A randomized controlled trial of a weight loss maintenance program in adults with obesity
Autor(a) principal: | |
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Data de Publicação: | 2024 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10362/168911 |
Resumo: | Funding Information: This work was sponsored by Farmodietica S.A. The study was also promoted by the CINTESIS@RISE, NOVA Medical School, NOVA University of Lisbon and financed by national funds through FCT Fundacao para a Ciencia e a Technologia, I.P., within the scope of the project \u201CRISE \u2013 LA/P/0053/2020\u201D. The sponsor and funder had no role in the study design and had no role during its execution, analysis, interpretation of the data, or decision to submit the results. Publisher Copyright: © The Author(s), under exclusive licence to Springer Nature Limited 2024. |
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A randomized controlled trial of a weight loss maintenance program in adults with obesitythe WLM3P studyLifestyle-based intensive interventionObesityWeight lossWeight maintenanceMedicine (miscellaneous)Nutrition and DieteticsSDG 3 - Good Health and Well-beingFunding Information: This work was sponsored by Farmodietica S.A. The study was also promoted by the CINTESIS@RISE, NOVA Medical School, NOVA University of Lisbon and financed by national funds through FCT Fundacao para a Ciencia e a Technologia, I.P., within the scope of the project \u201CRISE \u2013 LA/P/0053/2020\u201D. The sponsor and funder had no role in the study design and had no role during its execution, analysis, interpretation of the data, or decision to submit the results. Publisher Copyright: © The Author(s), under exclusive licence to Springer Nature Limited 2024.Background/Objectives: The escalating obesity epidemic necessitates effective, sustainable weight loss (WL) and maintenance strategies. This study aimed to evaluate the effectiveness of the Weight Loss Maintenance 3 Phases Program (WLM3P) in achieving a clinically significant long-term weight loss (WL) (≥5% initial WL at 18 months) in adults with obesity compared to a standard low-carbohydrate diet (LCD). Subjects/Methods: In this two-phase trial, 112 participants targeting initial WL (0–6 months) and subsequent maintenance (7–18 months) were randomly assigned to either WLM3P or LCD groups. Outcomes assessed included change in body weight (kg, %), improvements in body composition, and metabolic profile. Results: Of 112 randomized participants, 69% (n = 77) completed the study. At 18 months, WL in the WLM3P group (n = 40) was 15.5 ± 8.3% compared to 9.6 ± 8.5% in the LCD group (n = 37) (p < 0.001). The odds ratio of achieving WL ≥ 10% and ≥15% were significantly higher in the WLM3P group. Complete-case analysis revealed significantly greater improvements in BMI, body fat mass, visceral fat area, waist circumference, waist-to-hip ratio, HDL, and triglyceride/HDL ratio in WLM3P than in LCD. No serious adverse events were reported. Conclusion: Both programs effectively promoted clinically relevant WL and its maintenance. However, the WLM3P program was more successful in helping participants achieve greater WL targets of ≥10% and ≥15%, along with other clinical benefits, after an 18-month intervention. Trial registration number: NCT04192357.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)Comprehensive Health Research Centre (CHRC) - pólo NMSCentro de Investigação em Tecnologias e Serviços de Saúde (CINTESIS)RUNPereira, VanessaBarreiros-Mota, InêsCortez, FilipaCastela, InêsTeixeira, DianaCalhau, ConceiçãoCamila Dias, CláudiaMoreira-Rosário, AndréSilvestre, Marta P.2024-06-21T22:26:07Z20242024-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/168911eng0954-3007PURE: 93698399https://doi.org/10.1038/s41430-024-01454-4info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-09-23T01:38:35Zoai:run.unl.pt:10362/168911Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-09-23T01:38:35Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
A randomized controlled trial of a weight loss maintenance program in adults with obesity the WLM3P study |
title |
A randomized controlled trial of a weight loss maintenance program in adults with obesity |
spellingShingle |
A randomized controlled trial of a weight loss maintenance program in adults with obesity Pereira, Vanessa Lifestyle-based intensive intervention Obesity Weight loss Weight maintenance Medicine (miscellaneous) Nutrition and Dietetics SDG 3 - Good Health and Well-being |
title_short |
A randomized controlled trial of a weight loss maintenance program in adults with obesity |
title_full |
A randomized controlled trial of a weight loss maintenance program in adults with obesity |
title_fullStr |
A randomized controlled trial of a weight loss maintenance program in adults with obesity |
title_full_unstemmed |
A randomized controlled trial of a weight loss maintenance program in adults with obesity |
title_sort |
A randomized controlled trial of a weight loss maintenance program in adults with obesity |
author |
Pereira, Vanessa |
author_facet |
Pereira, Vanessa Barreiros-Mota, Inês Cortez, Filipa Castela, Inês Teixeira, Diana Calhau, Conceição Camila Dias, Cláudia Moreira-Rosário, André Silvestre, Marta P. |
author_role |
author |
author2 |
Barreiros-Mota, Inês Cortez, Filipa Castela, Inês Teixeira, Diana Calhau, Conceição Camila Dias, Cláudia Moreira-Rosário, André Silvestre, Marta P. |
author2_role |
author author author author author author author author |
dc.contributor.none.fl_str_mv |
NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM) Comprehensive Health Research Centre (CHRC) - pólo NMS Centro de Investigação em Tecnologias e Serviços de Saúde (CINTESIS) RUN |
dc.contributor.author.fl_str_mv |
Pereira, Vanessa Barreiros-Mota, Inês Cortez, Filipa Castela, Inês Teixeira, Diana Calhau, Conceição Camila Dias, Cláudia Moreira-Rosário, André Silvestre, Marta P. |
dc.subject.por.fl_str_mv |
Lifestyle-based intensive intervention Obesity Weight loss Weight maintenance Medicine (miscellaneous) Nutrition and Dietetics SDG 3 - Good Health and Well-being |
topic |
Lifestyle-based intensive intervention Obesity Weight loss Weight maintenance Medicine (miscellaneous) Nutrition and Dietetics SDG 3 - Good Health and Well-being |
description |
Funding Information: This work was sponsored by Farmodietica S.A. The study was also promoted by the CINTESIS@RISE, NOVA Medical School, NOVA University of Lisbon and financed by national funds through FCT Fundacao para a Ciencia e a Technologia, I.P., within the scope of the project \u201CRISE \u2013 LA/P/0053/2020\u201D. The sponsor and funder had no role in the study design and had no role during its execution, analysis, interpretation of the data, or decision to submit the results. Publisher Copyright: © The Author(s), under exclusive licence to Springer Nature Limited 2024. |
publishDate |
2024 |
dc.date.none.fl_str_mv |
2024-06-21T22:26:07Z 2024 2024-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10362/168911 |
url |
http://hdl.handle.net/10362/168911 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
0954-3007 PURE: 93698399 https://doi.org/10.1038/s41430-024-01454-4 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
mluisa.alvim@gmail.com |
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1817546128354181120 |