SARCOPENIA IN GASTRIC CANCER AND BODY COMPOSITION CHANGES AFTER GASTRECTOMY
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | https://doi.org/10.34635/rpc.883 |
Resumo: | Sarcopenia is the phenomenon of loss of muscle strength, muscle performance and muscle mass due to either age (primary sarcopenia) or other illnesses such as cancer (secondary sarcopenia). Sarcopenia has often been defined in the literature as low muscle mass. Sarcopenia among gastric cancer patients has been shown to carry a higher risk of post-operative complications and a higher overall and disease-specific mortality. Our study included 86 patients who underwent surgery for gastric cancer at our institution. Muscle mass was assessed by CT scan (L3 Muscle Index). A subgroup analysis was then performed of 39 patients who had had CT scans 12 months postoperatively. We collected demographic, clinical and body composition data. Sarcopenia was defined by the L3 Muscle Mass Index according to cut-off values previously defined in the literature. We found a prevalence of sarcopenia of 40.7% among gastric cancer patients undergoing gastrectomy. Sarcopenia was associated with a higher overall mortality. Nutritional risk and percentage of body weight lost did not identify sarcopenic patients. 51.4% of sarcopenic patients were overweight, 2.9% were obese. At 12 months post-operatively, 82.1% of patients lost weight and BMI and 76.9% of patients lost muscle mass (lower L3 muscle index) after gastrectomy. We did not find a significant association between the change in muscle mass, BMI or weight. We found that total gastrectomy was significantly associated to muscle mass loss compared to subtotal gastrectomy. We also found a significant association between advanced gastric cancer stage and muscle mass loss. We concluded that while sarcopenia is highly prevalent among gastric cancer patients after gastrectomy, the vast majority of patients lose weight and muscle mass. Since most patients will not improve muscle mass postoperatively it is crucial to implement prehabilitation strategies early on. |
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SARCOPENIA IN GASTRIC CANCER AND BODY COMPOSITION CHANGES AFTER GASTRECTOMYSARCOPÉNIA NO CANCRO GÁSTRICO E MODIFICAÇÕES DA COMPOSIÇÃO CORPORAL PÓS-GASTRECTOMIASarcopenia is the phenomenon of loss of muscle strength, muscle performance and muscle mass due to either age (primary sarcopenia) or other illnesses such as cancer (secondary sarcopenia). Sarcopenia has often been defined in the literature as low muscle mass. Sarcopenia among gastric cancer patients has been shown to carry a higher risk of post-operative complications and a higher overall and disease-specific mortality. Our study included 86 patients who underwent surgery for gastric cancer at our institution. Muscle mass was assessed by CT scan (L3 Muscle Index). A subgroup analysis was then performed of 39 patients who had had CT scans 12 months postoperatively. We collected demographic, clinical and body composition data. Sarcopenia was defined by the L3 Muscle Mass Index according to cut-off values previously defined in the literature. We found a prevalence of sarcopenia of 40.7% among gastric cancer patients undergoing gastrectomy. Sarcopenia was associated with a higher overall mortality. Nutritional risk and percentage of body weight lost did not identify sarcopenic patients. 51.4% of sarcopenic patients were overweight, 2.9% were obese. At 12 months post-operatively, 82.1% of patients lost weight and BMI and 76.9% of patients lost muscle mass (lower L3 muscle index) after gastrectomy. We did not find a significant association between the change in muscle mass, BMI or weight. We found that total gastrectomy was significantly associated to muscle mass loss compared to subtotal gastrectomy. We also found a significant association between advanced gastric cancer stage and muscle mass loss. We concluded that while sarcopenia is highly prevalent among gastric cancer patients after gastrectomy, the vast majority of patients lose weight and muscle mass. Since most patients will not improve muscle mass postoperatively it is crucial to implement prehabilitation strategies early on.A Sarcopénia é o fenómeno da perda de força, performance e massa muscular. Pode ser primário (relacionado com a idade) ou secundário (por exemplo a neoplasia) e tem sido definida na literatura como massa muscular baixa. A Sarcopénia nos doentes com cancro gástrico acarreta um aumento do risco de complicações pós-operatórias e da mortalidade específica e global. O nosso estudo incluiu 86 doentes submetidos a gastrectomia por cancro gástrico, cuja massa muscular foi avaliada por TC (Índice L3). Realizou-se uma subanálise de 39 doentes que tinham realizado TC também aos 12 meses pós-operatórios. Foram analisados dados demográficos, clínicos e de composição corporal. A Sarcopénia foi definida pelo Índice de Massa Muscular em L3, de acordo com valores previamente definidos na literartura. Verificámos uma prevalência de Sarcopénia de 40.7% em doentes submetidos a gastrectomia. A Sarcopénia relacionou-se com uma mortalidade global mais elevada. O Risco Nutricional e a percentagem de peso perdido não identificaram os doentes sarcopénicos. 