A computational analysis in a cohort of Parkinson’s disease patients and clock-modified colorectal cancer cells reveals common expression alterations in clock-regulated genes
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10451/50411 |
Resumo: | © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
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A computational analysis in a cohort of Parkinson’s disease patients and clock-modified colorectal cancer cells reveals common expression alterations in clock-regulated genesParkinson’s diseaseBioinformaticsCircadian rhythmsColorectal cancerCore-clock knockoutsGene expressionHigh-throughput dataSurvival analysis© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).Increasing evidence suggests a role for circadian dysregulation in prompting disease-related phenotypes in mammals. Cancer and neurodegenerative disorders are two aging related diseases reported to be associated with circadian disruption. In this study, we investigated a possible effect of circadian disruption in Parkinson's disease (PD) and colorectal cancer (CRC). We used high-throughput data sets retrieved from whole blood of idiopathic PD (IPD) patients and time course data sets derived from an in vitro model of CRC including the wildtype and three core-clock knockout (KO) cell lines. Several gene expression alterations in IPD patients resembled the expression profiles in the core-clock KO cells. These include expression changes in DBP, GBA, TEF, SNCA, SERPINA1 and TGFB1. Notably, our results pointed to alterations in the core-clock network in IPD patients when compared to healthy controls and revealed variations in the expression profile of PD-associated genes (e.g., HRAS and GBA) upon disruption of the core-clock genes. Our study characterizes changes at the transcriptomic level following circadian clock disruption on common cellular pathways associated with cancer and neurodegeneration (e.g., immune system, energy metabolism and RNA processing), and it points to a significant influence on the overall survival of colon cancer patients for several genes resulting from our analysis (e.g., TUBB6, PAK6, SLC11A1).MDPIRepositório da Universidade de LisboaYalçin, MügeMalhan, DeekshaBasti, AlirezaPeralta, AnaFerreira, Joaquim JRelógio, Angela2021-12-14T15:21:14Z20212021-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/50411engCancers (Basel). 2021 Nov 28;13(23):597810.3390/cancers132359782072-6694info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:54:34Zoai:repositorio.ul.pt:10451/50411Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:01:52.569689Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
A computational analysis in a cohort of Parkinson’s disease patients and clock-modified colorectal cancer cells reveals common expression alterations in clock-regulated genes |
title |
A computational analysis in a cohort of Parkinson’s disease patients and clock-modified colorectal cancer cells reveals common expression alterations in clock-regulated genes |
spellingShingle |
A computational analysis in a cohort of Parkinson’s disease patients and clock-modified colorectal cancer cells reveals common expression alterations in clock-regulated genes Yalçin, Müge Parkinson’s disease Bioinformatics Circadian rhythms Colorectal cancer Core-clock knockouts Gene expression High-throughput data Survival analysis |
title_short |
A computational analysis in a cohort of Parkinson’s disease patients and clock-modified colorectal cancer cells reveals common expression alterations in clock-regulated genes |
title_full |
A computational analysis in a cohort of Parkinson’s disease patients and clock-modified colorectal cancer cells reveals common expression alterations in clock-regulated genes |
title_fullStr |
A computational analysis in a cohort of Parkinson’s disease patients and clock-modified colorectal cancer cells reveals common expression alterations in clock-regulated genes |
title_full_unstemmed |
A computational analysis in a cohort of Parkinson’s disease patients and clock-modified colorectal cancer cells reveals common expression alterations in clock-regulated genes |
title_sort |
A computational analysis in a cohort of Parkinson’s disease patients and clock-modified colorectal cancer cells reveals common expression alterations in clock-regulated genes |
author |
Yalçin, Müge |
author_facet |
Yalçin, Müge Malhan, Deeksha Basti, Alireza Peralta, Ana Ferreira, Joaquim J Relógio, Angela |
author_role |
author |
author2 |
Malhan, Deeksha Basti, Alireza Peralta, Ana Ferreira, Joaquim J Relógio, Angela |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
Repositório da Universidade de Lisboa |
dc.contributor.author.fl_str_mv |
Yalçin, Müge Malhan, Deeksha Basti, Alireza Peralta, Ana Ferreira, Joaquim J Relógio, Angela |
dc.subject.por.fl_str_mv |
Parkinson’s disease Bioinformatics Circadian rhythms Colorectal cancer Core-clock knockouts Gene expression High-throughput data Survival analysis |
topic |
Parkinson’s disease Bioinformatics Circadian rhythms Colorectal cancer Core-clock knockouts Gene expression High-throughput data Survival analysis |
description |
© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-12-14T15:21:14Z 2021 2021-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10451/50411 |
url |
http://hdl.handle.net/10451/50411 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Cancers (Basel). 2021 Nov 28;13(23):5978 10.3390/cancers13235978 2072-6694 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
MDPI |
publisher.none.fl_str_mv |
MDPI |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799134567695646720 |