In vitro activity of quaternary ammonium surfactants against streptococcal, chlamydial, and gonococcal infective agents

Detalhes bibliográficos
Autor(a) principal: Inácio, Angela S.
Data de Publicação: 2016
Outros Autores: Nunes, Alexandra, Milho, Catarina, Mota, Luís Jaime, Borrego, Maria J., Gomes, João P., Vaz, Winchil L C, Vieira, Otília V.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: https://doi.org/10.1128/AAC.00166-16
Resumo: This work, including the efforts of Otilia V. Vieira, was funded by FCT (PTDC/BIA-BCM/112138/2009). This work, including the efforts of Otilia V. Vieira, was funded by FCT (HMSP-ICT/0024/2010). This work, including the efforts of Otilia V. Vieira, was funded by FCT (iNOVA4Health - UID/Multi/04462/2013).
id RCAP_f326609fa64c0247607cbcca445cfe0d
oai_identifier_str oai:run.unl.pt:10362/35831
network_acronym_str RCAP
network_name_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository_id_str 7160
spelling In vitro activity of quaternary ammonium surfactants against streptococcal, chlamydial, and gonococcal infective agentsNEISSERIA-GONORRHOEAE INFECTIONVAGINAL EPITHELIAL-CELLSBACTERIAL VAGINOSISHIV TRANSMISSIONMICROBICIDESTOXICITYPROLIFERATIONEPIDEMIOLOGYPREVENTIONPharmacologyInfectious DiseasesPharmacology (medical)SDG 3 - Good Health and Well-beingThis work, including the efforts of Otilia V. Vieira, was funded by FCT (PTDC/BIA-BCM/112138/2009). This work, including the efforts of Otilia V. Vieira, was funded by FCT (HMSP-ICT/0024/2010). This work, including the efforts of Otilia V. Vieira, was funded by FCT (iNOVA4Health - UID/Multi/04462/2013).Quaternary ammonium compounds (QAC) are widely used, cheap, and chemically stable disinfectants and topical antiseptics with wide-spectrum antimicrobial activities. Within this group of compounds, we recently showed that there are significant differences between the pharmacodynamics of n-alkyl quaternary ammonium surfactants (QAS) with a short (C12 ) alkyl chain when in vitro toxicities toward bacterial and mammalian epithelial cells are compared. These differences result in an attractive therapeutic window that justifies studying short-chain QAS as prophylactics for sexually transmitted infections (STI) and perinatal vertically transmitted urogenital infections (UGI). We have evaluated the antimicrobial activities of short-chain (C12 ) n-alkyl QAS against several STI and UGI pathogens as well as against commensal Lactobacillus species. Inhibition of infection of HeLa cells by Neisseria gonorrhoeae and Chlamydia trachomatis was studied at concentrations that were not toxic to the HeLa cells. We show that the pathogenic bacteria are much more susceptible to QAS toxic effects than the commensal vaginal flora and that QAS significantly attenuate the infectivity of N. gonorrhoeae and C. trachomatis without affecting the viability of epithelial cells of the vaginal mucosa. N-Dodecylpyridinium bromide (C12 PB) was found to be the most effective QAS. Our results strongly suggest that short-chain (C12 ) n-alkyl pyridinium bromides and structurally similar compounds are promising microbicide candidates for topical application in the prophylaxis of STI and perinatal vertical transmission of UGI.UCIBIO - Applied Molecular Biosciences UnitDCV - Departamento de Ciências da VidaInstituto de Tecnologia Química e Biológica António Xavier (ITQB)NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)Centro de Estudos de Doenças Crónicas (CEDOC)RUNInácio, Angela S.Nunes, AlexandraMilho, CatarinaMota, Luís JaimeBorrego, Maria J.Gomes, João P.Vaz, Winchil L CVieira, Otília V.2018-05-02T22:03:12Z2016-062016-06-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10application/pdfhttps://doi.org/10.1128/AAC.00166-16eng0066-4804PURE: 1217472http://www.scopus.com/inward/record.url?scp=84973662058&partnerID=8YFLogxKhttps://doi.org/10.1128/AAC.00166-16info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T04:19:30Zoai:run.unl.pt:10362/35831Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:30:22.512099Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv In vitro activity of quaternary ammonium surfactants against streptococcal, chlamydial, and gonococcal infective agents
title In vitro activity of quaternary ammonium surfactants against streptococcal, chlamydial, and gonococcal infective agents
spellingShingle In vitro activity of quaternary ammonium surfactants against streptococcal, chlamydial, and gonococcal infective agents
Inácio, Angela S.