51.4% dos doentes sarcopénicos tinham excesso de peso, 2.9% eram obesos. Aos 12 meses após gastrectomia, 82.1% dos doentes tinham diminuído de peso e IMC e 79.6% dos doentes tinham perdido massa muscular. Não encontrámos uma associação significativa entre a modificação na massa muscular e no peso ou IMC. Verificámos que a gastrectomia total se associava a uma perda de massa muscular significativamente superior à da gastrectomia subtotal. Verificámos que estadio avançado da neoplasia gástrica se associava a uma maior perda de massa muscular. Concluímos que a prevalência de Sarcopénia em doentes com cancro gástrico é elevada e que, após gastrectomia, a maior parte desses doentes perde peso e massa muscular. Dado que a maioria dos doentes não irão aumentar a sua massa muscular no pós-operatório, é crucial implementar estratégias de pré-habilitação precocemente.Sociedade Portuguesa de Cirurgia2022-02-02info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://doi.org/10.34635/rpc.883https://doi.org/10.34635/rpc.883Revista Portuguesa de Cirurgia; No 51 (2021): Number 51 - October 2021; 23-34Revista Portuguesa de Cirurgia; No 51 (2021): Number 51 - October 2021; 23-342183-11651646-6918reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPenghttps://revista.spcir.com/index.php/spcir/article/view/883https://revista.spcir.com/index.php/spcir/article/view/883/616Ferreira, MargaridaBarreira, Ana LúciaSardinha, FranciscoCosta, JoãoRodrigues, JéssicaGonçalves, AfonsoMatos Costa, Pauloinfo:eu-repo/semantics/openAccess2024-02-22T22:32:43Zoai:revista.spcir.com:article/883Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:10:53.973855Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
SARCOPENIA IN GASTRIC CANCER AND BODY COMPOSITION CHANGES AFTER GASTRECTOMY SARCOPÉNIA NO CANCRO GÁSTRICO E MODIFICAÇÕES DA COMPOSIÇÃO CORPORAL PÓS-GASTRECTOMIA |
title |
SARCOPENIA IN GASTRIC CANCER AND BODY COMPOSITION CHANGES AFTER GASTRECTOMY |
spellingShingle |
SARCOPENIA IN GASTRIC CANCER AND BODY COMPOSITION CHANGES AFTER GASTRECTOMY Ferreira, Margarida |
title_short |
SARCOPENIA IN GASTRIC CANCER AND BODY COMPOSITION CHANGES AFTER GASTRECTOMY |
title_full |
SARCOPENIA IN GASTRIC CANCER AND BODY COMPOSITION CHANGES AFTER GASTRECTOMY |
title_fullStr |
SARCOPENIA IN GASTRIC CANCER AND BODY COMPOSITION CHANGES AFTER GASTRECTOMY |
title_full_unstemmed |
SARCOPENIA IN GASTRIC CANCER AND BODY COMPOSITION CHANGES AFTER GASTRECTOMY |
title_sort |
SARCOPENIA IN GASTRIC CANCER AND BODY COMPOSITION CHANGES AFTER GASTRECTOMY |
author |
Ferreira, Margarida |
author_facet |
Ferreira, Margarida Barreira, Ana Lúcia Sardinha, Francisco Costa, João Rodrigues, Jéssica Gonçalves, Afonso Matos Costa, Paulo |
author_role |
author |
author2 |
Barreira, Ana Lúcia Sardinha, Francisco Costa, João Rodrigues, Jéssica Gonçalves, Afonso Matos Costa, Paulo |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Ferreira, Margarida Barreira, Ana Lúcia Sardinha, Francisco Costa, João Rodrigues, Jéssica Gonçalves, Afonso Matos Costa, Paulo |
description |
Sarcopenia is the phenomenon of loss of muscle strength, muscle performance and muscle mass due to either age (primary sarcopenia) or other illnesses such as cancer (secondary sarcopenia). Sarcopenia has often been defined in the literature as low muscle mass. Sarcopenia among gastric cancer patients has been shown to carry a higher risk of post-operative complications and a higher overall and disease-specific mortality. Our study included 86 patients who underwent surgery for gastric cancer at our institution. Muscle mass was assessed by CT scan (L3 Muscle Index). A subgroup analysis was then performed of 39 patients who had had CT scans 12 months postoperatively. We collected demographic, clinical and body composition data. Sarcopenia was defined by the L3 Muscle Mass Index according to cut-off values previously defined in the literature. We found a prevalence of sarcopenia of 40.7% among gastric cancer patients undergoing gastrectomy. Sarcopenia was associated with a higher overall mortality. Nutritional risk and percentage of body weight lost did not identify sarcopenic patients. 51.4% of sarcopenic patients were overweight, 2.9% were obese. At 12 months post-operatively, 82.1% of patients lost weight and BMI and 76.9% of patients lost muscle mass (lower L3 muscle index) after gastrectomy. We did not find a significant association between the change in muscle mass, BMI or weight. We found that total gastrectomy was significantly associated to muscle mass loss compared to subtotal gastrectomy. We also found a significant association between advanced gastric cancer stage and muscle mass loss. We concluded that while sarcopenia is highly prevalent among gastric cancer patients after gastrectomy, the vast majority of patients lose weight and muscle mass. Since most patients will not improve muscle mass postoperatively it is crucial to implement prehabilitation strategies early on. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-02-02 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://doi.org/10.34635/rpc.883 https://doi.org/10.34635/rpc.883 |
url |
https://doi.org/10.34635/rpc.883 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://revista.spcir.com/index.php/spcir/article/view/883 https://revista.spcir.com/index.php/spcir/article/view/883/616 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
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application/pdf |
dc.publisher.none.fl_str_mv |
Sociedade Portuguesa de Cirurgia |
publisher.none.fl_str_mv |
Sociedade Portuguesa de Cirurgia |
dc.source.none.fl_str_mv |
Revista Portuguesa de Cirurgia; No 51 (2021): Number 51 - October 2021; 23-34 Revista Portuguesa de Cirurgia; No 51 (2021): Number 51 - October 2021; 23-34 2183-1165 1646-6918 reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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