Hepatitis C pretreatment profile and gender differences : cognition and disease severity effects

Detalhes bibliográficos
Autor(a) principal: Pires Barreira, David
Data de Publicação: 2019
Outros Autores: Marinho, Rui, Bicho, Manuel, Flores, Isabel, Fialho, Renata, Ouakinin, Sílvia
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/40079
Resumo: Copyright © 2019 Barreira, Marinho, Bicho, Flores, Fialho and Ouakinin. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
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spelling Hepatitis C pretreatment profile and gender differences : cognition and disease severity effectsHepatitis CNeurocognitionAnxietyDepressionGenderDisease severityCopyright © 2019 Barreira, Marinho, Bicho, Flores, Fialho and Ouakinin. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.Background: The hepatitis C virus (HCV) is known to infect the brain, however, the findings based on associated neuropsychiatric syndrome are controversial and the association itself remains unclear. Gender research in HCV infection is limited, failing to integrate the role of gender differences in neurocognitive syndrome. The aim of this study was to characterize psychological and neurocognitive profiles in HCV-infected patients before treatment and to explore gender differences in those profiles, as well as the impact of disease severity. Methods: A total of 86 patients diagnosed with chronic hepatitis C were included. Depression and anxiety were assessed using Hamilton anxiety scale (HAM-A), Hamilton depression scale (HAM-D), Beck Depression Inventory (BDI). For cognition, a neuropsychological battery to measure attention, concentration and memory was used, and executive function components validated for the Portuguese population was also used before starting treatment. To identify the disease severity, platelet ratio index, and FibroScan® were used. Results: A statistically significant gender effect was found on HAM-A (B = 0.64, CI: 0.17–1.11) and HAM-D (B = 0.62, CI: 0.14–1.09), with women scoring higher compared to men. Regarding neuropsychological scores, significant differences between gender were identified in executive functions measured by Trail Making Test (TMT B) (B = 0.48, CI: 0.02–0.97), TMT B-A (B = 0.26, CI: −39.2 to −3.7) and in digit span total (B = −0.52, CI: −1.0 to −0.04), with women performing worse than men. Controlling for years of substance dependence, TMT-B and TMT B-A showed significant gender differences. Regarding the presence or absence of substance dependence, only HAM-A and HAM-D remained significant. For categorical variables, Digit Span Total was also influenced by gender, with women being more likely to be impaired: odds ratio (OR) = 7.07, CI: 2.04–24.45), and a trend was observed for Digit Span Backward (OR = 3.57, CI: 1.31–9.75). No significant differences were found between disease severity and neurocognitive performance. Conclusion: Data suggest that gender has an influence on depression, anxiety and cognitive functions with women showing greater impairment compared with men. This effect seems to be influenced by substance dependence.Frontiers MediaRepositório da Universidade de LisboaPires Barreira, DavidMarinho, RuiBicho, ManuelFlores, IsabelFialho, RenataOuakinin, Sílvia2019-11-05T16:05:53Z20192019-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/40079engFrontiers in Psychology | October 2019 | Volume 10 | Article 23171664-107810.3389/fpsyg.2019.02317info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:39:10Zoai:repositorio.ul.pt:10451/40079Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:53:48.930520Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Hepatitis C pretreatment profile and gender differences : cognition and disease severity effects
title Hepatitis C pretreatment profile and gender differences : cognition and disease severity effects
spellingShingle Hepatitis C pretreatment profile and gender differences : cognition and disease severity effects
Pires Barreira, David
Hepatitis C
Neurocognition
Anxiety
Depression
Gender
Disease severity
title_short Hepatitis C pretreatment profile and gender differences : cognition and disease severity effects
title_full Hepatitis C pretreatment profile and gender differences : cognition and disease severity effects
title_fullStr Hepatitis C pretreatment profile and gender differences : cognition and disease severity effects
title_full_unstemmed Hepatitis C pretreatment profile and gender differences : cognition and disease severity effects
title_sort Hepatitis C pretreatment profile and gender differences : cognition and disease severity effects
author Pires Barreira, David
author_facet Pires Barreira, David
Marinho, Rui
Bicho, Manuel
Flores, Isabel
Fialho, Renata
Ouakinin, Sílvia
author_role author
author2 Marinho, Rui
Bicho, Manuel
Flores, Isabel
Fialho, Renata
Ouakinin, Sílvia
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Pires Barreira, David
Marinho, Rui
Bicho, Manuel
Flores, Isabel
Fialho, Renata
Ouakinin, Sílvia
dc.subject.por.fl_str_mv Hepatitis C
Neurocognition
Anxiety
Depression
Gender
Disease severity
topic Hepatitis C
Neurocognition
Anxiety
Depression
Gender
Disease severity
description Copyright © 2019 Barreira, Marinho, Bicho, Flores, Fialho and Ouakinin. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
publishDate 2019
dc.date.none.fl_str_mv 2019-11-05T16:05:53Z
2019
2019-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/40079
url http://hdl.handle.net/10451/40079
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Frontiers in Psychology | October 2019 | Volume 10 | Article 2317
1664-1078
10.3389/fpsyg.2019.02317
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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