Influence of the Particle Size on the Electrical, Magnetic and Biological Properties of the Bioglass® Containing Iron Oxide
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2023 |
| Outros Autores: | , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10362/162721 |
Resumo: | This research was funded by FEDER funds through the COMPETE 2020 Program and National Funds through FCT—Portuguese Foundation for Science and Technology under the project LISBOA-01-0247-FEDER-039985/POCI-01-0247-FEDER-039985. S.R.G. and A.S.P. acknowledge FCT—Portuguese Foundation for Science and Technology for the PhD grant UI/DB/151287/2021. Publisher Copyright: © 2023 by the authors. |
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Influence of the Particle Size on the Electrical, Magnetic and Biological Properties of the Bioglass® Containing Iron Oxide45S5 BioglassbioactivitycytotoxicityFeOosteosarcoma treatmentparticle sizeElectronic, Optical and Magnetic MaterialsChemistry (miscellaneous)Materials ChemistryThis research was funded by FEDER funds through the COMPETE 2020 Program and National Funds through FCT—Portuguese Foundation for Science and Technology under the project LISBOA-01-0247-FEDER-039985/POCI-01-0247-FEDER-039985. S.R.G. and A.S.P. acknowledge FCT—Portuguese Foundation for Science and Technology for the PhD grant UI/DB/151287/2021. Publisher Copyright: © 2023 by the authors.Bioglasses have been used throughout the past century as a biomaterial in the bone regeneration field. However, recent studies have attempted to use them as a therapeutic material as well, mainly in the treatment of osteosarcomas. The most widely recognized bioglass is the 45S5 Bioglass, invented by Larry Hench et al., which presents higher bioactivity. A possible application of this bioglass in the treatment of osteosarcomas can be accomplished by adding specific ions, such as iron, that will allow the use of magnetic hyperthermia and Fenton reaction as therapeutic mechanisms. In this study, a 45S5 Bioglass containing 10%mol of Fe2O3 was produced using the melt-quenching method. A group of samples was prepared by changing the overall ball milling time, from 1 h up to 48 h, to analyze the effects of iron in the bioactive glass matrix and evaluate the influence of particle size on their physical and biological properties. The studied bioglasses showed no evidence of changes in the amorphous structural nature compared to the 45S5 Bioglass. The data of the impedance spectroscopy study revealed that the addition of Fe2O3 can increase the standard rate constant of the Electro-Fenton reaction, with the sample milled for 12 h showing the most promising results. The reduction in the particle size influenced the cytotoxicity and the bioactivity. The samples with lower particle sizes showed a higher level of cytotoxicity.CENIMAT-i3N - Centro de Investigação de Materiais (Lab. Associado I3N)DCM - Departamento de Ciência dos MateriaisDF – Departamento de FísicaRUNRegadas, Joana SoaresGavinho, Sílvia RodriguesTeixeira, Sílvia Soretode Jesus, Juliana VieiraPádua, Ana SofiaSilva, Jorge CarvalhoDevesa, SusanaGraça, Manuel Pedro Fernandes2024-01-24T17:08:53Z2023-09-122023-09-12T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article14application/pdfhttp://hdl.handle.net/10362/162721eng2312-7481PURE: 82011062https://doi.org/10.3390/magnetochemistry9090209info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:45:41Zoai:run.unl.pt:10362/162721Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:59:02.804053Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
Influence of the Particle Size on the Electrical, Magnetic and Biological Properties of the Bioglass® Containing Iron Oxide |
| title |
Influence of the Particle Size on the Electrical, Magnetic and Biological Properties of the Bioglass® Containing Iron Oxide |
| spellingShingle |
Influence of the Particle Size on the Electrical, Magnetic and Biological Properties of the Bioglass® Containing Iron Oxide Regadas, Joana Soares 45S5 Bioglass bioactivity cytotoxicity FeO osteosarcoma treatment particle size Electronic, Optical and Magnetic Materials Chemistry (miscellaneous) Materials Chemistry |
| title_short |
Influence of the Particle Size on the Electrical, Magnetic and Biological Properties of the Bioglass® Containing Iron Oxide |
| title_full |
Influence of the Particle Size on the Electrical, Magnetic and Biological Properties of the Bioglass® Containing Iron Oxide |
| title_fullStr |
Influence of the Particle Size on the Electrical, Magnetic and Biological Properties of the Bioglass® Containing Iron Oxide |
| title_full_unstemmed |
Influence of the Particle Size on the Electrical, Magnetic and Biological Properties of the Bioglass® Containing Iron Oxide |
| title_sort |
Influence of the Particle Size on the Electrical, Magnetic and Biological Properties of the Bioglass® Containing Iron Oxide |
| author |
Regadas, Joana Soares |
| author_facet |
Regadas, Joana Soares Gavinho, Sílvia Rodrigues Teixeira, Sílvia Soreto de Jesus, Juliana Vieira Pádua, Ana Sofia Silva, Jorge Carvalho Devesa, Susana Graça, Manuel Pedro Fernandes |
| author_role |
author |
| author2 |
Gavinho, Sílvia Rodrigues Teixeira, Sílvia Soreto de Jesus, Juliana Vieira Pádua, Ana Sofia Silva, Jorge Carvalho Devesa, Susana Graça, Manuel Pedro Fernandes |
| author2_role |
author author author author author author author |
| dc.contributor.none.fl_str_mv |
CENIMAT-i3N - Centro de Investigação de Materiais (Lab. Associado I3N) DCM - Departamento de Ciência dos Materiais DF – Departamento de Física RUN |
| dc.contributor.author.fl_str_mv |
Regadas, Joana Soares Gavinho, Sílvia Rodrigues Teixeira, Sílvia Soreto de Jesus, Juliana Vieira Pádua, Ana Sofia Silva, Jorge Carvalho Devesa, Susana Graça, Manuel Pedro Fernandes |
| dc.subject.por.fl_str_mv |
45S5 Bioglass bioactivity cytotoxicity FeO osteosarcoma treatment particle size Electronic, Optical and Magnetic Materials Chemistry (miscellaneous) Materials Chemistry |
| topic |
45S5 Bioglass bioactivity cytotoxicity FeO osteosarcoma treatment particle size Electronic, Optical and Magnetic Materials Chemistry (miscellaneous) Materials Chemistry |
| description |
This research was funded by FEDER funds through the COMPETE 2020 Program and National Funds through FCT—Portuguese Foundation for Science and Technology under the project LISBOA-01-0247-FEDER-039985/POCI-01-0247-FEDER-039985. S.R.G. and A.S.P. acknowledge FCT—Portuguese Foundation for Science and Technology for the PhD grant UI/DB/151287/2021. Publisher Copyright: © 2023 by the authors. |
| publishDate |
2023 |
| dc.date.none.fl_str_mv |
2023-09-12 2023-09-12T00:00:00Z 2024-01-24T17:08:53Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10362/162721 |
| url |
http://hdl.handle.net/10362/162721 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
2312-7481 PURE: 82011062 https://doi.org/10.3390/magnetochemistry9090209 |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
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openAccess |
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14 application/pdf |
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reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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