Monkeypox: From A Neglected Tropical Disease to a Public Health Threat
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.18/8531 |
Resumo: | Since the first case of human monkeypox was diagnosed in 1970, the disease remained endemic in several countries in West and Central Africa. In 1996, there was a sudden increase in cases in the Democratic Republic of Congo (DRC), and since 2017 an ongoing outbreak in Nigeria took place, probably related to the population growth, human invasion of MPXV animal habitat reservoirs, and the waning of the cross-protection offered from smallpox immunization, later ending in 1980. Since May 2022, an unprecedented outbreak of human monkeypox has rapidly spread around the world, outside endemic regions of Africa, through new modes of transmission, showing differences in clinical features compared with previous reports. The 2022 MPXV strain belongs to the clade of West Africa but diverges from the original strain, making the virus more transmissible. The authors review the main milestones in more than 50 years of history of human monkeypox, from a rare viral zoonotic infection to a public health emergency. |
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Monkeypox: From A Neglected Tropical Disease to a Public Health ThreatMonkeypoxMonkeypox VirusZoonosisOutbreakEmerging Infectious DiseasesWest AfricaCentral AfricaInfecções Sistémicas e ZoonosesSince the first case of human monkeypox was diagnosed in 1970, the disease remained endemic in several countries in West and Central Africa. In 1996, there was a sudden increase in cases in the Democratic Republic of Congo (DRC), and since 2017 an ongoing outbreak in Nigeria took place, probably related to the population growth, human invasion of MPXV animal habitat reservoirs, and the waning of the cross-protection offered from smallpox immunization, later ending in 1980. Since May 2022, an unprecedented outbreak of human monkeypox has rapidly spread around the world, outside endemic regions of Africa, through new modes of transmission, showing differences in clinical features compared with previous reports. The 2022 MPXV strain belongs to the clade of West Africa but diverges from the original strain, making the virus more transmissible. The authors review the main milestones in more than 50 years of history of human monkeypox, from a rare viral zoonotic infection to a public health emergency.The writing of this manuscript received the support of Fundação para a Ciência e a Tecnologia, grant numbers UIDB/04295/2020 and UIDP/04295/2020.MDPIRepositório Científico do Instituto Nacional de SaúdeAntunes, FranciscoCordeiro, RitaVirgolino, Ana2023-02-28T11:21:47Z2022-09-302022-09-30T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.18/8531engInfect Dis Rep. 2022 Sep 30;14(5):772-783. doi: 10.3390/idr14050079. Review2036-743010.3390/idr14050079info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-20T15:42:37Zoai:repositorio.insa.pt:10400.18/8531Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:43:10.469466Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Monkeypox: From A Neglected Tropical Disease to a Public Health Threat |
title |
Monkeypox: From A Neglected Tropical Disease to a Public Health Threat |
spellingShingle |
Monkeypox: From A Neglected Tropical Disease to a Public Health Threat Antunes, Francisco Monkeypox Monkeypox Virus Zoonosis Outbreak Emerging Infectious Diseases West Africa Central Africa Infecções Sistémicas e Zoonoses |
title_short |
Monkeypox: From A Neglected Tropical Disease to a Public Health Threat |
title_full |
Monkeypox: From A Neglected Tropical Disease to a Public Health Threat |
title_fullStr |
Monkeypox: From A Neglected Tropical Disease to a Public Health Threat |
title_full_unstemmed |
Monkeypox: From A Neglected Tropical Disease to a Public Health Threat |
title_sort |
Monkeypox: From A Neglected Tropical Disease to a Public Health Threat |
author |
Antunes, Francisco |
author_facet |
Antunes, Francisco Cordeiro, Rita Virgolino, Ana |
author_role |
author |
author2 |
Cordeiro, Rita Virgolino, Ana |
author2_role |
author author |
dc.contributor.none.fl_str_mv |
Repositório Científico do Instituto Nacional de Saúde |
dc.contributor.author.fl_str_mv |
Antunes, Francisco Cordeiro, Rita Virgolino, Ana |
dc.subject.por.fl_str_mv |
Monkeypox Monkeypox Virus Zoonosis Outbreak Emerging Infectious Diseases West Africa Central Africa Infecções Sistémicas e Zoonoses |
topic |
Monkeypox Monkeypox Virus Zoonosis Outbreak Emerging Infectious Diseases West Africa Central Africa Infecções Sistémicas e Zoonoses |
description |
Since the first case of human monkeypox was diagnosed in 1970, the disease remained endemic in several countries in West and Central Africa. In 1996, there was a sudden increase in cases in the Democratic Republic of Congo (DRC), and since 2017 an ongoing outbreak in Nigeria took place, probably related to the population growth, human invasion of MPXV animal habitat reservoirs, and the waning of the cross-protection offered from smallpox immunization, later ending in 1980. Since May 2022, an unprecedented outbreak of human monkeypox has rapidly spread around the world, outside endemic regions of Africa, through new modes of transmission, showing differences in clinical features compared with previous reports. The 2022 MPXV strain belongs to the clade of West Africa but diverges from the original strain, making the virus more transmissible. The authors review the main milestones in more than 50 years of history of human monkeypox, from a rare viral zoonotic infection to a public health emergency. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-09-30 2022-09-30T00:00:00Z 2023-02-28T11:21:47Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.18/8531 |
url |
http://hdl.handle.net/10400.18/8531 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Infect Dis Rep. 2022 Sep 30;14(5):772-783. doi: 10.3390/idr14050079. Review 2036-7430 10.3390/idr14050079 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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MDPI |
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MDPI |
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