Tolerance has its limits: how the thymus copes with infection
Autor(a) principal: | |
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Data de Publicação: | 2013 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | https://hdl.handle.net/1822/25193 |
Resumo: | The thymus is required for T cell differentiation; a process that depends on which antigens are encountered by thymocytes, the environment surrounding the differentiating cells, and the thymic architecture. These features are altered by local infection of the thymus and by the inflammatory mediators that accompany systemic infection. Although once believed to be an immune privileged site, it is now known that antimicrobial responses are recruited to the thymus. Resolving infection in the thymus is important because chronic persistence of microbes impairs the differentiation of pathogen-specific T cells and diminishes resistance to infection. Understanding how these mechanisms contribute to disease susceptibility, particularly in infants with developing T cell repertoires, requires further investigation. |
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Tolerance has its limits: how the thymus copes with infectionThymusInfectionCell repertoireAntimicrobial responseThymic microenvironmentT cell repertoireScience & TechnologyThe thymus is required for T cell differentiation; a process that depends on which antigens are encountered by thymocytes, the environment surrounding the differentiating cells, and the thymic architecture. These features are altered by local infection of the thymus and by the inflammatory mediators that accompany systemic infection. Although once believed to be an immune privileged site, it is now known that antimicrobial responses are recruited to the thymus. Resolving infection in the thymus is important because chronic persistence of microbes impairs the differentiation of pathogen-specific T cells and diminishes resistance to infection. Understanding how these mechanisms contribute to disease susceptibility, particularly in infants with developing T cell repertoires, requires further investigation.We thank Joana Neves and Nadine Santos for critical reading of the manuscript. This work was supported by Portuguese Foundation for Science and Technology (FCT) grant PTDC/SAU-MII/101663/2008 and individual fellowships to CN-A and CN. SMB was supported by National Institutes of Health Grant R01 R56 AI067731.ElsevierUniversidade do MinhoAlves, CláudioNóbrega, CláudiaCorreia-Neves, Margarida20132013-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/1822/25193engNunes-Alves, C., Nobrega, C., Behar, S. M., & Correia-Neves, M. (2013, October). Tolerance has its limits: how the thymus copes with infection. Trends in Immunology. Elsevier BV. http://doi.org/10.1016/j.it.2013.06.0041471-49061471-498110.1016/j.it.2013.06.00423871487http://www.sciencedirect.com/science/article/pii/S147149061300094Xinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:37:45Zoai:repositorium.sdum.uminho.pt:1822/25193Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:34:07.517692Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Tolerance has its limits: how the thymus copes with infection |
title |
Tolerance has its limits: how the thymus copes with infection |
spellingShingle |
Tolerance has its limits: how the thymus copes with infection Alves, Cláudio Thymus Infection Cell repertoire Antimicrobial response Thymic microenvironment T cell repertoire Science & Technology |
title_short |
Tolerance has its limits: how the thymus copes with infection |
title_full |
Tolerance has its limits: how the thymus copes with infection |
title_fullStr |
Tolerance has its limits: how the thymus copes with infection |
title_full_unstemmed |
Tolerance has its limits: how the thymus copes with infection |
title_sort |
Tolerance has its limits: how the thymus copes with infection |
author |
Alves, Cláudio |
author_facet |
Alves, Cláudio Nóbrega, Cláudia Correia-Neves, Margarida |
author_role |
author |
author2 |
Nóbrega, Cláudia Correia-Neves, Margarida |
author2_role |
author author |
dc.contributor.none.fl_str_mv |
Universidade do Minho |
dc.contributor.author.fl_str_mv |
Alves, Cláudio Nóbrega, Cláudia Correia-Neves, Margarida |
dc.subject.por.fl_str_mv |
Thymus Infection Cell repertoire Antimicrobial response Thymic microenvironment T cell repertoire Science & Technology |
topic |
Thymus Infection Cell repertoire Antimicrobial response Thymic microenvironment T cell repertoire Science & Technology |
description |
The thymus is required for T cell differentiation; a process that depends on which antigens are encountered by thymocytes, the environment surrounding the differentiating cells, and the thymic architecture. These features are altered by local infection of the thymus and by the inflammatory mediators that accompany systemic infection. Although once believed to be an immune privileged site, it is now known that antimicrobial responses are recruited to the thymus. Resolving infection in the thymus is important because chronic persistence of microbes impairs the differentiation of pathogen-specific T cells and diminishes resistance to infection. Understanding how these mechanisms contribute to disease susceptibility, particularly in infants with developing T cell repertoires, requires further investigation. |
publishDate |
2013 |
dc.date.none.fl_str_mv |
2013 2013-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://hdl.handle.net/1822/25193 |
url |
https://hdl.handle.net/1822/25193 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Nunes-Alves, C., Nobrega, C., Behar, S. M., & Correia-Neves, M. (2013, October). Tolerance has its limits: how the thymus copes with infection. Trends in Immunology. Elsevier BV. http://doi.org/10.1016/j.it.2013.06.004 1471-4906 1471-4981 10.1016/j.it.2013.06.004 23871487 http://www.sciencedirect.com/science/article/pii/S147149061300094X |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier |
publisher.none.fl_str_mv |
Elsevier |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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