Evaluation of the hydroalcoholic extract of Clarisia racemosa as an antiparasitic agent

Detalhes bibliográficos
Autor(a) principal: da Cruz Filho, Iranildo José
Data de Publicação: 2023
Outros Autores: Duarte, Denise Maria Figueiredo Araújo, Marques, Diego Santa Clara, da Rocha, João Victor Ritinto, Diniz, Emily Gabriele Marques, Brayner, Fábio André, Alves, Luiz Carlos, de Azevedo Albuquerque, Mônica Camelo Pessoa, de Lima Aires, André, Nogueira, Fátima, de Lima, Maria do Carmo Alves
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/164973
Resumo: Funding Information: The authors thank the Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) for a grant and M.C.A. Lima Fellowship (Process 306865/612020-3); Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES—Finance Code N° 001) and the Fundação de Amparo à Ciência e Tecnologia do Estado de Pernambuco (FACEPE). J.V.R. Rocha and I.J. Cruz Filho would like to thank FACEPE for the Graduate Scholarship (Process PBPG-1832-4.01/22) and Researcher Fixation Scholarships (Process BFP-0038-4.03/21), respectively. In addition, M.C.A. Lima and A.L. Aires would like to thank FACEPE Research Project Aid (Process APQ-0498-4.03/19) and (Process APQ-Emergent 1181-4.03/22), respectively. We would like to thank Mil Madeiras Preciosas, a subsidiary of the Swiss group Precious Woods ( http://preciouswoods.com.br/ ) for supplying the Clarisia racemosa trunks. Thanks to MR4, who provided us with the Plasmodium falciparum MRA-1029 strain provided by Andrew Talman, Robert Sinden that we used in the trials. The work was partially supported by the FCT project reference CIRCNA/BRB/0281/2019_AMAZING and GHTM-UID/Multi/04413/2013. Funding Information: The authors thank the Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) for a grant and M.C.A. Lima Fellowship (Process 306865/612020-3); Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES—Finance Code N° 001) and the Fundação de Amparo à Ciência e Tecnologia do Estado de Pernambuco (FACEPE). J.V.R. Rocha and I.J. Cruz Filho would like to thank FACEPE for the Graduate Scholarship (Process PBPG-1832-4.01/22) and Researcher Fixation Scholarships (Process BFP-0038-4.03/21), respectively. In addition, M.C.A. Lima and A.L. Aires would like to thank FACEPE Research Project Aid (Process APQ-0498-4.03/19) and (Process APQ-Emergent 1181-4.03/22), respectively. We would like to thank Mil Madeiras Preciosas, a subsidiary of the Swiss group Precious Woods (http://preciouswoods.com.br/) for supplying the Clarisia racemosa trunks. Thanks to MR4, who provided us with the Plasmodium falciparum MRA-1029 strain provided by Andrew Talman, Robert Sinden that we used in the trials. The work was partially supported by the FCT project reference CIRCNA/BRB/0281/2019_AMAZING and GHTM-UID/Multi/04413/2013. Publisher Copyright: © 2023, King Abdulaziz City for Science and Technology.
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spelling Evaluation of the hydroalcoholic extract of Clarisia racemosa as an antiparasitic agentan in vitro approachAmazon forestAntiparasitic agentClarisia racemosaNatural productsQR MicrobiologyQD ChemistryRA Public aspects of medicineBiotechnologyEnvironmental Science (miscellaneous)Agricultural and Biological Sciences (miscellaneous)Drug DiscoveryPharmacology, Toxicology and Pharmaceutics(all)ParasitologySDG 3 - Good Health and Well-beingFunding Information: The authors thank the Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) for a grant and M.C.A. Lima Fellowship (Process 306865/612020-3); Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES—Finance Code N° 001) and the Fundação de Amparo à Ciência e Tecnologia do Estado de Pernambuco (FACEPE). J.V.R. Rocha and I.J. Cruz Filho would like to thank FACEPE for the Graduate Scholarship (Process PBPG-1832-4.01/22) and Researcher Fixation Scholarships (Process BFP-0038-4.03/21), respectively. In addition, M.C.A. Lima and A.L. Aires would like to thank FACEPE Research Project Aid (Process APQ-0498-4.03/19) and (Process APQ-Emergent 1181-4.03/22), respectively. We would like to thank Mil Madeiras Preciosas, a subsidiary of the Swiss group Precious Woods ( http://preciouswoods.com.br/ ) for supplying the Clarisia racemosa trunks. Thanks to MR4, who provided us with the Plasmodium falciparum MRA-1029 strain provided by Andrew Talman, Robert Sinden that we used in the trials. The work was partially supported by the FCT project reference CIRCNA/BRB/0281/2019_AMAZING and