In silico ADMET prediction, evaluation of cytotoxicity in mouse splenocytes and preliminary evaluation of in vitro antimalarial activity of 4-(4-chlorophenyl) thiazole compounds
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10362/164554 |
Resumo: | Funding Information: This study was funded by the Brazilian agencies Fundação de Amparo à Pesquisa do Estado de Pernambuco-FACEPE (Process APQ-0498-4.03/19) and researcher fixation grant-FACEPE (Process BFP-0038-04.03/21). Thanks to MR4, who provided us with the P. falciparum MRA-1029 strain provided by Andrew Talman, Robert Sinden that we used in the trials. The work was partially supported by the FCT project reference CIRCNA/BRB/0281/2019_AMAZING and GHTM-UID/Multi/04413/2013. Funding Information: This study was funded by the Brazilian agencies Fundação de Amparo à Pesquisa do Estado de Pernambuco - FACEPE (Process APQ-0498-4.03/19) and researcher fixation grant -FACEPE (Process BFP -0038-04.03/21). Thanks to MR4, who provided us with the P. falciparum MRA-1029 strain provided by Andrew Talman, Robert Sinden that we used in the trials. The work was partially supported by the FCT project reference CIRCNA/BRB/0281/2019_AMAZING and GHTM-UID/Multi/04413/2013. Publisher Copyright: © 2023, Academia Brasileira de Ciencias. All rights reserved. |
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In silico ADMET prediction, evaluation of cytotoxicity in mouse splenocytes and preliminary evaluation of in vitro antimalarial activity of 4-(4-chlorophenyl) thiazole compoundsADMETantimalarial activitymammalian cell cytotoxicitythiazolesRM Therapeutics. PharmacologyQR MicrobiologyInfectious DiseasesParasitologyDrug DiscoveryPharmacology, Toxicology and Pharmaceutics(all)SDG 3 - Good Health and Well-beingSDG 9 - Industry, Innovation, and InfrastructureFunding Information: This study was funded by the Brazilian agencies Fundação de Amparo à Pesquisa do Estado de Pernambuco-FACEPE (Process APQ-0498-4.03/19) and researcher fixation grant-FACEPE (Process BFP-0038-04.03/21). Thanks to MR4, who provided us with the P. falciparum MRA-1029 strain provided by Andrew Talman, Robert Sinden that we used in the trials. The work was partially supported by the FCT project reference CIRCNA/BRB/0281/2019_AMAZING and GHTM-UID/Multi/04413/2013. Funding Information: This study was funded by the Brazilian agencies Fundação de Amparo à Pesquisa do Estado de Pernambuco - FACEPE (Process APQ-0498-4.03/19) and researcher fixation grant -FACEPE (Process BFP -0038-04.03/21). Thanks to MR4, who provided us with the P. falciparum MRA-1029 strain provided by Andrew Talman, Robert Sinden that we used in the trials. The work was partially supported by the FCT project reference CIRCNA/BRB/0281/2019_AMAZING and GHTM-UID/Multi/04413/2013. Publisher Copyright: © 2023, Academia Brasileira de Ciencias. All rights reserved.In this work, an in silico study and evaluation of the cytotoxicity of 4-(4-chlorophenyl)thiazole compounds against mouse splenocytes and the chloroquinesensitive Plasmodium falciparum 3D7 strain are reported. The in silico results showed that the compounds have important pharmacokinetic properties for compounds with potential drug candidates. Regarding cytotoxicity assays against splenocytes, the compounds have low cytotoxicity. In addition, they were able to promote activation of these cells by increasing nitric oxide production without promoting cell death. Finally, they were able to promote cell proliferation. Regarding the in vitro anti-P. falciparum activity assays, it was observed that the compounds were able to inhibit the parasite’s growth, presenting IC50 values ranging from 0.79 to greater than 10 µM. These results are promising when compared to chloroquine. Therefore, this study showed that 4-(4-chlorophenyl)thiazole compounds are promising candidates for antimalarials.Global Health and Tropical Medicine (GHTM)Instituto de Higiene e Medicina Tropical (IHMT)Vector borne diseases and pathogens (VBD)RUNDA SILVA, Beatriz R.M.G.DA SILVA BEZERRA JÚNIOR, NatanaelDE OLIVEIRA, Jamerson F.Duarte, Denise Maria F.A.Marques, Diego S.C.Nogueira, FátimaDE LIMA, Maria Carmo A.DA CRUZ FILHO, Iranildo José2024-03-06T23:38:28Z20232023-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/164554eng0001-3765PURE: 83793795https://doi.org/10.1590/0001-3765202320230566info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-05-22T18:19:11Zoai:run.unl.pt:10362/164554Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-05-22T18:19:11Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
In silico ADMET prediction, evaluation of cytotoxicity in mouse splenocytes and preliminary evaluation of in vitro antimalarial activity of 4-(4-chlorophenyl) thiazole compounds |
title |
