Evaluation of the hydroalcoholic extract of Clarisia racemosa as an antiparasitic agent
Autor(a) principal: | |
---|---|
Data de Publicação: | 2023 |
Outros Autores: | , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10362/164973 |
Resumo: | Funding Information: The authors thank the Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) for a grant and M.C.A. Lima Fellowship (Process 306865/612020-3); Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES—Finance Code N° 001) and the Fundação de Amparo à Ciência e Tecnologia do Estado de Pernambuco (FACEPE). J.V.R. Rocha and I.J. Cruz Filho would like to thank FACEPE for the Graduate Scholarship (Process PBPG-1832-4.01/22) and Researcher Fixation Scholarships (Process BFP-0038-4.03/21), respectively. In addition, M.C.A. Lima and A.L. Aires would like to thank FACEPE Research Project Aid (Process APQ-0498-4.03/19) and (Process APQ-Emergent 1181-4.03/22), respectively. We would like to thank Mil Madeiras Preciosas, a subsidiary of the Swiss group Precious Woods ( http://preciouswoods.com.br/ ) for supplying the Clarisia racemosa trunks. Thanks to MR4, who provided us with the Plasmodium falciparum MRA-1029 strain provided by Andrew Talman, Robert Sinden that we used in the trials. The work was partially supported by the FCT project reference CIRCNA/BRB/0281/2019_AMAZING and GHTM-UID/Multi/04413/2013. Funding Information: The authors thank the Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) for a grant and M.C.A. Lima Fellowship (Process 306865/612020-3); Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES—Finance Code N° 001) and the Fundação de Amparo à Ciência e Tecnologia do Estado de Pernambuco (FACEPE). J.V.R. Rocha and I.J. Cruz Filho would like to thank FACEPE for the Graduate Scholarship (Process PBPG-1832-4.01/22) and Researcher Fixation Scholarships (Process BFP-0038-4.03/21), respectively. In addition, M.C.A. Lima and A.L. Aires would like to thank FACEPE Research Project Aid (Process APQ-0498-4.03/19) and (Process APQ-Emergent 1181-4.03/22), respectively. We would like to thank Mil Madeiras Preciosas, a subsidiary of the Swiss group Precious Woods (http://preciouswoods.com.br/) for supplying the Clarisia racemosa trunks. Thanks to MR4, who provided us with the Plasmodium falciparum MRA-1029 strain provided by Andrew Talman, Robert Sinden that we used in the trials. The work was partially supported by the FCT project reference CIRCNA/BRB/0281/2019_AMAZING and GHTM-UID/Multi/04413/2013. Publisher Copyright: © 2023, King Abdulaziz City for Science and Technology. |
id |
RCAP_e23a2e85f5e52c0fd802d02fd019ad6c |
---|---|
oai_identifier_str |
oai:run.unl.pt:10362/164973 |
network_acronym_str |
RCAP |
network_name_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository_id_str |
7160 |
spelling |
Evaluation of the hydroalcoholic extract of Clarisia racemosa as an antiparasitic agentan in vitro approachAmazon forestAntiparasitic agentClarisia racemosaNatural productsQR MicrobiologyQD ChemistryRA Public aspects of medicineBiotechnologyEnvironmental Science (miscellaneous)Agricultural and Biological Sciences (miscellaneous)Drug DiscoveryPharmacology, Toxicology and Pharmaceutics(all)ParasitologySDG 3 - Good Health and Well-beingFunding Information: The authors thank the Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) for a grant and M.C.A. Lima Fellowship (Process 306865/612020-3); Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES—Finance Code N° 001) and the Fundação de Amparo à Ciência e Tecnologia do Estado de Pernambuco (FACEPE). J.V.R. Rocha and I.J. Cruz Filho would like to thank FACEPE for the Graduate Scholarship (Process PBPG-1832-4.01/22) and Researcher Fixation Scholarships (Process BFP-0038-4.03/21), respectively. In addition, M.C.A. Lima and A.L. Aires would like to thank FACEPE Research Project Aid (Process APQ-0498-4.03/19) and (Process APQ-Emergent 1181-4.03/22), respectively. We would like to thank Mil Madeiras Preciosas, a subsidiary of the Swiss group Precious Woods ( http://preciouswoods.com.br/ ) for supplying the Clarisia racemosa trunks. Thanks to MR4, who provided us with the Plasmodium falciparum MRA-1029 strain provided by Andrew Talman, Robert Sinden that we used in the trials. The work was partially supported by the FCT project reference CIRCNA/BRB/0281/2019_AMAZING and GHTM-UID/Multi/04413/2013. Funding Information: The authors thank the Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) for a grant and M.C.A. Lima Fellowship (Process 