In Vitro Activity of Quaternary Ammonium Surfactants against Streptococcal, Chlamydial, and Gonococcal Infective Agents

Detalhes bibliográficos
Autor(a) principal: Inácio, Ângela S.
Data de Publicação: 2016
Outros Autores: Nunes, Alexandra, Milho, Catarina, Mota, Luís Jaime, Borrego, Maria J., Gomes, João P., Vaz, Winchil L.C., Vieira, Otília V.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.18/4189
Resumo: Free PMC Article: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4879390/
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spelling In Vitro Activity of Quaternary Ammonium Surfactants against Streptococcal, Chlamydial, and Gonococcal Infective AgentsQuaternary Ammonium SurfactantsSexually Transmitted InfectionsInfecções Sexualmente TransmissíveisFree PMC Article: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4879390/Quaternary ammonium compounds (QAC) are widely used, cheap, and chemically stable disinfectants and topical antiseptics with wide-spectrum antimicrobial activities. Within this group of compounds, we recently showed that there are significant differences between the pharmacodynamics of n-alkyl quaternary ammonium surfactants (QAS) with a short (C12) alkyl chain when in vitro toxicities toward bacterial and mammalian epithelial cells are compared. These differences result in an attractive therapeutic window that justifies studying short-chain QAS as prophylactics for sexually transmitted infections (STI) and perinatal vertically transmitted urogenital infections (UGI). We have evaluated the antimicrobial activities of short-chain (C12) n-alkyl QAS against several STI and UGI pathogens as well as against commensal Lactobacillus species. Inhibition of infection of HeLa cells by Neisseria gonorrhoeae and Chlamydia trachomatis was studied at concentrations that were not toxic to the HeLa cells. We show that the pathogenic bacteria are much more susceptible to QAS toxic effects than the commensal vaginal flora and that QAS significantly attenuate the infectivity of N. gonorrhoeae and C. trachomatis without affecting the viability of epithelial cells of the vaginal mucosa. N-Dodecylpyridinium bromide (C12PB) was found to be the most effective QAS. Our results strongly suggest that short-chain (C12) n-alkyl pyridinium bromides and structurally similar compounds are promising microbicide candidates for topical application in the prophylaxis of STI and perinatal vertical transmission of UGI.This work, including the efforts of Otilia V. Vieira, was funded by FCT (PTDC/BIA-BCM/112138/2009). This work, including the efforts of Otilia V. Vieira, was funded by FCT (HMSP-ICT/0024/2010). This work, including the efforts of Otilia V. Vieira, was funded by FCT (iNOVA4Health - UID/Multi/04462/2013).American Society for MicrobiologyRepositório Científico do Instituto Nacional de SaúdeInácio, Ângela S.Nunes, AlexandraMilho, CatarinaMota, Luís JaimeBorrego, Maria J.Gomes, João P.Vaz, Winchil L.C.Vieira, Otília V.2017-02-15T17:42:33Z2016-05-232016-05-23T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.18/4189engAntimicrob Agents Chemother. 2016 Jun;60(6):3323-32. doi: 10.1128/AAC.00166-16. Epub 2016 May 230066-480410.1128/AAC.00166-16info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-20T15:40:20Zoai:repositorio.insa.pt:10400.18/4189Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:39:13.187995Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv In Vitro Activity of Quaternary Ammonium Surfactants against Streptococcal, Chlamydial, and Gonococcal Infective Agents
title In Vitro Activity of Quaternary Ammonium Surfactants against Streptococcal, Chlamydial, and Gonococcal Infective Agents
spellingShingle In Vitro Activity of Quaternary Ammonium Surfactants against Streptococcal, Chlamydial, and Gonococcal Infective Agents
Inácio, Ângela S.
Quaternary Ammonium Surfactants
Sexually Transmitted Infections
Infecções Sexualmente Transmissíveis
title_short In Vitro Activity of Quaternary Ammonium Surfactants against Streptococcal, Chlamydial, and Gonococcal Infective Agents
title_full In Vitro Activity of Quaternary Ammonium Surfactants against Streptococcal, Chlamydial, and Gonococcal Infective Agents
title_fullStr In Vitro Activity of Quaternary Ammonium Surfactants against Streptococcal, Chlamydial, and Gonococcal Infective Agents
title_full_unstemmed In Vitro Activity of Quaternary Ammonium Surfactants against Streptococcal, Chlamydial, and Gonococcal Infective Agents
title_sort In Vitro Activity of Quaternary Ammonium Surfactants against Streptococcal, Chlamydial, and Gonococcal Infective Agents
author Inácio, Ângela S.
author_facet Inácio, Ângela S.
Nunes, Alexandra
Milho, Catarina
Mota, Luís Jaime
Borrego, Maria J.
Gomes, João P.
Vaz, Winchil L.C.
Vieira, Otília V.
author_role author
author2 Nunes, Alexandra
Milho, Catarina
Mota, Luís Jaime
Borrego, Maria J.
Gomes, João P.
Vaz, Winchil L.C.
Vieira, Otília V.
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório Científico do Instituto Nacional de Saúde
dc.contributor.author.fl_str_mv Inácio, Ângela S.
Nunes, Alexandra
Milho, Catarina
Mota, Luís Jaime
Borrego, Maria J.
Gomes, João P.
Vaz, Winchil L.C.
Vieira, Otília V.
dc.subject.por.fl_str_mv Quaternary Ammonium Surfactants
Sexually Transmitted Infections
Infecções Sexualmente Transmissíveis
topic Quaternary Ammonium Surfactants
Sexually Transmitted Infections
Infecções Sexualmente Transmissíveis
description Free PMC Article: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4879390/
publishDate 2016
dc.date.none.fl_str_mv 2016-05-23
2016-05-23T00:00:00Z
2017-02-15T17:42:33Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.18/4189
url http://hdl.handle.net/10400.18/4189
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Antimicrob Agents Chemother. 2016 Jun;60(6):3323-32. doi: 10.1128/AAC.00166-16. Epub 2016 May 23
0066-4804
10.1128/AAC.00166-16
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv American Society for Microbiology
publisher.none.fl_str_mv American Society for Microbiology
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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