In silico ADMET prediction, evaluation of cytotoxicity in mouse splenocytes and preliminary evaluation of in vitro antimalarial activity of 4-(4-chlorophenyl) thiazole compounds |
spellingShingle |
In silico ADMET prediction, evaluation of cytotoxicity in mouse splenocytes and preliminary evaluation of in vitro antimalarial activity of 4-(4-chlorophenyl) thiazole compounds DA SILVA, Beatriz R.M.G. ADMET antimalarial activity mammalian cell cytotoxicity thiazoles RM Therapeutics. Pharmacology QR Microbiology Infectious Diseases Parasitology Drug Discovery Pharmacology, Toxicology and Pharmaceutics(all) SDG 3 - Good Health and Well-being SDG 9 - Industry, Innovation, and Infrastructure |
title_short |
In silico ADMET prediction, evaluation of cytotoxicity in mouse splenocytes and preliminary evaluation of in vitro antimalarial activity of 4-(4-chlorophenyl) thiazole compounds |
title_full |
In silico ADMET prediction, evaluation of cytotoxicity in mouse splenocytes and preliminary evaluation of in vitro antimalarial activity of 4-(4-chlorophenyl) thiazole compounds |
title_fullStr |
In silico ADMET prediction, evaluation of cytotoxicity in mouse splenocytes and preliminary evaluation of in vitro antimalarial activity of 4-(4-chlorophenyl) thiazole compounds |
title_full_unstemmed |
In silico ADMET prediction, evaluation of cytotoxicity in mouse splenocytes and preliminary evaluation of in vitro antimalarial activity of 4-(4-chlorophenyl) thiazole compounds |
title_sort |
In silico ADMET prediction, evaluation of cytotoxicity in mouse splenocytes and preliminary evaluation of in vitro antimalarial activity of 4-(4-chlorophenyl) thiazole compounds |
author |
DA SILVA, Beatriz R.M.G. |
author_facet |
DA SILVA, Beatriz R.M.G. DA SILVA BEZERRA JÚNIOR, Natanael DE OLIVEIRA, Jamerson F. Duarte, Denise Maria F.A. Marques, Diego S.C. Nogueira, Fátima DE LIMA, Maria Carmo A. DA CRUZ FILHO, Iranildo José |
author_role |
author |
author2 |
DA SILVA BEZERRA JÚNIOR, Natanael DE OLIVEIRA, Jamerson F. Duarte, Denise Maria F.A. Marques, Diego S.C. Nogueira, Fátima DE LIMA, Maria Carmo A. DA CRUZ FILHO, Iranildo José |
author2_role |
author author author author author author author |
dc.contributor.none.fl_str_mv |
Global Health and Tropical Medicine (GHTM) Instituto de Higiene e Medicina Tropical (IHMT) Vector borne diseases and pathogens (VBD) RUN |
dc.contributor.author.fl_str_mv |
DA SILVA, Beatriz R.M.G. DA SILVA BEZERRA JÚNIOR, Natanael DE OLIVEIRA, Jamerson F. Duarte, Denise Maria F.A. Marques, Diego S.C. Nogueira, Fátima DE LIMA, Maria Carmo A. DA CRUZ FILHO, Iranildo José |
dc.subject.por.fl_str_mv |
ADMET antimalarial activity mammalian cell cytotoxicity thiazoles RM Therapeutics. Pharmacology QR Microbiology Infectious Diseases Parasitology Drug Discovery Pharmacology, Toxicology and Pharmaceutics(all) SDG 3 - Good Health and Well-being SDG 9 - Industry, Innovation, and Infrastructure |
topic |
ADMET antimalarial activity mammalian cell cytotoxicity thiazoles RM Therapeutics. Pharmacology QR Microbiology Infectious Diseases Parasitology Drug Discovery Pharmacology, Toxicology and Pharmaceutics(all) SDG 3 - Good Health and Well-being SDG 9 - Industry, Innovation, and Infrastructure |
description |
Funding Information: This study was funded by the Brazilian agencies Fundação de Amparo à Pesquisa do Estado de Pernambuco-FACEPE (Process APQ-0498-4.03/19) and researcher fixation grant-FACEPE (Process BFP-0038-04.03/21). Thanks to MR4, who provided us with the P. falciparum MRA-1029 strain provided by Andrew Talman, Robert Sinden that we used in the trials. The work was partially supported by the FCT project reference CIRCNA/BRB/0281/2019_AMAZING and GHTM-UID/Multi/04413/2013. Funding Information: This study was funded by the Brazilian agencies Fundação de Amparo à Pesquisa do Estado de Pernambuco - FACEPE (Process APQ-0498-4.03/19) and researcher fixation grant -FACEPE (Process BFP -0038-04.03/21). Thanks to MR4, who provided us with the P. falciparum MRA-1029 strain provided by Andrew Talman, Robert Sinden that we used in the trials. The work was partially supported by the FCT project reference CIRCNA/BRB/0281/2019_AMAZING and GHTM-UID/Multi/04413/2013. Publisher Copyright: © 2023, Academia Brasileira de Ciencias. All rights reserved. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023 2023-01-01T00:00:00Z 2024-03-06T23:38:28Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10362/164554 |
url |
http://hdl.handle.net/10362/164554 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
0001-3765 PURE: 83793795 https://doi.org/10.1590/0001-3765202320230566 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
mluisa.alvim@gmail.com |
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1817545993357361152 |