Extensive Investigation on the Effect of Niobium Insertion on the Physical and Biological Properties of 45S5 Bioactive Glass for Dental Implant
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2023 |
| Outros Autores: | , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10362/154843 |
Resumo: | Funding Information: This research was funded by FEDER funds through the COMPETE 2020 Program and National Funds through FCT—Portuguese Foundation for Science and Technology under the project LISBOA-01-0247-FEDER-039985/POCI-01-0247-FEDER-039985, LA/P/0037/2020 of the Associate Laboratory Institute of Nanostructures, Nanomodelling and Nanofabrication—i3N, UIDP/04378/2020 and UIDB/04378/2020 of the Research Unit on Applied Molecular Biosciences—UCIBIO, and LA/P/0140/2020 of the Associate Laboratory Institute for Health and Bioeconomy—i4HB. S.K. Jakka acknowledges FCT—Fundaçao para a Ciência e a Tecnologia, Portugal, I.P., in the scope of the framework contract foreseen in the numbers 4, 5, and 6 of article 23 of the Decree Law 57/2016 of 29 August, changed by Law 57/2017 of 19 July. Publisher Copyright: © 2023 by the authors. |
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Extensive Investigation on the Effect of Niobium Insertion on the Physical and Biological Properties of 45S5 Bioactive Glass for Dental Implantantibacterial propertiesbioactivityBioglassbiomaterialbone regenerationcytotoxicityelectrical propertiesniobium oxideosseointegrationCatalysisMolecular BiologySpectroscopyComputer Science ApplicationsPhysical and Theoretical ChemistryOrganic ChemistryInorganic ChemistryFunding Information: This research was funded by FEDER funds through the COMPETE 2020 Program and National Funds through FCT—Portuguese Foundation for Science and Technology under the project LISBOA-01-0247-FEDER-039985/POCI-01-0247-FEDER-039985, LA/P/0037/2020 of the Associate Laboratory Institute of Nanostructures, Nanomodelling and Nanofabrication—i3N, UIDP/04378/2020 and UIDB/04378/2020 of the Research Unit on Applied Molecular Biosciences—UCIBIO, and LA/P/0140/2020 of the Associate Laboratory Institute for Health and Bioeconomy—i4HB. S.K. Jakka acknowledges FCT—Fundaçao para a Ciência e a Tecnologia, Portugal, I.P., in the scope of the framework contract foreseen in the numbers 4, 5, and 6 of article 23 of the Decree Law 57/2016 of 29 August, changed by Law 57/2017 of 19 July. Publisher Copyright: © 2023 by the authors.Dental implants have emerged as one of the most consistent and predictable treatments in the oral surgery field. However, the placement of the implant is sometimes associated with bacterial infection leading to its loss. In this work, we intend to solve this problem through the development of a biomaterial for implant coatings based on 45S5 Bioglass® modified with different amounts of niobium pentoxide (Nb2O5). The structural feature of the glasses, assessed by XRD and FTIR, did not change in spite of Nb2O5 incorporation. The Raman spectra reveal the Nb2O5 incorporation related to the appearance of NbO4 and NbO6 structural units. Since the electrical characteristics of these biomaterials influence their osseointegration ability, AC and DC electrical conductivity were studied by impedance spectroscopy, in the frequency range of 102–106 Hz and temperature range of 200–400 K. The cytotoxicity of glasses was evaluated using the osteosarcoma Saos-2 cells line. The in vitro bioactivity studies and the antibacterial tests against Gram-positive and Gram-negative bacteria revealed that the samples loaded with 2 mol% Nb2O5 had the highest bioactivity and greatest antibacterial effect. Overall, the results showed that the modified 45S5 bioactive glasses can be used as an antibacterial coating material for implants, with high bioactivity, being also non-cytotoxic to mammalian cells.CENIMAT-i3N - Centro de Investigação de Materiais (Lab. Associado I3N)DF – Departamento de FísicaDCM - Departamento de Ciência dos MateriaisUCIBIO - Applied Molecular Biosciences UnitDCV - Departamento de Ciências da VidaRUNHammami, ImenGavinho, Sílvia RodriguesPádua, Ana SofiaLança, Maria do CarmoBorges, João PauloSilva, Jorge CarvalhoSá-Nogueira, IsabelJakka, Suresh KumarGraça, Manuel Pedro Fernandes2023-07-04T22:17:29Z2023-03-092023-03-09T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article20application/pdfhttp://hdl.handle.net/10362/154843eng1661-6596PURE: 65199338https://doi.org/10.3390/ijms24065244info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:37:18Zoai:run.unl.pt:10362/154843Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:55:47.268289Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
Extensive Investigation on the Effect of Niobium Insertion on the Physical and Biological Properties of 45S5 Bioactive Glass for Dental Implant |
