimental infection of non-human primates with a range of doses of Zika virus. We develop new models of infection incorporating both an innate immune response and viral interference with that response. We find that such a model explains the data better than models with no interaction between virus and the immune response. We also find that larger inoculum doses lead to faster dynamics of infection, but approximately the same total amount of viral production.PLOSRepositório da Universidade de LisboaBest, KatharineBarouch, Dan H.Guedj, JeremieRibeiro, RuyPerelson, Alan S.2021-01-22T18:49:12Z20212021-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/45908engPLoS Comput Biol 17(1): e1008564.1553-734X10.1371/journal.pcbi.10085641553-7358info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:47:57Zoai:repositorio.ul.pt:10451/45908Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:58:14.877505Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Zika virus dynamics : effects of inoculum dose, the innate immune response and viral interference
title Zika virus dynamics : effects of inoculum dose, the innate immune response and viral interference
spellingShingle Zika virus dynamics : effects of inoculum dose, the innate immune response and viral interference
Best, Katharine
title_short Zika virus dynamics : effects of inoculum dose, the innate immune response and viral interference
title_full Zika virus dynamics : effects of inoculum dose, the innate immune response and viral interference
title_fullStr Zika virus dynamics : effects of inoculum dose, the innate immune response and viral interference
title_full_unstemmed Zika virus dynamics : effects of inoculum dose, the innate immune response and viral interference
title_sort Zika virus dynamics : effects of inoculum dose, the innate immune response and viral interference
author Best, Katharine
author_facet Best, Katharine
Barouch, Dan H.
Guedj, Jeremie
Ribeiro, Ruy
Perelson, Alan S.
author_role author
author2 Barouch, Dan H.
Guedj, Jeremie
Ribeiro, Ruy
Perelson, Alan S.
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Best, Katharine
Barouch, Dan H.
Guedj, Jeremie
Ribeiro, Ruy
Perelson, Alan S.
description Copyright: This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication.
publishDate 2021
dc.date.none.fl_str_mv 2021-01-22T18:49:12Z
2021
2021-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/45908
url http://hdl.handle.net/10451/45908
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv PLoS Comput Biol 17(1): e1008564.
1553-734X
10.1371/journal.pcbi.1008564
1553-7358
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv PLOS
publisher.none.fl_str_mv PLOS
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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