Differential expression of adhesion molecules in sickle cell anemia and gut microbiome effect

Detalhes bibliográficos
Autor(a) principal: Delgadinho, Mariana
Data de Publicação: 2024
Outros Autores: Veiga, Luisa, Ginete, Catarina, Santos, Brígida, Miranda, Armandina, Vasconcelos, Jocelyne Neto de, Brito, Miguel
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.21/16827
Resumo: IPL/2020/SCDVOCbiom_ESTeSL/IPL. UI/BD/150705/2020/FCT.
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spelling Differential expression of adhesion molecules in sickle cell anemia and gut microbiome effectSickle cell anemiaAdhesion moleculesBiomarkersHydroxyureaMicrobiomeIPL/2020/SCDVOCbiom_ESTeSL/IPLUI/BD/150705/2020/FCTIPL/2020/SCDVOCbiom_ESTeSL/IPL. UI/BD/150705/2020/FCT.Sickle cell anemia (SCA) causes a long-standing vascular inflammation state, leading to endothelial dysfunction and chronic overexpression of several adhesion molecules, which contributes to acute and constant vaso-occlusive (VOC) episodes. It has been demonstrated that hydroxyurea (HU) can reduce VOC events, organ damage, blood transfusions, and even the adhesion properties to endothelial cells of SCA subjects. Due to VOC episodes, these patients are also more susceptible to recurrent bacterial translocation and dysbiosis. Given this, our study aimed to uncover the interplay between adhesion molecules, gut microbiome, and hydroxyurea in a population of Angolan SCA children. Serum and fecal samples were obtained before and after HU treatment in 35 children. After HU, four of these adhesion molecules were significantly reduced: sE-selectin (p = 0.002), ADAMTS13 (p = 0.023), sICAM-1 (p = 0.003), and sVCAM-1 (p = 0.018). A positive correlation was observed between the number of neutrophils and sICAM-1, platelets, and sP-selectin, and also between leukocytes, sICAM-1, and sVCAM-1. Most taxa showing a significant correlation mainly belonged to the Clostridiales order. Specifically, from the Clostridium genera, the groups g19, g21, and g34 were all negatively correlated with HbF levels; g19, g21, and g24 positively correlated with leukocytes; g19 positively with neutrophils and sVCAM-1; and g34 positively with E- and P-selectin. Serratia, an opportunistic pathogen, was positively correlated with sE-selectin and sICAM-1 levels. Additionally, a negative correlation was observed between sP-selectin and Bifidobacterium. Research studies in this area could improve our understanding and contribute to finding new prognostic biomarkers to guarantee precise SCA patient stratification and predict severe complications.SpringerRCIPLDelgadinho, MarianaVeiga, LuisaGinete, CatarinaSantos, BrígidaMiranda, ArmandinaVasconcelos, Jocelyne Neto deBrito, Miguel2024-01-09T15:58:09Z2024-022024-02-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.21/16827engDelgadinho M, Veiga L, Ginete C, Santos B, Miranda A, Brito M, et al. Differential expression of adhesion molecules in sickle cell anemia and gut microbiome effect. Ann Hematol. 2024;103(2):409-19.10.1007/s00277-023-05589-5info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-01-31T02:16:04Zoai:repositorio.ipl.pt:10400.21/16827Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T01:31:15.999503Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Differential expression of adhesion molecules in sickle cell anemia and gut microbiome effect
title Differential expression of adhesion molecules in sickle cell anemia and gut microbiome effect
spellingShingle Differential expression of adhesion molecules in sickle cell anemia and gut microbiome effect
Delgadinho, Mariana
Sickle cell anemia
Adhesion molecules
Biomarkers
Hydroxyurea
Microbiome
IPL/2020/SCDVOCbiom_ESTeSL/IPL
UI/BD/150705/2020/FCT
title_short Differential expression of adhesion molecules in sickle cell anemia and gut microbiome effect
title_full Differential expression of adhesion molecules in sickle cell anemia and gut microbiome effect
title_fullStr Differential expression of adhesion molecules in sickle cell anemia and gut microbiome effect
title_full_unstemmed Differential expression of adhesion molecules in sickle cell anemia and gut microbiome effect
title_sort Differential expression of adhesion molecules in sickle cell anemia and gut microbiome effect
author Delgadinho, Mariana
author_facet Delgadinho, Mariana
Veiga, Luisa
Ginete, Catarina
Santos, Brígida
Miranda, Armandina
Vasconcelos, Jocelyne Neto de
Brito, Miguel
author_role author
author2 Veiga, Luisa
Ginete, Catarina
Santos, Brígida
Miranda, Armandina
Vasconcelos, Jocelyne Neto de
Brito, Miguel
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv RCIPL
dc.contributor.author.fl_str_mv Delgadinho, Mariana
Veiga, Luisa
Ginete, Catarina
Santos, Brígida
Miranda, Armandina
Vasconcelos, Jocelyne Neto de
Brito, Miguel
dc.subject.por.fl_str_mv Sickle cell anemia
Adhesion molecules
Biomarkers
Hydroxyurea
Microbiome
IPL/2020/SCDVOCbiom_ESTeSL/IPL
UI/BD/150705/2020/FCT
topic Sickle cell anemia
Adhesion molecules
Biomarkers
Hydroxyurea
Microbiome
IPL/2020/SCDVOCbiom_ESTeSL/IPL
UI/BD/150705/2020/FCT
description IPL/2020/SCDVOCbiom_ESTeSL/IPL. UI/BD/150705/2020/FCT.
publishDate 2024
dc.date.none.fl_str_mv 2024-01-09T15:58:09Z
2024-02
2024-02-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.21/16827
url http://hdl.handle.net/10400.21/16827
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Delgadinho M, Veiga L, Ginete C, Santos B, Miranda A, Brito M, et al. Differential expression of adhesion molecules in sickle cell anemia and gut microbiome effect. Ann Hematol. 2024;103(2):409-19.
10.1007/s00277-023-05589-5
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Springer
publisher.none.fl_str_mv Springer
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
_version_ 1799136794724270080

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