Hepatitis C pretreatment profile and gender differences : cognition and disease severity effects
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10451/40079 |
Resumo: | Copyright © 2019 Barreira, Marinho, Bicho, Flores, Fialho and Ouakinin. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
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Hepatitis C pretreatment profile and gender differences : cognition and disease severity effectsHepatitis CNeurocognitionAnxietyDepressionGenderDisease severityCopyright © 2019 Barreira, Marinho, Bicho, Flores, Fialho and Ouakinin. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.Background: The hepatitis C virus (HCV) is known to infect the brain, however, the findings based on associated neuropsychiatric syndrome are controversial and the association itself remains unclear. Gender research in HCV infection is limited, failing to integrate the role of gender differences in neurocognitive syndrome. The aim of this study was to characterize psychological and neurocognitive profiles in HCV-infected patients before treatment and to explore gender differences in those profiles, as well as the impact of disease severity. Methods: A total of 86 patients diagnosed with chronic hepatitis C were included. Depression and anxiety were assessed using Hamilton anxiety scale (HAM-A), Hamilton depression scale (HAM-D), Beck Depression Inventory (BDI). For cognition, a neuropsychological battery to measure attention, concentration and memory was used, and executive function components validated for the Portuguese population was also used before starting treatment. To identify the disease severity, platelet ratio index, and FibroScan® were used. Results: A statistically significant gender effect was found on HAM-A (B = 0.64, CI: 0.17–1.11) and HAM-D (B = 0.62, CI: 0.14–1.09), with women scoring higher compared to men. Regarding neuropsychological scores, significant differences between gender were identified in executive functions measured by Trail Making Test (TMT B) (B = 0.48, CI: 0.02–0.97), TMT B-A (B = 0.26, CI: −39.2 to −3.7) and in digit span total (B = −0.52, CI: −1.0 to −0.04), with women performing worse than men. Controlling for years of substance dependence, TMT-B and TMT B-A showed significant gender differences. Regarding the presence or absence of substance dependence, only HAM-A and HAM-D remained significant. For categorical variables, Digit Span Total was also influenced by gender, with women being more likely to be impaired: odds ratio (OR) = 7.07, CI: 2.04–24.45), and a trend was observed for Digit Span Backward (OR = 3.57, CI: 1.31–9.75). No significant differences were found between disease severity and neurocognitive performance. Conclusion: Data suggest that gender has an influence on depression, anxiety and cognitive functions with women showing greater impairment compared with men. This effect seems to be influenced by substance dependence.Frontiers MediaRepositório da Universidade de LisboaPires Barreira, DavidMarinho, RuiBicho, ManuelFlores, IsabelFialho, RenataOuakinin, Sílvia2019-11-05T16:05:53Z20192019-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/40079engFrontiers in Psychology | October 2019 | Volume 10 | Article 23171664-107810.3389/fpsyg.2019.02317info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:39:10Zoai:repositorio.ul.pt:10451/40079Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:53:48.930520Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Hepatitis C pretreatment profile and gender differences : cognition and disease severity effects |
title |
Hepatitis C pretreatment profile and gender differences : cognition and disease severity effects |
spellingShingle |
Hepatitis C pretreatment profile and gender differences : cognition and disease severity effects Pires Barreira, David Hepatitis C Neurocognition Anxiety Depression Gender Disease severity |
title_short |
Hepatitis C pretreatment profile and gender differences : cognition and disease severity effects |
title_full |
Hepatitis C pretreatment profile and gender differences : cognition and disease severity effects |
title_fullStr |
Hepatitis C pretreatment profile and gender differences : cognition and disease severity effects |
title_full_unstemmed |
Hepatitis C pretreatment profile and gender differences : cognition and disease severity effects |
title_sort |
Hepatitis C pretreatment profile and gender differences : cognition and disease severity effects |
author |
Pires Barreira, David |
author_facet |
Pires Barreira, David Marinho, Rui Bicho, Manuel Flores, Isabel Fialho, Renata Ouakinin, Sílvia |
author_role |
author |
author2 |
Marinho, Rui Bicho, Manuel Flores, Isabel Fialho, Renata Ouakinin, Sílvia |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
Repositório da Universidade de Lisboa |
dc.contributor.author.fl_str_mv |
Pires Barreira, David Marinho, Rui Bicho, Manuel Flores, Isabel Fialho, Renata Ouakinin, Sílvia |
dc.subject.por.fl_str_mv |
Hepatitis C Neurocognition Anxiety Depression Gender Disease severity |
topic |
Hepatitis C Neurocognition Anxiety Depression Gender Disease severity |
description |
Copyright © 2019 Barreira, Marinho, Bicho, Flores, Fialho and Ouakinin. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-11-05T16:05:53Z 2019 2019-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10451/40079 |
url |
http://hdl.handle.net/10451/40079 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Frontiers in Psychology | October 2019 | Volume 10 | Article 2317 1664-1078 10.3389/fpsyg.2019.02317 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Frontiers Media |
publisher.none.fl_str_mv |
Frontiers Media |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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