NEISSERIA-GONORRHOEAE INFECTION
VAGINAL EPITHELIAL-CELLS
BACTERIAL VAGINOSIS
HIV TRANSMISSION
MICROBICIDES
TOXICITY
PROLIFERATION
EPIDEMIOLOGY
PREVENTION
Pharmacology
Infectious Diseases
Pharmacology (medical)
SDG 3 - Good Health and Well-being
title_short In vitro activity of quaternary ammonium surfactants against streptococcal, chlamydial, and gonococcal infective agents
title_full In vitro activity of quaternary ammonium surfactants against streptococcal, chlamydial, and gonococcal infective agents
title_fullStr In vitro activity of quaternary ammonium surfactants against streptococcal, chlamydial, and gonococcal infective agents
title_full_unstemmed In vitro activity of quaternary ammonium surfactants against streptococcal, chlamydial, and gonococcal infective agents
title_sort In vitro activity of quaternary ammonium surfactants against streptococcal, chlamydial, and gonococcal infective agents
author Inácio, Angela S.
author_facet Inácio, Angela S.
Nunes, Alexandra
Milho, Catarina
Mota, Luís Jaime
Borrego, Maria J.
Gomes, João P.
Vaz, Winchil L C
Vieira, Otília V.
author_role author
author2 Nunes, Alexandra
Milho, Catarina
Mota, Luís Jaime
Borrego, Maria J.
Gomes, João P.
Vaz, Winchil L C
Vieira, Otília V.
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv UCIBIO - Applied Molecular Biosciences Unit
DCV - Departamento de Ciências da Vida
Instituto de Tecnologia Química e Biológica António Xavier (ITQB)
NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
Centro de Estudos de Doenças Crónicas (CEDOC)
RUN
dc.contributor.author.fl_str_mv Inácio, Angela S.
Nunes, Alexandra
Milho, Catarina
Mota, Luís Jaime
Borrego, Maria J.
Gomes, João P.
Vaz, Winchil L C
Vieira, Otília V.
dc.subject.por.fl_str_mv NEISSERIA-GONORRHOEAE INFECTION
VAGINAL EPITHELIAL-CELLS
BACTERIAL VAGINOSIS
HIV TRANSMISSION
MICROBICIDES
TOXICITY
PROLIFERATION
EPIDEMIOLOGY
PREVENTION
Pharmacology
Infectious Diseases
Pharmacology (medical)
SDG 3 - Good Health and Well-being
topic NEISSERIA-GONORRHOEAE INFECTION
VAGINAL EPITHELIAL-CELLS
BACTERIAL VAGINOSIS
HIV TRANSMISSION
MICROBICIDES
TOXICITY
PROLIFERATION
EPIDEMIOLOGY
PREVENTION
Pharmacology
Infectious Diseases
Pharmacology (medical)
SDG 3 - Good Health and Well-being
description This work, including the efforts of Otilia V. Vieira, was funded by FCT (PTDC/BIA-BCM/112138/2009). This work, including the efforts of Otilia V. Vieira, was funded by FCT (HMSP-ICT/0024/2010). This work, including the efforts of Otilia V. Vieira, was funded by FCT (iNOVA4Health - UID/Multi/04462/2013).
publishDate 2016
dc.date.none.fl_str_mv 2016-06
2016-06-01T00:00:00Z
2018-05-02T22:03:12Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://doi.org/10.1128/AAC.00166-16
url https://doi.org/10.1128/AAC.00166-16
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 0066-4804
PURE: 1217472
http://www.scopus.com/inward/record.url?scp=84973662058&partnerID=8YFLogxK
https://doi.org/10.1128/AAC.00166-16
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 10
application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
_version_ 1799137928498118656

Registros relacionados