Excess hospitalizations and mortality associated with seasonal influenza in Portugal, 2008–2018

Detalhes bibliográficos
Autor(a) principal: Froes, Filipe
Data de Publicação: 2022
Outros Autores: Carmo, Mafalda, Lopes, Hugo, Bizouard, Geoffray, Gomes, Catarina, Martins, Margarida, Bricout, Hélène, de Courville, Caroline, de Sousa, Jaime Correia, Rabaçal, Carlos, Raposo, João F., Cordeiro, Carlos Robalo
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/151441
Resumo: Funding Information: The BARI study was funded by Sanofi. Funding Information: CG, MM, HB, and CDC are Sanofi employees. MC, HL, and GB are IQVIA employees. FF, JCDS, CR, JFR, and CRC have received fees from Sanofi. JCDS reports Advisory Board from Boehringer Ingelheim; personal fees and Advisory Board from GSK; grants, personal fees, and Advisory Board from AstraZeneca; personal fees and Advisory Board from Bial; non-financial support from Mundipharma; personal fees from Sanofi; Advisory Board from Novartis, outside the submitted work. FF reports Advisory Board and personal fees from Sanofi, Pfizer, MSD, Gilead and personal fees or non-financial support from Bial, AstraZeneca, GSK, Novartis, Boehringer Ingelheim, Tecnifar, Lilly, Bayer, and Roche outside the submitted work. Publisher Copyright: © 2022, The Author(s).
id RCAP_ecb2f17bf248195f346a39a7e8a0cd1a
oai_identifier_str oai:run.unl.pt:10362/151441
network_acronym_str RCAP
network_name_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository_id_str 7160
spelling Excess hospitalizations and mortality associated with seasonal influenza in Portugal, 2008–2018BurdenCardiovascularExcessHospitalizationInfluenzaMortalityPortugalRespiratoryInfectious DiseasesSDG 3 - Good Health and Well-beingFunding Information: The BARI study was funded by Sanofi. Funding Information: CG, MM, HB, and CDC are Sanofi employees. MC, HL, and GB are IQVIA employees. FF, JCDS, CR, JFR, and CRC have received fees from Sanofi. JCDS reports Advisory Board from Boehringer Ingelheim; personal fees and Advisory Board from GSK; grants, personal fees, and Advisory Board from AstraZeneca; personal fees and Advisory Board from Bial; non-financial support from Mundipharma; personal fees from Sanofi; Advisory Board from Novartis, outside the submitted work. FF reports Advisory Board and personal fees from Sanofi, Pfizer, MSD, Gilead and personal fees or non-financial support from Bial, AstraZeneca, GSK, Novartis, Boehringer Ingelheim, Tecnifar, Lilly, Bayer, and Roche outside the submitted work. Publisher Copyright: © 2022, The Author(s).Background: Influenza can have a domino effect, triggering severe conditions and leading to hospitalization or even death. Since influenza testing is not routinely performed, statistical modeling techniques are increasingly being used to estimate annual hospitalizations and deaths associated with influenza, to overcome the known underestimation from registers coded with influenza-specific diagnosis. The aim of this study was to estimate the clinical and economic burden of severe influenza in Portugal. Methods: The study comprised ten epidemic seasons (2008/09–2017/18) and used two approaches: (i) a direct method of estimating the seasonal influenza hospitalization incidence, based on the number of National Health Service hospitalizations with influenza-specific International Classification of Diseases (ICD) codes (ICD-9: 487–488; ICD-10: J09-J11), as primary or secondary diagnosis; (ii) an indirect method of estimating excess hospitalizations and deaths using broader groups of ICD codes in time-series models, computed for six age groups and four groups of diagnoses: pneumonia or influenza (ICD-9: 480–488, 517.1; ICD-10: J09–J18), respiratory (ICD-9: 460–519; ICD-10: J00–J99), respiratory or cardiovascular (R&C, ICD-9: 390–459, 460–519; ICD-10: I00–I99, J00–J99), and all-cause. Means are reported excluding the H1N1pdm09 pandemic (2009/10). Results: The mean number of hospitalizations coded as due to influenza per season was 1,207, resulting in 11.6 cases per 100,000 people. The mean direct annual cost of these hospitalizations was €3.9 million, of which 78.6% was generated by patients with comorbidities. Mean annual influenza-associated R&C hospitalizations were estimated at 5356 (min: 456; max: 8776), corresponding to 51.5 cases per 100,000 (95% CI: 40.9–62.0) for all age groups and 199.6 (95% CI: 163.9–235.8) for the population aged ≥ 65 years. The mean direct annual cost of the estimated excess R&C hospitalizations was €15.2 million for all age groups and €12.8 million for the population aged ≥ 65 years. Mean