| title |
Extensive Investigation on the Effect of Niobium Insertion on the Physical and Biological Properties of 45S5 Bioactive Glass for Dental Implant |
| spellingShingle |
Extensive Investigation on the Effect of Niobium Insertion on the Physical and Biological Properties of 45S5 Bioactive Glass for Dental Implant Hammami, Imen antibacterial properties bioactivity Bioglass biomaterial bone regeneration cytotoxicity electrical properties niobium oxide osseointegration Catalysis Molecular Biology Spectroscopy Computer Science Applications Physical and Theoretical Chemistry Organic Chemistry Inorganic Chemistry |
| title_short |
Extensive Investigation on the Effect of Niobium Insertion on the Physical and Biological Properties of 45S5 Bioactive Glass for Dental Implant |
| title_full |
Extensive Investigation on the Effect of Niobium Insertion on the Physical and Biological Properties of 45S5 Bioactive Glass for Dental Implant |
| title_fullStr |
Extensive Investigation on the Effect of Niobium Insertion on the Physical and Biological Properties of 45S5 Bioactive Glass for Dental Implant |
| title_full_unstemmed |
Extensive Investigation on the Effect of Niobium Insertion on the Physical and Biological Properties of 45S5 Bioactive Glass for Dental Implant |
| title_sort |
Extensive Investigation on the Effect of Niobium Insertion on the Physical and Biological Properties of 45S5 Bioactive Glass for Dental Implant |
| author |
Hammami, Imen |
| author_facet |
Hammami, Imen Gavinho, Sílvia Rodrigues Pádua, Ana Sofia Lança, Maria do Carmo Borges, João Paulo Silva, Jorge Carvalho Sá-Nogueira, Isabel Jakka, Suresh Kumar Graça, Manuel Pedro Fernandes |
| author_role |
author |
| author2 |
Gavinho, Sílvia Rodrigues Pádua, Ana Sofia Lança, Maria do Carmo Borges, João Paulo Silva, Jorge Carvalho Sá-Nogueira, Isabel Jakka, Suresh Kumar Graça, Manuel Pedro Fernandes |
| author2_role |
author author author author author author author author |
| dc.contributor.none.fl_str_mv |
CENIMAT-i3N - Centro de Investigação de Materiais (Lab. Associado I3N) DF – Departamento de Física DCM - Departamento de Ciência dos Materiais UCIBIO - Applied Molecular Biosciences Unit DCV - Departamento de Ciências da Vida RUN |
| dc.contributor.author.fl_str_mv |
Hammami, Imen Gavinho, Sílvia Rodrigues Pádua, Ana Sofia Lança, Maria do Carmo Borges, João Paulo Silva, Jorge Carvalho Sá-Nogueira, Isabel Jakka, Suresh Kumar Graça, Manuel Pedro Fernandes |
| dc.subject.por.fl_str_mv |
antibacterial properties bioactivity Bioglass biomaterial bone regeneration cytotoxicity electrical properties niobium oxide osseointegration Catalysis Molecular Biology Spectroscopy Computer Science Applications Physical and Theoretical Chemistry Organic Chemistry Inorganic Chemistry |
| topic |
antibacterial properties bioactivity Bioglass biomaterial bone regeneration cytotoxicity electrical properties niobium oxide osseointegration Catalysis Molecular Biology Spectroscopy Computer Science Applications Physical and Theoretical Chemistry Organic Chemistry Inorganic Chemistry |
| description |
Funding Information: This research was funded by FEDER funds through the COMPETE 2020 Program and National Funds through FCT—Portuguese Foundation for Science and Technology under the project LISBOA-01-0247-FEDER-039985/POCI-01-0247-FEDER-039985, LA/P/0037/2020 of the Associate Laboratory Institute of Nanostructures, Nanomodelling and Nanofabrication—i3N, UIDP/04378/2020 and UIDB/04378/2020 of the Research Unit on Applied Molecular Biosciences—UCIBIO, and LA/P/0140/2020 of the Associate Laboratory Institute for Health and Bioeconomy—i4HB. S.K. Jakka acknowledges FCT—Fundaçao para a Ciência e a Tecnologia, Portugal, I.P., in the scope of the framework contract foreseen in the numbers 4, 5, and 6 of article 23 of the Decree Law 57/2016 of 29 August, changed by Law 57/2017 of 19 July. Publisher Copyright: © 2023 by the authors. |
| publishDate |
2023 |
| dc.date.none.fl_str_mv |
2023-07-04T22:17:29Z 2023-03-09 2023-03-09T00:00:00Z |
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info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
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publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10362/154843 |
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http://hdl.handle.net/10362/154843 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
1661-6596 PURE: 65199338 https://doi.org/10.3390/ijms24065244 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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20 application/pdf |
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RCAAP |
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