Childhood generalized specific phobia as an early marker of internalizing psychopathology across the lifespan
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | https://doi.org/10.1186/s12916-019-1328-3 |
Resumo: | Background: Specific phobia (SP) is a relatively common disorder associated with high levels of psychiatric comorbidity. Because of its early onset, SP may be a useful early marker of internalizing psychopathology, especially if generalized to multiple situations. This study aimed to evaluate the association of childhood generalized SP with comorbid internalizing disorders. Methods: We conducted retrospective analyses of the cross-sectional population-based World Mental Health Surveys using the Composite International Diagnostic Interview. Outcomes were lifetime prevalence, age of onset, and persistence of internalizing disorders; past-month disability; lifetime suicidality; and 12-month serious mental illness. Logistic and linear regressions were used to assess the association of these outcomes with the number of subtypes of childhood-onset (< 13 years) SP. Results: Among 123,628 respondents from 25 countries, retrospectively reported prevalence of childhood SP was 5.9%, 56% of whom reported one, 25% two, 10% three, and 8% four or more subtypes. Lifetime prevalence of internalizing disorders increased from 18.2% among those without childhood SP to 46.3% among those with one and 75.6% those with 4+ subtypes (OR = 2.4, 95% CI 2.3-2.5, p < 0.001). Twelve-month persistence of lifetime internalizing comorbidity at interview increased from 47.9% among those without childhood SP to 59.0% and 79.1% among those with 1 and 4+ subtypes (OR = 1.4, 95% CI 1.4-1.5, p < 0.001). Respondents with 4+ subtypes also reported significantly more disability (3.5 days out of role in the past month) than those without childhood SP (1.1 days) or with only 1 subtype (1.8 days) (B = 0.56, SE 0.06, p < 0.001) and a much higher rate of lifetime suicide attempts (16.8%) than those without childhood SP (2.0%) or with only 1 subtype (6.5%) (OR = 1.7, 95% CI 1.7-1.8, p < 0.001). Conclusions: This large international study shows that childhood-onset generalized SP is related to adverse outcomes in the internalizing domain throughout the life course. Comorbidity, persistence, and severity of internalizing disorders all increased with the number of childhood SP subtypes. Although our study cannot establish whether SP is causally associated with these poor outcomes or whether other factors, such as a shared underlying vulnerability, explain the association, our findings clearly show that childhood generalized SP identifies an important target group for early intervention. |
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Childhood generalized specific phobia as an early marker of internalizing psychopathology across the lifespanResults from the World Mental Health SurveysComorbidityEarly markersInternalizing disordersSpecific phobiaSuicidalityMedicine(all)SDG 3 - Good Health and Well-beingBackground: Specific phobia (SP) is a relatively common disorder associated with high levels of psychiatric comorbidity. Because of its early onset, SP may be a useful early marker of internalizing psychopathology, especially if generalized to multiple situations. This study aimed to evaluate the association of childhood generalized SP with comorbid internalizing disorders. Methods: We conducted retrospective analyses of the cross-sectional population-based World Mental Health Surveys using the Composite International Diagnostic Interview. Outcomes were lifetime prevalence, age of onset, and persistence of internalizing disorders; past-month disability; lifetime suicidality; and 