306865/612020-3); Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES—Finance Code N° 001) and the Fundação de Amparo à Ciência e Tecnologia do Estado de Pernambuco (FACEPE). J.V.R. Rocha and I.J. Cruz Filho would like to thank FACEPE for the Graduate Scholarship (Process PBPG-1832-4.01/22) and Researcher Fixation Scholarships (Process BFP-0038-4.03/21), respectively. In addition, M.C.A. Lima and A.L. Aires would like to thank FACEPE Research Project Aid (Process APQ-0498-4.03/19) and (Process APQ-Emergent 1181-4.03/22), respectively. We would like to thank Mil Madeiras Preciosas, a subsidiary of the Swiss group Precious Woods (http://preciouswoods.com.br/) for supplying the Clarisia racemosa trunks. Thanks to MR4, who provided us with the Plasmodium falciparum MRA-1029 strain provided by Andrew Talman, Robert Sinden that we used in the trials. The work was partially supported by the FCT project reference CIRCNA/BRB/0281/2019_AMAZING and GHTM-UID/Multi/04413/2013. Publisher Copyright: © 2023, King Abdulaziz City for Science and Technology.Clarisia racemosa Ruiz & Pav is a neotropical species found in humid forests from southern Mexico to southern Brazil. There are few studies related to the ethnopharmacological use of C. racemosa. Our objective was to evaluate the hydroalcoholic extract of C. racemosa as a potential antiparasitic agent. For this, we performed in vitro assays against strains of Leishmania amazonensis, Trypanosoma cruzi, Plasmodium falciparum, and Schistosoma mansoni. At the same time, immunomodulatory activity tests were carried out. The results demonstrated that the extract was able to stimulate and activate immune cells. In preliminary antiparasitic tests, structural modifications were observed in the promastigote form of L. amazonensis and in adult worms of S. mansoni. The extract was able to inhibit the growth of trypomastigote form of T. cruzi and finally showed low antiparasitic activity against strains of P. falciparum. It is pioneering work and these results demonstrate that C. racemosa extract is a promising alternative and contributes to the arsenal of possible forms of treatment to combat parasites.Global Health and Tropical Medicine (GHTM)Instituto de Higiene e Medicina Tropical (IHMT)Vector borne diseases and pathogens (VBD)RUNda Cruz Filho, Iranildo JoséDuarte, Denise Maria Figueiredo AraújoMarques, Diego Santa Clarada Rocha, João Victor RitintoDiniz, Emily Gabriele MarquesBrayner, Fábio AndréAlves, Luiz Carlosde Azevedo Albuquerque, Mônica Camelo Pessoade Lima Aires, AndréNogueira, Fátimade Lima, Maria do Carmo Alves2024-03-14T23:59:03Z2023-122023-12-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article15application/pdfhttp://hdl.handle.net/10362/164973eng2190-572XPURE: 82971898https://doi.org/10.1007/s13205-023-03799-2info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-18T01:48:41Zoai:run.unl.pt:10362/164973Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T04:02:06.402904Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Evaluation of the hydroalcoholic extract of Clarisia racemosa as an antiparasitic agent an in vitro approach |
title |
Evaluation of the hydroalcoholic extract of Clarisia racemosa as an antiparasitic agent |
spellingShingle |
Evaluation of the hydroalcoholic extract of Clarisia racemosa as an antiparasitic agent da Cruz Filho, Iranildo José Amazon forest Antiparasitic agent Clarisia racemosa Natural products QR Microbiology QD Chemistry RA Public aspects of medicine Biotechnology Environmental Science (miscellaneous) Agricultural and Biological Sciences (miscellaneous) Drug Discovery Pharmacology, Toxicology and Pharmaceutics(all) Parasitology SDG 3 - Good Health and Well-being |
title_short |
Evaluation of the hydroalcoholic extract of Clarisia racemosa as an antiparasitic agent |
title_full |
Evaluation of the hydroalcoholic extract of Clarisia racemosa as an antiparasitic agent |
title_fullStr |
Evaluation of the hydroalcoholic extract of Clarisia racemosa as an antiparasitic agent |
title_full_unstemmed |
Evaluation of the hydroalcoholic extract of Clarisia racemosa as an antiparasitic agent |
title_sort |
Evaluation of the hydroalcoholic extract of Clarisia racemosa as an antiparasitic agent |
author |
da Cruz Filho, Iranildo José |
author_facet |
da Cruz Filho, Iranildo José Duarte, Denise Maria Figueiredo Araújo Marques, Diego Santa Clara da Rocha, João Victor Ritinto Diniz, Emily Gabriele Marques Brayner, Fábio André Alves, Luiz Carlos de Azevedo Albuquerque, Mônica Camelo Pessoa de Lima Aires, André Nogueira, Fátima de Lima, Maria do Carmo Alves |
