The role of sex and sex-related hormones in cognition, mood and well-being in older men and women
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/1822/33255 |
Resumo: | Alterations in hormone levels during aging impact on cognition and mood. Serum concentration levels of testosterone (TT), estradiol (E2), follicle-stimulating hormone (FSH), luteinizing hormone (LH), dehydroepiandrosterone sulfate (DHEAS) and prolactin (PRL) were assessed in 120 community-dwellers (51+ years of age, males and females), in a cross-sectional approach. Performance clusters based on executive functioning (GENEXEC), memory (MEM), mood and well-being were obtained. In males, higher PRL levels associated with worse cognitive performance, lower well-being, and higher scores in depression scales, and lower E2 with poorer cognition and higher depressive mood. DHEAS positively associated with GENEXEC and MEM. Nutritional status significantly associated with PRL (positively) and with DHEAS (negatively). Findings indicate that besides the more exhaustively studied E2 and TT, variations in the levels of sex-related hormones such as PRL, FSH, LH and DHEAS are of interest for the mental health aging profile particularly in men. |
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The role of sex and sex-related hormones in cognition, mood and well-being in older men and womenExecutive functionMemoryQuality of lifeSleepNutritionSocial SciencesScience & TechnologyAlterations in hormone levels during aging impact on cognition and mood. Serum concentration levels of testosterone (TT), estradiol (E2), follicle-stimulating hormone (FSH), luteinizing hormone (LH), dehydroepiandrosterone sulfate (DHEAS) and prolactin (PRL) were assessed in 120 community-dwellers (51+ years of age, males and females), in a cross-sectional approach. Performance clusters based on executive functioning (GENEXEC), memory (MEM), mood and well-being were obtained. In males, higher PRL levels associated with worse cognitive performance, lower well-being, and higher scores in depression scales, and lower E2 with poorer cognition and higher depressive mood. DHEAS positively associated with GENEXEC and MEM. Nutritional status significantly associated with PRL (positively) and with DHEAS (negatively). Findings indicate that besides the more exhaustively studied E2 and TT, variations in the levels of sex-related hormones such as PRL, FSH, LH and DHEAS are of interest for the mental health aging profile particularly in men.The work was funded by the European Commission (FP7): "SwitchBox" project (Contract HEALTH-F2-2010-259772) and co-financed by the Portuguese North Regional Operational Program (ON.2-O Novo Norte) under the National Strategic Reference Framework (QREN), through the European Regional Development Fund (FEDER). NCS is supported by a "SwitchBox" project post-doctoral fellowship, TCC by a Fundacao para a Ciencia e Tecnologia (FCT, Portugal) doctoral fellowship (BD SFRH/BD/90078/2012), PSM and CPN by a "MyHealth" (Contract DoIT-13853) doctoral and research fellowship, respectively.Elsevier Science BVUniversidade do MinhoCastanho, Teresa C.Moreira, Pedro Miguel SilvaNunes, Carlos PortugalNovais, Ashley CruzCosta, Patrício SoaresPalha, Joana AlmeidaSousa, NunoSantos, Nadine Correia20142014-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/33255eng0301-051110.1016/j.biopsycho.2014.08.01525196100http://www.elsevier.com/info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:01:28Zoai:repositorium.sdum.uminho.pt:1822/33255Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:51:23.322893Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
The role of sex and sex-related hormones in cognition, mood and well-being in older men and women |
title |
The role of sex and sex-related hormones in cognition, mood and well-being in older men and women |
spellingShingle |
The role of sex and sex-related hormones in cognition, mood and well-being in older men and women Castanho, Teresa C. Executive function Memory Quality of life Sleep Nutrition Social Sciences Science & Technology |
title_short |
The role of sex and sex-related hormones in cognition, mood and well-being in older men and women |
title_full |
The role of sex and sex-related hormones in cognition, mood and well-being in older men and women |
title_fullStr |
The role of sex and sex-related hormones in cognition, mood and well-being in older men and women |
title_full_unstemmed |
The role of sex and sex-related hormones in cognition, mood and well-being in older men and women |
title_sort |
The role of sex and sex-related hormones in cognition, mood and well-being in older men and women |
author |
Castanho, Teresa C. |
author_facet |
Castanho, Teresa C. Moreira, Pedro Miguel Silva Nunes, Carlos Portugal Novais, Ashley Cruz Costa, Patrício Soares Palha, Joana Almeida Sousa, Nuno Santos, Nadine Correia |
author_role |
author |
author2 |
Moreira, Pedro Miguel Silva Nunes, Carlos Portugal Novais, Ashley Cruz Costa, Patrício Soares Palha, Joana Almeida Sousa, Nuno Santos, Nadine Correia |
author2_role |
author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade do Minho |
dc.contributor.author.fl_str_mv |
Castanho, Teresa C. Moreira, Pedro Miguel Silva Nunes, Carlos Portugal Novais, Ashley Cruz Costa, Patrício Soares Palha, Joana Almeida Sousa, Nuno Santos, Nadine Correia |
dc.subject.por.fl_str_mv |
Executive function Memory Quality of life Sleep Nutrition Social Sciences Science & Technology |
topic |
Executive function Memory Quality of life Sleep Nutrition Social Sciences Science & Technology |
description |
Alterations in hormone levels during aging impact on cognition and mood. Serum concentration levels of testosterone (TT), estradiol (E2), follicle-stimulating hormone (FSH), luteinizing hormone (LH), dehydroepiandrosterone sulfate (DHEAS) and prolactin (PRL) were assessed in 120 community-dwellers (51+ years of age, males and females), in a cross-sectional approach. Performance clusters based on executive functioning (GENEXEC), memory (MEM), mood and well-being were obtained. In males, higher PRL levels associated with worse cognitive performance, lower well-being, and higher scores in depression scales, and lower E2 with poorer cognition and higher depressive mood. DHEAS positively associated with GENEXEC and MEM. Nutritional status significantly associated with PRL (positively) and with DHEAS (negatively). Findings indicate that besides the more exhaustively studied E2 and TT, variations in the levels of sex-related hormones such as PRL, FSH, LH and DHEAS are of interest for the mental health aging profile particularly in men. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014 2014-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1822/33255 |
url |
http://hdl.handle.net/1822/33255 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
0301-0511 10.1016/j.biopsycho.2014.08.015 25196100 http://www.elsevier.com/ |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier Science BV |
publisher.none.fl_str_mv |
Elsevier Science BV |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
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1799132286320377856 |