12-month serious mental illness. Logistic and linear regressions were used to assess the association of these outcomes with the number of subtypes of childhood-onset (< 13 years) SP. Results: Among 123,628 respondents from 25 countries, retrospectively reported prevalence of childhood SP was 5.9%, 56% of whom reported one, 25% two, 10% three, and 8% four or more subtypes. Lifetime prevalence of internalizing disorders increased from 18.2% among those without childhood SP to 46.3% among those with one and 75.6% those with 4+ subtypes (OR = 2.4, 95% CI 2.3-2.5, p < 0.001). Twelve-month persistence of lifetime internalizing comorbidity at interview increased from 47.9% among those without childhood SP to 59.0% and 79.1% among those with 1 and 4+ subtypes (OR = 1.4, 95% CI 1.4-1.5, p < 0.001). Respondents with 4+ subtypes also reported significantly more disability (3.5 days out of role in the past month) than those without childhood SP (1.1 days) or with only 1 subtype (1.8 days) (B = 0.56, SE 0.06, p < 0.001) and a much higher rate of lifetime suicide attempts (16.8%) than those without childhood SP (2.0%) or with only 1 subtype (6.5%) (OR = 1.7, 95% CI 1.7-1.8, p < 0.001). Conclusions: This large international study shows that childhood-onset generalized SP is related to adverse outcomes in the internalizing domain throughout the life course. Comorbidity, persistence, and severity of internalizing disorders all increased with the number of childhood SP subtypes. Although our study cannot establish whether SP is causally associated with these poor outcomes or whether other factors, such as a shared underlying vulnerability, explain the association, our findings clearly show that childhood generalized SP identifies an important target group for early intervention.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)RUNDe Vries, Ymkje AnnaAl-Hamzawi, AliAlonso, JordiBorges, GuilhermeBruffaerts, RonnyBunting, BrendanCaldas-De-Almeida, José MiguelCia, Alfredo H.De Girolamo, GiovanniDinolova, Rumyana V.Esan, OluyomiFlorescu, SilviaGureje, OyeHaro, Josep MariaHu, ChiyiKaram, Elie G.Karam, Aimee NasserKawakami, NoritoKiejna, AndrzejKovess-Masfety, VivianeLee, SingMneimneh, ZeinaNavarro-Mateu, FernandoPiazza, MarinaScott, Kate M.Ten Have, MargreetTorres, YolandaViana, Maria CarmenKessler, Ronald C.De Jonge, PeterAguilar-Gaxiola, SergioAl-Kaisy, Mohammed SalihAndrade, Laura HelenaBenjet, CorinaBromet, Evelyn J.De Almeida, Jose Miguel CaldasCardoso, GraçaChatterji, SomnathDegenhardt, LouisaDemyttenaere, KoenHinkov, HristoHu, Chi YiKaram, Aimee NasserLepine, Jean PierreLevinson, DaphnaMcGrath, JohnMedina-Mora, Maria ElenaMoskalewicz, JacekPennell, Beth EllenPosada-Villa, JoseScott, Kate M.Slade, TimStagnaro, Juan CarlosStein, Dan J.Whiteford, HarveyWilliams, David R.Wojtyniak, Bogdan2019-07-18T22:51:25Z2019-05-242019-05-24T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://doi.org/10.1186/s12916-019-1328-3eng1741-7015PURE: 13814981http://www.scopus.com/inward/record.url?scp=85066396682&partnerID=8YFLogxKhttps://doi.org/10.1186/s12916-019-1328-3info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T04:34:41Zoai:run.unl.pt:10362/75891Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:35:35.238441Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Childhood generalized specific phobia as an early marker of internalizing psychopathology across the lifespan Results from the World Mental Health Surveys |
title |
Childhood generalized specific phobia as an early marker of internalizing psychopathology across the lifespan |
spellingShingle |
