A pilot study of botulinum toxin for jerky, position-specific, upper limb action tremor

Detalhes bibliográficos
Autor(a) principal: Saifee, Tabish A.
Data de Publicação: 2016
Outros Autores: Teodoro, Tiago, Erro, Roberto, Edwards, Mark J., Cordivari, Carla
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/50500
Resumo: Copyright: © 2016 Saifee et al. This is an open-access article distributed under the terms of the Creative Commons Attribution–Noncommercial–No Derivatives License, which permits the user to copy, distribute, and transmit the work provided that the original authors and source are credited; that no commercial use is made of the work; and that the work is not altered or transformed.
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spelling A pilot study of botulinum toxin for jerky, position-specific, upper limb action tremorUpper limb tremorAction tremorBotulinum toxinCopyright: © 2016 Saifee et al. This is an open-access article distributed under the terms of the Creative Commons Attribution–Noncommercial–No Derivatives License, which permits the user to copy, distribute, and transmit the work provided that the original authors and source are credited; that no commercial use is made of the work; and that the work is not altered or transformed.Background: We aimed to investigate the efficacy and safety of botulinum toxin (BT) injections for jerky action tremor of the upper limb. Methods: We performed an uncontrolled, prospective study of electromyography (EMG)-guided BT injections for jerky, position-specific, upper limb action tremor. The primary outcome was clinical global impression at 3-6 weeks after baseline. Results: Eight patients with jerky, position-specific action tremor involving the upper limb were consecutively recruited. After a median follow-up of 4.4 weeks (interquartile range [IQR] 3.6-6 weeks), four of them rated themselves as "improved" and two as "much improved." Five of these six subjects reported improvements in specific activities of daily living (bringing liquids to mouth, feeding, shaving, and dressing). Upper limb subscore of the Fahn-Tolosa-Marin Tremor Rating Scale (FTM) significantly decreased from 4.5 (4-6) to 3 (2-5) (p = 0.01). Discussion: This pilot, prospective cohort study suggests that EMG-guided BT injections may improve jerky, position-specific, upper limb action tremor. Placebo-controlled studies evaluating larger samples of patients are warranted to confirm these findings.Tiago Teodoro receives funding from the grant ‘‘SFRH/SINTD/95267/2013’’, awarded by ‘‘Fundação para a Ciêcia e a Tecnologia’’.Ubiquity PressRepositório da Universidade de LisboaSaifee, Tabish A.Teodoro, TiagoErro, RobertoEdwards, Mark J.Cordivari, Carla2021-12-21T15:57:13Z20162016-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/50500engTremor Other Hyperkinet Mov (N Y). 2016 Sep 29;6:40610.5334/tohm.2922160-8288info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:54:43Zoai:repositorio.ul.pt:10451/50500Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:01:56.728776Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv A pilot study of botulinum toxin for jerky, position-specific, upper limb action tremor
title A pilot study of botulinum toxin for jerky, position-specific, upper limb action tremor
spellingShingle A pilot study of botulinum toxin for jerky, position-specific, upper limb action tremor
Saifee, Tabish A.
Upper limb tremor
Action tremor
Botulinum toxin
title_short A pilot study of botulinum toxin for jerky, position-specific, upper limb action tremor
title_full A pilot study of botulinum toxin for jerky, position-specific, upper limb action tremor
title_fullStr A pilot study of botulinum toxin for jerky, position-specific, upper limb action tremor
title_full_unstemmed A pilot study of botulinum toxin for jerky, position-specific, upper limb action tremor
title_sort A pilot study of botulinum toxin for jerky, position-specific, upper limb action tremor
author Saifee, Tabish A.
author_facet Saifee, Tabish A.
Teodoro, Tiago
Erro, Roberto
Edwards, Mark J.
Cordivari, Carla
author_role author
author2 Teodoro, Tiago
Erro, Roberto
Edwards, Mark J.
Cordivari, Carla
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Saifee, Tabish A.
Teodoro, Tiago
Erro, Roberto
Edwards, Mark J.
Cordivari, Carla
dc.subject.por.fl_str_mv Upper limb tremor
Action tremor
Botulinum toxin
topic Upper limb tremor
Action tremor
Botulinum toxin
description Copyright: © 2016 Saifee et al. This is an open-access article distributed under the terms of the Creative Commons Attribution–Noncommercial–No Derivatives License, which permits the user to copy, distribute, and transmit the work provided that the original authors and source are credited; that no commercial use is made of the work; and that the work is not altered or transformed.
publishDate 2016
dc.date.none.fl_str_mv 2016
2016-01-01T00:00:00Z
2021-12-21T15:57:13Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/50500
url http://hdl.handle.net/10451/50500
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Tremor Other Hyperkinet Mov (N Y). 2016 Sep 29;6:406
10.5334/tohm.292
2160-8288
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Ubiquity Press
publisher.none.fl_str_mv Ubiquity Press
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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