annual influenza-associated all-cause deaths per 100,000 people were estimated at 22.7 for all age groups. Conclusions: The study findings suggest that there is an under-detection of influenza in the Portuguese population. A high burden of severe influenza remains to be addressed, not only in the elderly population but also in younger people.Centro de Investigação em Saúde Pública (CISP/PHRC)Comprehensive Health Research Centre (CHRC) - Pólo ENSPNOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)RUNFroes, FilipeCarmo, MafaldaLopes, HugoBizouard, GeoffrayGomes, CatarinaMartins, MargaridaBricout, Hélènede Courville, Carolinede Sousa, Jaime CorreiaRabaçal, CarlosRaposo, João F.Cordeiro, Carlos Robalo2023-03-30T22:20:28Z2022-122022-12-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/151441eng2374-4235PURE: 57307483https://doi.org/10.1186/s12879-022-07713-8info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:33:54Zoai:run.unl.pt:10362/151441Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:54:35.879510Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Excess hospitalizations and mortality associated with seasonal influenza in Portugal, 2008–2018
title Excess hospitalizations and mortality associated with seasonal influenza in Portugal, 2008–2018
spellingShingle Excess hospitalizations and mortality associated with seasonal influenza in Portugal, 2008–2018
Froes, Filipe
Burden
Cardiovascular
Excess
Hospitalization
Influenza
Mortality
Portugal
Respiratory
Infectious Diseases
SDG 3 - Good Health and Well-being
title_short Excess hospitalizations and mortality associated with seasonal influenza in Portugal, 2008–2018
title_full Excess hospitalizations and mortality associated with seasonal influenza in Portugal, 2008–2018
title_fullStr Excess hospitalizations and mortality associated with seasonal influenza in Portugal, 2008–2018
title_full_unstemmed Excess hospitalizations and mortality associated with seasonal influenza in Portugal, 2008–2018
title_sort Excess hospitalizations and mortality associated with seasonal influenza in Portugal, 2008–2018
author Froes, Filipe
author_facet Froes, Filipe
Carmo, Mafalda
Lopes, Hugo
Bizouard, Geoffray
Gomes, Catarina
Martins, Margarida
Bricout, Hélène
de Courville, Caroline
de Sousa, Jaime Correia
Rabaçal, Carlos
Raposo, João F.
Cordeiro, Carlos Robalo
author_role author
author2 Carmo, Mafalda
Lopes, Hugo
Bizouard, Geoffray
Gomes, Catarina
Martins, Margarida
Bricout, Hélène
de Courville, Caroline
de Sousa, Jaime Correia
Rabaçal, Carlos
Raposo, João F.
Cordeiro, Carlos Robalo
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Centro de Investigação em Saúde Pública (CISP/PHRC)
Comprehensive Health Research Centre (CHRC) - Pólo ENSP
NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
RUN
dc.contributor.author.fl_str_mv Froes, Filipe
Carmo, Mafalda
Lopes, Hugo
Bizouard, Geoffray
Gomes, Catarina
Martins, Margarida
Bricout, Hélène
de Courville, Caroline
de Sousa, Jaime Correia
Rabaçal, Carlos
Raposo, João F.
Cordeiro, Carlos Robalo
dc.subject.por.fl_str_mv Burden
Cardiovascular
Excess
Hospitalization
Influenza
Mortality
Portugal
Respiratory
Infectious Diseases
SDG 3 - Good Health and Well-being
topic Burden
Cardiovascular
Excess
Hospitalization
Influenza
Mortality
Portugal
Respiratory
Infectious Diseases
SDG 3 - Good Health and Well-being
description Funding Information: The BARI study was funded by Sanofi. Funding Information: CG, MM, HB, and CDC are Sanofi employees. MC, HL, and GB are IQVIA employees. FF, JCDS, CR, JFR, and CRC have received fees from Sanofi. JCDS reports Advisory Board from Boehringer Ingelheim; personal fees and Advisory Board from GSK; grants, personal fees, and Advisory Board from AstraZeneca; personal fees and Advisory Board from Bial; non-financial support from Mundipharma; personal fees from Sanofi; Advisory Board from Novartis, outside the submitted work. FF reports Advisory Board and personal fees from Sanofi, Pfizer, MSD, Gilead and personal fees or non-financial support from Bial, AstraZeneca, GSK, Novartis, Boehringer Ingelheim, Tecnifar, Lilly, Bayer, and Roche outside the submitted work. Publisher Copyright: © 2022, The Author(s).
publishDate 2022
dc.date.none.fl_str_mv 2022-12
2022-12-01T00:00:00Z
2023-03-30T22:20:28Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/151441
url http://hdl.handle.net/10362/151441
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 2374-4235
PURE: 57307483
https://doi.org/10.1186/s12879-022-07713-8
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
_version_ 1799138134611460096

Registros relacionados