Bioactive Glass Modified with Zirconium Incorporation for Dental Implant Applications

Detalhes bibliográficos
Autor(a) principal: Hammami, Imen
Data de Publicação: 2023
Outros Autores: Gavinho, Sílvia Rodrigues, Pádua, Ana Sofia, Sá-Nogueira, Isabel, Silva, Jorge Carvalho, Borges, João Paulo, Valente, Manuel Almeida, Graça, Manuel Pedro Fernandes
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/158489
Resumo: This research was funded by FEDER funds through the COMPETE 2020 Program and National Funds through the FCT—Portuguese Foundation for Science and Technology under the projects LISBOA-01-0247-FEDER-039985/POCI-01-0247-FEDER-039985. S.R. Gavinho and A. Sofia Pádua acknowledge the FCT—Portuguese Foundation for Science and Technology for the Ph.D. grant ( UI/DB/151287/2021). Publisher Copyright: © 2023 by the authors.
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spelling Bioactive Glass Modified with Zirconium Incorporation for Dental Implant ApplicationsFabrication, Structural, Electrical, and Biological Analysisantibacterial propertiesbioactivityBioglassdielectric propertiesimplant coatingosseointegrationzirconiumCatalysisMolecular BiologySpectroscopyComputer Science ApplicationsPhysical and Theoretical ChemistryOrganic ChemistryInorganic ChemistryThis research was funded by FEDER funds through the COMPETE 2020 Program and National Funds through the FCT—Portuguese Foundation for Science and Technology under the projects LISBOA-01-0247-FEDER-039985/POCI-01-0247-FEDER-039985. S.R. Gavinho and A. Sofia Pádua acknowledge the FCT—Portuguese Foundation for Science and Technology for the Ph.D. grant ( UI/DB/151287/2021). Publisher Copyright: © 2023 by the authors.Implantology is crucial for restoring aesthetics and masticatory function in oral rehabilitation. Despite its advantages, certain issues, such as bacterial infection, may still arise that hinder osseointegration and result in implant rejection. This work aims to address these challenges by developing a biomaterial for dental implant coating based on 45S5 Bioglass® modified by zirconium insertion. The structural characterization of the glasses, by XRD, showed that the introduction of zirconium in the Bioglass network at a concentration higher than 2 mol% promotes phase separation, with crystal phase formation. Impedance spectroscopy was used, in the frequency range of 102–106 Hz and the temperature range of 200–400 K, to investigate the electrical properties of these Bioglasses, due to their ability to store electrical charges and therefore enhance the osseointegration capacity. The electrical study showed that the presence of crystal phases, in the glass ceramic with 8 mol% of zirconium, led to a significant increase in conductivity. In terms of biological properties, the Bioglasses exhibited an antibacterial effect against Gram-positive and Gram-negative bacteria and did not show cytotoxicity for the Saos-2 cell line at extract concentrations up to 25 mg/mL. Furthermore, the results of the bioactivity test revealed that within 24 h, a CaP-rich layer began to form on the surface of all the samples. According to our results, the incorporation of 2 mol% of ZrO2 into the Bioglass significantly improves its potential as a coating material for dental implants, enhancing both its antibacterial and osteointegration properties.DF – Departamento de FísicaCENIMAT-i3N - Centro de Investigação de Materiais (Lab. Associado I3N)UCIBIO - Applied Molecular Biosciences UnitDCV - Departamento de Ciências da VidaDCM - Departamento de Ciência dos MateriaisRUNHammami, ImenGavinho, Sílvia RodriguesPádua, Ana SofiaSá-Nogueira, IsabelSilva, Jorge CarvalhoBorges, João PauloValente, Manuel AlmeidaGraça, Manuel Pedro Fernandes2023-09-29T22:22:32Z2023-06-242023-06-24T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article17application/pdfhttp://hdl.handle.net/10362/158489eng1661-6596PURE: 72784442https://doi.org/10.3390/ijms241310571info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:40:54Zoai:run.unl.pt:10362/158489Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:57:10.279758Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Bioactive Glass Modified with Zirconium Incorporation for Dental Implant Applications
Fabrication, Structural, Electrical, and Biological Analysis
title Bioactive Glass Modified with Zirconium Incorporation for Dental Implant Applications
spellingShingle Bioactive Glass Modified with Zirconium Incorporation for Dental Implant Applications
Hammami, Imen
antibacterial properties
bioactivity
Bioglass
dielectric properties
implant coating
osseointegration
zirconium
Catalysis
Molecular Biology
Spectroscopy
Computer Science Applications
Physical and Theoretical Chemistry
Organic Chemistry
Inorganic Chemistry
title_short Bioactive Glass Modified with Zirconium Incorporation for Dental Implant Applications
title_full Bioactive Glass Modified with Zirconium Incorporation for Dental Implant Applications
title_fullStr Bioactive Glass Modified with Zirconium Incorporation for Dental Implant Applications
title_full_unstemmed Bioactive Glass Modified with Zirconium Incorporation for Dental Implant Applications
title_sort Bioactive Glass Modified with Zirconium Incorporation for Dental Implant Applications
author Hammami, Imen
author_facet Hammami, Imen
Gavinho, Sílvia Rodrigues
Pádua, Ana Sofia
Sá-Nogueira, Isabel
Silva, Jorge Carvalho
Borges, João Paulo
Valente, Manuel Almeida
Graça, Manuel Pedro Fernandes
author_role author
author2 Gavinho, Sílvia Rodrigues
Pádua, Ana Sofia
Sá-Nogueira, Isabel
Silva, Jorge Carvalho
Borges, João Paulo
Valente, Manuel Almeida
Graça, Manuel Pedro Fernandes
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv DF – Departamento de Física
CENIMAT-i3N - Centro de Investigação de Materiais (Lab. Associado I3N)
UCIBIO - Applied Molecular Biosciences Unit
DCV - Departamento de Ciências da Vida
DCM - Departamento de Ciência dos Materiais
RUN
dc.contributor.author.fl_str_mv Hammami, Imen
Gavinho, Sílvia Rodrigues
Pádua, Ana Sofia
Sá-Nogueira, Isabel
Silva, Jorge Carvalho
Borges, João Paulo
Valente, Manuel Almeida
Graça, Manuel Pedro Fernandes
dc.subject.por.fl_str_mv antibacterial properties
bioactivity
Bioglass
dielectric properties
implant coating
osseointegration
zirconium
Catalysis
Molecular Biology
Spectroscopy
Computer Science Applications
Physical and Theoretical Chemistry
Organic Chemistry
Inorganic Chemistry
topic antibacterial properties
bioactivity
Bioglass
dielectric properties
implant coating
osseointegration
zirconium
Catalysis
Molecular Biology
Spectroscopy
Computer Science Applications
Physical and Theoretical Chemistry
Organic Chemistry
Inorganic Chemistry
description This research was funded by FEDER funds through the COMPETE 2020 Program and National Funds through the FCT—Portuguese Foundation for Science and Technology under the projects LISBOA-01-0247-FEDER-039985/POCI-01-0247-FEDER-039985. S.R. Gavinho and A. Sofia Pádua acknowledge the FCT—Portuguese Foundation for Science and Technology for the Ph.D. grant ( UI/DB/151287/2021). Publisher Copyright: © 2023 by the authors.
publishDate 2023
dc.date.none.fl_str_mv 2023-09-29T22:22:32Z
2023-06-24
2023-06-24T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/158489
url http://hdl.handle.net/10362/158489
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1661-6596
PURE: 72784442
https://doi.org/10.3390/ijms241310571
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 17
application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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