GHTM-UID/Multi/04413/2013. Funding Information: The authors thank the Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) for a grant and M.C.A. Lima Fellowship (Process 306865/612020-3); Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES—Finance Code N° 001) and the Fundação de Amparo à Ciência e Tecnologia do Estado de Pernambuco (FACEPE). J.V.R. Rocha and I.J. Cruz Filho would like to thank FACEPE for the Graduate Scholarship (Process PBPG-1832-4.01/22) and Researcher Fixation Scholarships (Process BFP-0038-4.03/21), respectively. In addition, M.C.A. Lima and A.L. Aires would like to thank FACEPE Research Project Aid (Process APQ-0498-4.03/19) and (Process APQ-Emergent 1181-4.03/22), respectively. We would like to thank Mil Madeiras Preciosas, a subsidiary of the Swiss group Precious Woods (http://preciouswoods.com.br/) for supplying the Clarisia racemosa trunks. Thanks to MR4, who provided us with the Plasmodium falciparum MRA-1029 strain provided by Andrew Talman, Robert Sinden that we used in the trials. The work was partially supported by the FCT project reference CIRCNA/BRB/0281/2019_AMAZING and GHTM-UID/Multi/04413/2013. Publisher Copyright: © 2023, King Abdulaziz City for Science and Technology.Clarisia racemosa Ruiz & Pav is a neotropical species found in humid forests from southern Mexico to southern Brazil. There are few studies related to the ethnopharmacological use of C. racemosa. Our objective was to evaluate the hydroalcoholic extract of C. racemosa as a potential antiparasitic agent. For this, we performed in vitro assays against strains of Leishmania amazonensis, Trypanosoma cruzi, Plasmodium falciparum, and Schistosoma mansoni. At the same time, immunomodulatory activity tests were carried out. The results demonstrated that the extract was able to stimulate and activate immune cells. In preliminary antiparasitic tests, structural modifications were observed in the promastigote form of L. amazonensis and in adult worms of S. mansoni. The extract was able to inhibit the growth of trypomastigote form of T. cruzi and finally showed low antiparasitic activity against strains of P. falciparum. It is pioneering work and these results demonstrate that C. racemosa extract is a promising alternative and contributes to the arsenal of possible forms of treatment to combat parasites.Global Health and Tropical Medicine (GHTM)Instituto de Higiene e Medicina Tropical (IHMT)Vector borne diseases and pathogens (VBD)RUNda Cruz Filho, Iranildo JoséDuarte, Denise Maria Figueiredo AraújoMarques, Diego Santa Clarada Rocha, João Victor RitintoDiniz, Emily Gabriele MarquesBrayner, Fábio AndréAlves, Luiz Carlosde Azevedo Albuquerque, Mônica Camelo Pessoade Lima Aires, AndréNogueira, Fátimade Lima, Maria do Carmo Alves2024-03-14T23:59:03Z2023-122023-12-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article15application/pdfhttp://hdl.handle.net/10362/164973eng2190-572XPURE: 82971898https://doi.org/10.1007/s13205-023-03799-2info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-18T01:48:41Zoai:run.unl.pt:10362/164973Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T04:02:06.402904Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Evaluation of the hydroalcoholic extract of Clarisia racemosa as an antiparasitic agent
an in vitro approach
title Evaluation of the hydroalcoholic extract of Clarisia racemosa as an antiparasitic agent
spellingShingle Evaluation of the hydroalcoholic extract of Clarisia racemosa as an antiparasitic agent
da Cruz Filho, Iranildo José
Amazon forest
Antiparasitic agent
Clarisia racemosa
Natural products
QR Microbiology
QD Chemistry
RA Public aspects of medicine
Biotechnology
Environmental Science (miscellaneous)
Agricultural and Biological Sciences (miscellaneous)
Drug Discovery
Pharmacology, Toxicology and Pharmaceutics(all)
Parasitology
SDG 3 - Good Health and Well-being
title_short Evaluation of the hydroalcoholic extract of Clarisia racemosa as an antiparasitic agent
title_full Evaluation of the hydroalcoholic extract of Clarisia racemosa as an antiparasitic agent
title_fullStr Evaluation of the hydroalcoholic extract of Clarisia racemosa as an antiparasitic agent
title_full_unstemmed Evaluation of the hydroalcoholic extract of Clarisia racemosa as an antiparasitic agent
title_sort Evaluation of the hydroalcoholic extract of Clarisia racemosa as an antiparasitic agent
author da Cruz Filho, Iranildo José
author_facet da Cruz Filho, Iranildo José
Duarte, Denise Maria Figueiredo Araújo
Marques, Diego Santa Clara