Childhood generalized specific phobia as an early marker of internalizing psychopathology across the lifespan De Vries, Ymkje Anna Comorbidity Early markers Internalizing disorders Specific phobia Suicidality Medicine(all) SDG 3 - Good Health and Well-being |
title_short |
Childhood generalized specific phobia as an early marker of internalizing psychopathology across the lifespan |
title_full |
Childhood generalized specific phobia as an early marker of internalizing psychopathology across the lifespan |
title_fullStr |
Childhood generalized specific phobia as an early marker of internalizing psychopathology across the lifespan |
title_full_unstemmed |
Childhood generalized specific phobia as an early marker of internalizing psychopathology across the lifespan |
title_sort |
Childhood generalized specific phobia as an early marker of internalizing psychopathology across the lifespan |
author |
De Vries, Ymkje Anna |
author_facet |
De Vries, Ymkje Anna Al-Hamzawi, Ali Alonso, Jordi Borges, Guilherme Bruffaerts, Ronny Bunting, Brendan Caldas-De-Almeida, José Miguel Cia, Alfredo H. De Girolamo, Giovanni Dinolova, Rumyana V. Esan, Oluyomi Florescu, Silvia Gureje, Oye Haro, Josep Maria Hu, Chiyi Karam, Elie G. Karam, Aimee Nasser Kawakami, Norito Kiejna, Andrzej Kovess-Masfety, Viviane Lee, Sing Mneimneh, Zeina Navarro-Mateu, Fernando Piazza, Marina Scott, Kate M. Ten Have, Margreet Torres, Yolanda Viana, Maria Carmen Kessler, Ronald C. De Jonge, Peter Aguilar-Gaxiola, Sergio Al-Kaisy, Mohammed Salih Andrade, Laura Helena Benjet, Corina Bromet, Evelyn J. De Almeida, Jose Miguel Caldas Cardoso, Graça Chatterji, Somnath Degenhardt, Louisa Demyttenaere, Koen Hinkov, Hristo Hu, Chi Yi Lepine, Jean Pierre Levinson, Daphna McGrath, John Medina-Mora, Maria Elena Moskalewicz, Jacek Pennell, Beth Ellen Posada-Villa, Jose Slade, Tim Stagnaro, Juan Carlos Stein, Dan J. Whiteford, Harvey Williams, David R. Wojtyniak, Bogdan |
author_role |
author |
author2 |
Al-Hamzawi, Ali Alonso, Jordi Borges, Guilherme Bruffaerts, Ronny Bunting, Brendan Caldas-De-Almeida, José Miguel Cia, Alfredo H. De Girolamo, Giovanni Dinolova, Rumyana V. Esan, Oluyomi Florescu, Silvia Gureje, Oye Haro, Josep Maria Hu, Chiyi Karam, Elie G. Karam, Aimee Nasser Kawakami, Norito Kiejna, Andrzej Kovess-Masfety, Viviane Lee, Sing Mneimneh, Zeina Navarro-Mateu, Fernando Piazza, Marina Scott, Kate M. Ten Have, Margreet Torres, Yolanda Viana, Maria Carmen Kessler, Ronald C. De Jonge, Peter Aguilar-Gaxiola, Sergio Al-Kaisy, Mohammed Salih Andrade, Laura Helena Benjet, Corina Bromet, Evelyn J. De Almeida, Jose Miguel Caldas Cardoso, Graça Chatterji, Somnath Degenhardt, Louisa Demyttenaere, Koen Hinkov, Hristo Hu, Chi Yi Lepine, Jean Pierre Levinson, Daphna McGrath, John Medina-Mora, Maria Elena Moskalewicz, Jacek Pennell, Beth Ellen Posada-Villa, Jose Slade, Tim Stagnaro, Juan Carlos Stein, Dan J. Whiteford, Harvey Williams, David R. Wojtyniak, Bogdan |
author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM) RUN |
dc.contributor.author.fl_str_mv |
De Vries, Ymkje Anna Al-Hamzawi, Ali Alonso, Jordi Borges, Guilherme Bruffaerts, Ronny Bunting, Brendan Caldas-De-Almeida, José Miguel Cia, Alfredo H. De Girolamo, Giovanni Dinolova, Rumyana V. Esan, Oluyomi Florescu, Silvia Gureje, Oye Haro, Josep Maria Hu, Chiyi Karam, Elie G. Karam, Aimee Nasser Kawakami, Norito Kiejna, Andrzej Kovess-Masfety, Viviane Lee, Sing Mneimneh, Zeina Navarro-Mateu, Fernando Piazza, Marina Scott, Kate M. Ten Have, Margreet Torres, Yolanda Viana, Maria Carmen Kessler, Ronald C. De Jonge, Peter Aguilar-Gaxiola, Sergio Al-Kaisy, Mohammed Salih Andrade, Laura Helena Benjet, Corina Bromet, Evelyn J. De Almeida, Jose Miguel Caldas Cardoso, Graça Chatterji, Somnath Degenhardt, Louisa Demyttenaere, Koen Hinkov, Hristo Hu, Chi Yi Karam, Aimee Nasser Lepine, Jean Pierre Levinson, Daphna McGrath, John Medina-Mora, Maria Elena Moskalewicz, Jacek Pennell, Beth Ellen Posada-Villa, Jose Scott, Kate M. Slade, Tim Stagnaro, Juan Carlos Stein, Dan J. Whiteford, Harvey Williams, David R. Wojtyniak, Bogdan |
