Transthyretin Proteins Regulate Angiogenesis by Conferring Different Molecular Identities to Endothelial Cells

Detalhes bibliográficos
Autor(a) principal: Nunes, Raquel J.
Data de Publicação: 2013
Outros Autores: Oliveira, Paula de, Lages, Ana, Becker, Jörg D., Marcelino, Paulo, Barroso, Eduardo, Perdigoto, Rui, Kelly, Jeffery W., Quintas, Alexandre, Santos, Susana C. R.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.26/6945
Resumo: "This research was originally published in The Journal of Biological Chemistry. Raquel J. Nunes, et al. Transthyretin Proteins Regulate Angiogenesis by Conferring Different Molecular Identities to Endothelial Cells. Journal Name. 2013; 288:31752-31760. © the American Society for Biochemistry and Molecular Biology."
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spelling Transthyretin Proteins Regulate Angiogenesis by Conferring Different Molecular Identities to Endothelial CellsAngiogenesisEndothelial CellFamilial Amyloidotic PolyneuropathyGene ExpressionMicroarrayTransthyretinVascular Biology"This research was originally published in The Journal of Biological Chemistry. Raquel J. Nunes, et al. Transthyretin Proteins Regulate Angiogenesis by Conferring Different Molecular Identities to Endothelial Cells. Journal Name. 2013; 288:31752-31760. © the American Society for Biochemistry and Molecular Biology.""Background: The biological effects of transthyretin proteins on vasculature remain unknown. Results: V30M transthyretin tetramer modulates endothelial global gene expression, down-regulating pro-angiogenic genes, inducing apoptosis and inhibiting migration. Conclusion: Transthyretin proteins regulate angiogenesis by conferring different molecular identities to endothelial cells. Significance: This work has critical implications in the prevention of early hepatic artery thrombosis in familial amyloidotic polyneuropathy patients after liver transplantation."ASBMBRepositório ComumNunes, Raquel J.Oliveira, Paula deLages, AnaBecker, Jörg D.Marcelino, PauloBarroso, EduardoPerdigoto, RuiKelly, Jeffery W.Quintas, AlexandreSantos, Susana C. R.2014-11-06T14:20:47Z2013-11-012013-11-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.26/6945engTHE JOURNAL OF BIOLOGICAL CHEMISTRY VOL. 288, NO. 44, pp. 31752–31760, November 1, 20130021-925810.1074/jbc.M113.469858info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-08-03T02:30:55Zoai:comum.rcaap.pt:10400.26/6945Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T15:06:05.883748Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Transthyretin Proteins Regulate Angiogenesis by Conferring Different Molecular Identities to Endothelial Cells
title Transthyretin Proteins Regulate Angiogenesis by Conferring Different Molecular Identities to Endothelial Cells
spellingShingle Transthyretin Proteins Regulate Angiogenesis by Conferring Different Molecular Identities to Endothelial Cells
Nunes, Raquel J.
Angiogenesis
Endothelial Cell
Familial Amyloidotic Polyneuropathy
Gene Expression
Microarray
Transthyretin
Vascular Biology
title_short Transthyretin Proteins Regulate Angiogenesis by Conferring Different Molecular Identities to Endothelial Cells
title_full Transthyretin Proteins Regulate Angiogenesis by Conferring Different Molecular Identities to Endothelial Cells
title_fullStr Transthyretin Proteins Regulate Angiogenesis by Conferring Different Molecular Identities to Endothelial Cells
title_full_unstemmed Transthyretin Proteins Regulate Angiogenesis by Conferring Different Molecular Identities to Endothelial Cells
title_sort Transthyretin Proteins Regulate Angiogenesis by Conferring Different Molecular Identities to Endothelial Cells
author Nunes, Raquel J.
author_facet Nunes, Raquel J.
Oliveira, Paula de
Lages, Ana
Becker, Jörg D.
Marcelino, Paulo
Barroso, Eduardo
Perdigoto, Rui
Kelly, Jeffery W.
Quintas, Alexandre
Santos, Susana C. R.
author_role author
author2 Oliveira, Paula de
Lages, Ana
Becker, Jörg D.
Marcelino, Paulo
Barroso, Eduardo
Perdigoto, Rui
Kelly, Jeffery W.
Quintas, Alexandre
Santos, Susana C. R.
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório Comum
dc.contributor.author.fl_str_mv Nunes, Raquel J.
Oliveira, Paula de
Lages, Ana
Becker, Jörg D.
Marcelino, Paulo
Barroso, Eduardo
Perdigoto, Rui
Kelly, Jeffery W.
Quintas, Alexandre
Santos, Susana C. R.
dc.subject.por.fl_str_mv Angiogenesis
Endothelial Cell
Familial Amyloidotic Polyneuropathy
Gene Expression
Microarray
Transthyretin
Vascular Biology
topic Angiogenesis
Endothelial Cell
Familial Amyloidotic Polyneuropathy
Gene Expression
Microarray
Transthyretin
Vascular Biology
description "This research was originally published in The Journal of Biological Chemistry. Raquel J. Nunes, et al. Transthyretin Proteins Regulate Angiogenesis by Conferring Different Molecular Identities to Endothelial Cells. Journal Name. 2013; 288:31752-31760. © the American Society for Biochemistry and Molecular Biology."
publishDate 2013
dc.date.none.fl_str_mv 2013-11-01
2013-11-01T00:00:00Z
2014-11-06T14:20:47Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.26/6945
url http://hdl.handle.net/10400.26/6945
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv THE JOURNAL OF BIOLOGICAL CHEMISTRY VOL. 288, NO. 44, pp. 31752–31760, November 1, 2013
0021-9258
10.1074/jbc.M113.469858
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv ASBMB
publisher.none.fl_str_mv ASBMB
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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