da Rocha, João Victor Ritinto
Diniz, Emily Gabriele Marques
Brayner, Fábio André
Alves, Luiz Carlos
de Azevedo Albuquerque, Mônica Camelo Pessoa
de Lima Aires, André
Nogueira, Fátima
de Lima, Maria do Carmo Alves
author_role author
author2 Duarte, Denise Maria Figueiredo Araújo
Marques, Diego Santa Clara
da Rocha, João Victor Ritinto
Diniz, Emily Gabriele Marques
Brayner, Fábio André
Alves, Luiz Carlos
de Azevedo Albuquerque, Mônica Camelo Pessoa
de Lima Aires, André
Nogueira, Fátima
de Lima, Maria do Carmo Alves
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Global Health and Tropical Medicine (GHTM)
Instituto de Higiene e Medicina Tropical (IHMT)
Vector borne diseases and pathogens (VBD)
RUN
dc.contributor.author.fl_str_mv da Cruz Filho, Iranildo José
Duarte, Denise Maria Figueiredo Araújo
Marques, Diego Santa Clara
da Rocha, João Victor Ritinto
Diniz, Emily Gabriele Marques
Brayner, Fábio André
Alves, Luiz Carlos
de Azevedo Albuquerque, Mônica Camelo Pessoa
de Lima Aires, André
Nogueira, Fátima
de Lima, Maria do Carmo Alves
dc.subject.por.fl_str_mv Amazon forest
Antiparasitic agent
Clarisia racemosa
Natural products
QR Microbiology
QD Chemistry
RA Public aspects of medicine
Biotechnology
Environmental Science (miscellaneous)
Agricultural and Biological Sciences (miscellaneous)
Drug Discovery
Pharmacology, Toxicology and Pharmaceutics(all)
Parasitology
SDG 3 - Good Health and Well-being
topic Amazon forest
Antiparasitic agent
Clarisia racemosa
Natural products
QR Microbiology
QD Chemistry
RA Public aspects of medicine
Biotechnology
Environmental Science (miscellaneous)
Agricultural and Biological Sciences (miscellaneous)
Drug Discovery
Pharmacology, Toxicology and Pharmaceutics(all)
Parasitology
SDG 3 - Good Health and Well-being
description Funding Information: The authors thank the Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) for a grant and M.C.A. Lima Fellowship (Process 306865/612020-3); Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES—Finance Code N° 001) and the Fundação de Amparo à Ciência e Tecnologia do Estado de Pernambuco (FACEPE). J.V.R. Rocha and I.J. Cruz Filho would like to thank FACEPE for the Graduate Scholarship (Process PBPG-1832-4.01/22) and Researcher Fixation Scholarships (Process BFP-0038-4.03/21), respectively. In addition, M.C.A. Lima and A.L. Aires would like to thank FACEPE Research Project Aid (Process APQ-0498-4.03/19) and (Process APQ-Emergent 1181-4.03/22), respectively. We would like to thank Mil Madeiras Preciosas, a subsidiary of the Swiss group Precious Woods ( http://preciouswoods.com.br/ ) for supplying the Clarisia racemosa trunks. Thanks to MR4, who provided us with the Plasmodium falciparum MRA-1029 strain provided by Andrew Talman, Robert Sinden that we used in the trials. The work was partially supported by the FCT project reference CIRCNA/BRB/0281/2019_AMAZING and GHTM-UID/Multi/04413/2013. Funding Information: The authors thank the Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) for a grant and M.C.A. Lima Fellowship (Process 306865/612020-3); Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES—Finance Code N° 001) and the Fundação de Amparo à Ciência e Tecnologia do Estado de Pernambuco (FACEPE). J.V.R. Rocha and I.J. Cruz Filho would like to thank FACEPE for the Graduate Scholarship (Process PBPG-1832-4.01/22) and Researcher Fixation Scholarships (Process BFP-0038-4.03/21), respectively. In addition, M.C.A. Lima and A.L. Aires would like to thank FACEPE Research Project Aid (Process APQ-0498-4.03/19) and (Process APQ-Emergent 1181-4.03/22), respectively. We would like to thank Mil Madeiras Preciosas, a subsidiary of the Swiss group Precious Woods (http://preciouswoods.com.br/) for supplying the Clarisia racemosa trunks. Thanks to MR4, who provided us with the Plasmodium falciparum MRA-1029 strain provided by Andrew Talman, Robert Sinden that we used in the trials. The work was partially supported by the FCT project reference CIRCNA/BRB/0281/2019_AMAZING and GHTM-UID/Multi/04413/2013. Publisher Copyright: © 2023, King Abdulaziz City for Science and Technology.
publishDate 2023
dc.date.none.fl_str_mv 2023-12
2023-12-01T00:00:00Z
2024-03-14T23:59:03Z
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url http://hdl.handle.net/10362/164973
dc.language.iso.fl_str_mv eng
language eng
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PURE: 82971898
https://doi.org/10.1007/s13205-023-03799-2
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