dc.subject.por.fl_str_mv |
Comorbidity Early markers Internalizing disorders Specific phobia Suicidality Medicine(all) SDG 3 - Good Health and Well-being |
topic |
Comorbidity Early markers Internalizing disorders Specific phobia Suicidality Medicine(all) SDG 3 - Good Health and Well-being |
description |
Background: Specific phobia (SP) is a relatively common disorder associated with high levels of psychiatric comorbidity. Because of its early onset, SP may be a useful early marker of internalizing psychopathology, especially if generalized to multiple situations. This study aimed to evaluate the association of childhood generalized SP with comorbid internalizing disorders. Methods: We conducted retrospective analyses of the cross-sectional population-based World Mental Health Surveys using the Composite International Diagnostic Interview. Outcomes were lifetime prevalence, age of onset, and persistence of internalizing disorders; past-month disability; lifetime suicidality; and 12-month serious mental illness. Logistic and linear regressions were used to assess the association of these outcomes with the number of subtypes of childhood-onset (< 13 years) SP. Results: Among 123,628 respondents from 25 countries, retrospectively reported prevalence of childhood SP was 5.9%, 56% of whom reported one, 25% two, 10% three, and 8% four or more subtypes. Lifetime prevalence of internalizing disorders increased from 18.2% among those without childhood SP to 46.3% among those with one and 75.6% those with 4+ subtypes (OR = 2.4, 95% CI 2.3-2.5, p < 0.001). Twelve-month persistence of lifetime internalizing comorbidity at interview increased from 47.9% among those without childhood SP to 59.0% and 79.1% among those with 1 and 4+ subtypes (OR = 1.4, 95% CI 1.4-1.5, p < 0.001). Respondents with 4+ subtypes also reported significantly more disability (3.5 days out of role in the past month) than those without childhood SP (1.1 days) or with only 1 subtype (1.8 days) (B = 0.56, SE 0.06, p < 0.001) and a much higher rate of lifetime suicide attempts (16.8%) than those without childhood SP (2.0%) or with only 1 subtype (6.5%) (OR = 1.7, 95% CI 1.7-1.8, p < 0.001). Conclusions: This large international study shows that childhood-onset generalized SP is related to adverse outcomes in the internalizing domain throughout the life course. Comorbidity, persistence, and severity of internalizing disorders all increased with the number of childhood SP subtypes. Although our study cannot establish whether SP is causally associated with these poor outcomes or whether other factors, such as a shared underlying vulnerability, explain the association, our findings clearly show that childhood generalized SP identifies an important target group for early intervention. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-07-18T22:51:25Z 2019-05-24 2019-05-24T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
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publishedVersion |
dc.identifier.uri.fl_str_mv |
https://doi.org/10.1186/s12916-019-1328-3 |
url |
https://doi.org/10.1186/s12916-019-1328-3 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
1741-7015 PURE: 13814981 http://www.scopus.com/inward/record.url?scp=85066396682&partnerID=8YFLogxK https://doi.org/10.1186/s12916-019-1328-3 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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