Risk Biomarkers for Biochemical Recurrence after Radical Prostatectomy for Prostate Cancer Using Clinical and MRI-Derived Semantic Features

Detalhes bibliográficos
Autor(a) principal: Guerra, Adalgisa
Data de Publicação: 2023
Outros Autores: Alves, Filipe Caseiro, Maes, Kris, Maio, Rui, Villeirs, Geert, Mouriño, Helena
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/160671
Resumo: Funding Information: This work is supported by a PhD student scholarship (A.G.) from the Luz Saúde Clinical Research and Innovation program, Award Number: ID LH.INV.F2019027. This work is also partially financed by national funds through FCT—Fundação para a Ciência e Tecnologia, Portugal, under the project UIDB/00006/2020. Publisher Copyright: © 2023 by the authors.
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spelling Risk Biomarkers for Biochemical Recurrence after Radical Prostatectomy for Prostate Cancer Using Clinical and MRI-Derived Semantic Featuresbiochemical recurrencebiochemical recurrence-free survivalextracapsular extensionmagnetic resonance imagingprostate cancerradical prostatectomystagingOncologyCancer ResearchSDG 3 - Good Health and Well-beingFunding Information: This work is supported by a PhD student scholarship (A.G.) from the Luz Saúde Clinical Research and Innovation program, Award Number: ID LH.INV.F2019027. This work is also partially financed by national funds through FCT—Fundação para a Ciência e Tecnologia, Portugal, under the project UIDB/00006/2020. Publisher Copyright: © 2023 by the authors.Objectives: This study aimed to assess the impact of the covariates derived from a predictive model for detecting extracapsular extension on pathology (pECE+) on biochemical recurrence-free survival (BCRFS) within 4 years after robotic-assisted radical prostatectomy (RARP). Methods: Retrospective data analysis was conducted from a single center between 2015 and 2022. Variables under consideration included prostate-specific antigen (PSA) levels, patient age, prostate volume, MRI semantic features, and Grade Group (GG). We also assessed the influence of pECE+ and positive surgical margins on BCRFS. To attain these goals, we used the Kaplan–Meier survival function and the multivariable Cox regression model. Additionally, we analyzed the MRI features on BCR (biochemical recurrence) in low/intermediate risk patients. Results: A total of 177 participants with a follow-up exceeding 6 months post-RARP were included. The 1-year, 2-year, and 4-year risks of BCR after radical prostatectomy were 5%, 13%, and 21%, respectively. The non-parametric approach for the survival analysis showed that adverse MRI features such as macroscopic ECE on MRI (mECE+), capsular disruption, high tumor capsular contact length (TCCL), GG ≥ 4, positive surgical margins (PSM), and pECE+ on pathology were risk factors for BCR. In low/intermediate-risk patients (pECE− and GG < 4), the presence of adverse MRI features has been shown to increase the risk of BCR. Conclusions: The study highlights the importance of incorporating predictive MRI features for detecting extracapsular extension pre-surgery in influencing early outcomes and clinical decision making; mECE+, TCCL, capsular disruption, and GG ≥ 4 based on pre-surgical biopsy were independent prognostic factors for early BCR. The presence of adverse features on MRI can assist in identifying low/intermediate-risk patients who will benefit from closer monitoring.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)RUNGuerra, AdalgisaAlves, Filipe CaseiroMaes, KrisMaio, RuiVilleirs, GeertMouriño, Helena2023-11-28T22:37:42Z2023-112023-11-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/160671eng2072-6694PURE: 76724580https://doi.org/10.3390/cancers15215296info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:43:25Zoai:run.unl.pt:10362/160671Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:58:10.030432Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Risk Biomarkers for Biochemical Recurrence after Radical Prostatectomy for Prostate Cancer Using Clinical and MRI-Derived Semantic Features
title Risk Biomarkers for Biochemical Recurrence after Radical Prostatectomy for Prostate Cancer Using Clinical and MRI-Derived Semantic Features
spellingShingle Risk Biomarkers for Biochemical Recurrence after Radical Prostatectomy for Prostate Cancer Using Clinical and MRI-Derived Semantic Features
Guerra, Adalgisa
biochemical recurrence
biochemical recurrence-free survival
extracapsular extension
magnetic resonance imaging
prostate cancer
radical prostatectomy
staging
Oncology
Cancer Research
SDG 3 - Good Health and Well-being
title_short Risk Biomarkers for Biochemical Recurrence after Radical Prostatectomy for Prostate Cancer Using Clinical and MRI-Derived Semantic Features
title_full Risk Biomarkers for Biochemical Recurrence after Radical Prostatectomy for Prostate Cancer Using Clinical and MRI-Derived Semantic Features
title_fullStr Risk Biomarkers for Biochemical Recurrence after Radical Prostatectomy for Prostate Cancer Using Clinical and MRI-Derived Semantic Features
title_full_unstemmed Risk Biomarkers for Biochemical Recurrence after Radical Prostatectomy for Prostate Cancer Using Clinical and MRI-Derived Semantic Features
title_sort Risk Biomarkers for Biochemical Recurrence after Radical Prostatectomy for Prostate Cancer Using Clinical and MRI-Derived Semantic Features
author Guerra, Adalgisa
author_facet Guerra, Adalgisa
Alves, Filipe Caseiro
Maes, Kris
Maio, Rui
Villeirs, Geert
Mouriño, Helena
author_role author
author2 Alves, Filipe Caseiro
Maes, Kris
Maio, Rui
Villeirs, Geert
Mouriño, Helena
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
RUN
dc.contributor.author.fl_str_mv Guerra, Adalgisa
Alves, Filipe Caseiro
Maes, Kris
Maio, Rui
Villeirs, Geert
Mouriño, Helena
dc.subject.por.fl_str_mv biochemical recurrence
biochemical recurrence-free survival
extracapsular extension
magnetic resonance imaging
prostate cancer
radical prostatectomy
staging
Oncology
Cancer Research
SDG 3 - Good Health and Well-being
topic biochemical recurrence
biochemical recurrence-free survival
extracapsular extension
magnetic resonance imaging
prostate cancer
radical prostatectomy
staging
Oncology
Cancer Research
SDG 3 - Good Health and Well-being
description Funding Information: This work is supported by a PhD student scholarship (A.G.) from the Luz Saúde Clinical Research and Innovation program, Award Number: ID LH.INV.F2019027. This work is also partially financed by national funds through FCT—Fundação para a Ciência e Tecnologia, Portugal, under the project UIDB/00006/2020. Publisher Copyright: © 2023 by the authors.
publishDate 2023
dc.date.none.fl_str_mv 2023-11-28T22:37:42Z
2023-11
2023-11-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/160671
url http://hdl.handle.net/10362/160671
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 2072-6694
PURE: 76724580
https://doi.org/10.3390/cancers15215296
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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