author_role |
author |
author2 |
Duarte, Denise Maria Figueiredo Araújo Marques, Diego Santa Clara da Rocha, João Victor Ritinto Diniz, Emily Gabriele Marques Brayner, Fábio André Alves, Luiz Carlos de Azevedo Albuquerque, Mônica Camelo Pessoa de Lima Aires, André Nogueira, Fátima de Lima, Maria do Carmo Alves |
author2_role |
author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Global Health and Tropical Medicine (GHTM) Instituto de Higiene e Medicina Tropical (IHMT) Vector borne diseases and pathogens (VBD) RUN |
dc.contributor.author.fl_str_mv |
da Cruz Filho, Iranildo José Duarte, Denise Maria Figueiredo Araújo Marques, Diego Santa Clara da Rocha, João Victor Ritinto Diniz, Emily Gabriele Marques Brayner, Fábio André Alves, Luiz Carlos de Azevedo Albuquerque, Mônica Camelo Pessoa de Lima Aires, André Nogueira, Fátima de Lima, Maria do Carmo Alves |
dc.subject.por.fl_str_mv |
Amazon forest Antiparasitic agent Clarisia racemosa Natural products QR Microbiology QD Chemistry RA Public aspects of medicine Biotechnology Environmental Science (miscellaneous) Agricultural and Biological Sciences (miscellaneous) Drug Discovery Pharmacology, Toxicology and Pharmaceutics(all) Parasitology SDG 3 - Good Health and Well-being |
topic |
Amazon forest Antiparasitic agent Clarisia racemosa Natural products QR Microbiology QD Chemistry RA Public aspects of medicine Biotechnology Environmental Science (miscellaneous) Agricultural and Biological Sciences (miscellaneous) Drug Discovery Pharmacology, Toxicology and Pharmaceutics(all) Parasitology SDG 3 - Good Health and Well-being |
description |
Funding Information: The authors thank the Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) for a grant and M.C.A. Lima Fellowship (Process 306865/612020-3); Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES—Finance Code N° 001) and the Fundação de Amparo à Ciência e Tecnologia do Estado de Pernambuco (FACEPE). J.V.R. Rocha and I.J. Cruz Filho would like to thank FACEPE for the Graduate Scholarship (Process PBPG-1832-4.01/22) and Researcher Fixation Scholarships (Process BFP-0038-4.03/21), respectively. In addition, M.C.A. Lima and A.L. Aires would like to thank FACEPE Research Project Aid (Process APQ-0498-4.03/19) and (Process APQ-Emergent 1181-4.03/22), respectively. We would like to thank Mil Madeiras Preciosas, a subsidiary of the Swiss group Precious Woods ( http://preciouswoods.com.br/ ) for supplying the Clarisia racemosa trunks. Thanks to MR4, who provided us with the Plasmodium falciparum MRA-1029 strain provided by Andrew Talman, Robert Sinden that we used in the trials. The work was partially supported by the FCT project reference CIRCNA/BRB/0281/2019_AMAZING and GHTM-UID/Multi/04413/2013. Funding Information: The authors thank the Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) for a grant and M.C.A. Lima Fellowship (Process 306865/612020-3); Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES—Finance Code N° 001) and the Fundação de Amparo à Ciência e Tecnologia do Estado de Pernambuco (FACEPE). J.V.R. Rocha and I.J. Cruz Filho would like to thank FACEPE for the Graduate Scholarship (Process PBPG-1832-4.01/22) and Researcher Fixation Scholarships (Process BFP-0038-4.03/21), respectively. In addition, M.C.A. Lima and A.L. Aires would like to thank FACEPE Research Project Aid (Process APQ-0498-4.03/19) and (Process APQ-Emergent 1181-4.03/22), respectively. We would like to thank Mil Madeiras Preciosas, a subsidiary of the Swiss group Precious Woods (http://preciouswoods.com.br/) for supplying the Clarisia racemosa trunks. Thanks to MR4, who provided us with the Plasmodium falciparum MRA-1029 strain provided by Andrew Talman, Robert Sinden that we used in the trials. The work was partially supported by the FCT project reference CIRCNA/BRB/0281/2019_AMAZING and GHTM-UID/Multi/04413/2013. Publisher Copyright: © 2023, King Abdulaziz City for Science and Technology. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-12 2023-12-01T00:00:00Z 2024-03-14T23:59:03Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10362/164973 |
url |
http://hdl.handle.net/10362/164973 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
2190-572X PURE: 82971898 https://doi.org/10.1007/s13205-023-03799-2 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
15 application/pdf |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
|
_version_ |
1799138193361076224 |