Biocompatibility, Bioactivity, and Antibacterial Behaviour of Cerium-Containing Bioglass®
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2022 |
| Outros Autores: | , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10362/150560 |
Resumo: | The authors extend their appreciation to the FEDER funds through the COMPETE 2020 Program and National Funds through FCT—Portuguese Foundation for Science and Technology under the project LISBOA-01-0247-FEDER-039985/POCI-01-0247-FEDER-039985, and Associate Laboratory i4HB (LA/P/0140/2020). Publisher Copyright: © 2022 by the authors. |
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Biocompatibility, Bioactivity, and Antibacterial Behaviour of Cerium-Containing Bioglass®antibacterial propertiesbioactivityBioglassceriumimplant coatingsChemical Engineering(all)Materials Science(all)The authors extend their appreciation to the FEDER funds through the COMPETE 2020 Program and National Funds through FCT—Portuguese Foundation for Science and Technology under the project LISBOA-01-0247-FEDER-039985/POCI-01-0247-FEDER-039985, and Associate Laboratory i4HB (LA/P/0140/2020). Publisher Copyright: © 2022 by the authors.The main reason for the increased use of dental implants in clinical practice is associated with aesthetic parameters. Implants are also presented as the only technique that conserves and stimulates natural bone. However, there are several problems associated with infections, such as peri-implantitis. This disease reveals a progressive inflammatory action that affects the hard and soft tissues surrounding the implant, leading to implant loss. To prevent the onset of this disease, coating the implant with bioactive glasses has been suggested. In addition to its intrinsic function of promoting bone regeneration, it is also possible to insert therapeutic ions, such as cerium. Cerium has several advantages when the aim is to improve osseointegration and prevent infectious problems with dental implant placement. It promotes increased growth and the differentiation of osteoblasts, improves the mechanical properties of bone, and prevents bacterial adhesion and proliferation that may occur on the implant surface. This antibacterial effect is due to its ability to disrupt the cell wall and membrane of bacteria, thus interfering with vital metabolic functions such as respiration. In addition, its antioxidant effect reverses oxidative stress after implantation in bone. In this work, Bioglass 45S5 with CeO2 with different percentages (0.25, 0.5, 1, and 2 mol%) was developed by the melt-quenching method. The materials were analyzed in terms of morphological, structural, and biological (cytotoxicity, bioactivity, and antibacterial activity) properties. The addition of cerium did not promote structural changes to the bioactive glass, which shows no cytotoxicity for the Saos-2 cell line up to 25 mg/mL of extract concentration for all cerium contents. For the maximum cerium concentration (2 mol%) the bioactive glass shows an evident inhibitory effect for Escherichia coli and Streptococcus mutans bacteria. Furthermore, all samples showed the beginning of the deposition of a CaP-rich layer on the surface of the material after 24 h.CENIMAT-i3N - Centro de Investigação de Materiais (Lab. Associado I3N)UCIBIO - Applied Molecular Biosciences UnitDCV - Departamento de Ciências da VidaRUNGavinho, Sílvia R.Pádua, Ana SofiaSá-Nogueira, IsabelSilva, Jorge C.Borges, João P.Costa, Luís C.Graça, Manuel Pedro F.2023-03-14T22:43:26Z2022-12-182022-12-18T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article11application/pdfhttp://hdl.handle.net/10362/150560engGavinho, S. R., Pádua, A. S., Sá-Nogueira, I., Silva, J. C., Borges, J. P., Costa, L. C., & Graça, M. P. F. (2022). Biocompatibility, Bioactivity, and Antibacterial Behaviour of Cerium-Containing Bioglass®. Nanomaterials, 12(24), [4479]. https://doi.org/10.3390/nano122444792079-4991PURE: 55636839https://doi.org/10.3390/nano12244479info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:32:34Zoai:run.unl.pt:10362/150560Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:54:10.951946Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
Biocompatibility, Bioactivity, and Antibacterial Behaviour of Cerium-Containing Bioglass® |
| title |
Biocompatibility, Bioactivity, and Antibacterial Behaviour of Cerium-Containing Bioglass® |
| spellingShingle |
Biocompatibility, Bioactivity, and Antibacterial Behaviour of Cerium-Containing Bioglass® Gavinho, Sílvia R. antibacterial properties bioactivity Bioglass cerium implant coatings Chemical Engineering(all) Materials Science(all) |
| title_short |
Biocompatibility, Bioactivity, and Antibacterial Behaviour of Cerium-Containing Bioglass® |
| title_full |
Biocompatibility, Bioactivity, and Antibacterial Behaviour of Cerium-Containing Bioglass® |
| title_fullStr |
Biocompatibility, Bioactivity, and Antibacterial Behaviour of Cerium-Containing Bioglass® |
| title_full_unstemmed |
Biocompatibility, Bioactivity, and Antibacterial Behaviour of Cerium-Containing Bioglass® |
| title_sort |
Biocompatibility, Bioactivity, and Antibacterial Behaviour of Cerium-Containing Bioglass® |
| author |
Gavinho, Sílvia R. |
| author_facet |
Gavinho, Sílvia R. Pádua, Ana Sofia Sá-Nogueira, Isabel Silva, Jorge C. Borges, João P. Costa, Luís C. Graça, Manuel Pedro F. |
| author_role |
author |
| author2 |
Pádua, Ana Sofia Sá-Nogueira, Isabel Silva, Jorge C. Borges, João P. Costa, Luís C. Graça, Manuel Pedro F. |
| author2_role |
author author author author author author |
| dc.contributor.none.fl_str_mv |
CENIMAT-i3N - Centro de Investigação de Materiais (Lab. Associado I3N) UCIBIO - Applied Molecular Biosciences Unit DCV - Departamento de Ciências da Vida RUN |
| dc.contributor.author.fl_str_mv |
Gavinho, Sílvia R. Pádua, Ana Sofia Sá-Nogueira, Isabel Silva, Jorge C. Borges, João P. Costa, Luís C. Graça, Manuel Pedro F. |
| dc.subject.por.fl_str_mv |
antibacterial properties bioactivity Bioglass cerium implant coatings Chemical Engineering(all) Materials Science(all) |
| topic |
antibacterial properties bioactivity Bioglass cerium implant coatings Chemical Engineering(all) Materials Science(all) |
| description |
The authors extend their appreciation to the FEDER funds through the COMPETE 2020 Program and National Funds through FCT—Portuguese Foundation for Science and Technology under the project LISBOA-01-0247-FEDER-039985/POCI-01-0247-FEDER-039985, and Associate Laboratory i4HB (LA/P/0140/2020). Publisher Copyright: © 2022 by the authors. |
| publishDate |
2022 |
| dc.date.none.fl_str_mv |
2022-12-18 2022-12-18T00:00:00Z 2023-03-14T22:43:26Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10362/150560 |
| url |
http://hdl.handle.net/10362/150560 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
Gavinho, S. R., Pádua, A. S., Sá-Nogueira, I., Silva, J. C., Borges, J. P., Costa, L. C., & Graça, M. P. F. (2022). Biocompatibility, Bioactivity, and Antibacterial Behaviour of Cerium-Containing Bioglass®. Nanomaterials, 12(24), [4479]. https://doi.org/10.3390/nano12244479 2079-4991 PURE: 55636839 https://doi.org/10.3390/nano12244479 |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
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openAccess |
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11 application/pdf |
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reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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