A Transcriptomic Approach to the Recruitment of Venom Proteins in a Marine Annelid

Detalhes bibliográficos
Autor(a) principal: Rodrigo, Ana P.
Data de Publicação: 2021
Outros Autores: Grosso, Ana R., Baptista, Pedro V., Fernandes, Alexandra R., Costa, Pedro M.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/123685
Resumo: CEECIND/02699/2017
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spelling A Transcriptomic Approach to the Recruitment of Venom Proteins in a Marine AnnelidAnnelidamarine environmentprotein recruitmentselective pressuretoxinswhole-transcriptome sequencingToxicologyHealth, Toxicology and MutagenesisSDG 14 - Life Below WaterCEECIND/02699/2017The growing number of known venomous marine invertebrates indicates that chemical warfare plays an important role in adapting to diversified ecological niches, even though it remains unclear how toxins fit into the evolutionary history of these animals. Our case study, the Polychaeta Eulalia sp., is an intertidal predator that secretes toxins. Whole-transcriptome sequencing revealed proteinaceous toxins secreted by cells in the proboscis and delivered by mucus. Toxins and accompanying enzymes promote permeabilization, coagulation impairment and the blocking of the neuromuscular activity of prey upon which the worm feeds by sucking pieces of live flesh. The main neurotoxins ("phyllotoxins") were found to be cysteine-rich proteins, a class of substances ubiquitous among venomous animals. Some toxins were phylogenetically related to Polychaeta, Mollusca or more ancient groups, such as Cnidaria. Some toxins may have evolved from non-toxin homologs that were recruited without the reduction in molecular mass and increased specificity of other invertebrate toxins. By analyzing the phylogeny of toxin mixtures, we show that Polychaeta is uniquely positioned in the evolution of animal venoms. Indeed, the phylogenetic models of mixed or individual toxins do not follow the expected eumetazoan tree-of-life and highlight that the recruitment of gene products for a role in venom systems is complex.UCIBIO - Applied Molecular Biosciences UnitDCV - Departamento de Ciências da VidaRUNRodrigo, Ana P.Grosso, Ana R.Baptista, Pedro V.Fernandes, Alexandra R.Costa, Pedro M.2021-09-03T00:12:06Z2021-01-282021-01-28T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/123685eng2072-6651PURE: 28408528https://doi.org/10.3390/toxins13020097info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:05:01Zoai:run.unl.pt:10362/123685Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:45:08.704406Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv A Transcriptomic Approach to the Recruitment of Venom Proteins in a Marine Annelid
title A Transcriptomic Approach to the Recruitment of Venom Proteins in a Marine Annelid
spellingShingle A Transcriptomic Approach to the Recruitment of Venom Proteins in a Marine Annelid
Rodrigo, Ana P.
Annelida
marine environment
protein recruitment
selective pressure
toxins
whole-transcriptome sequencing
Toxicology
Health, Toxicology and Mutagenesis
SDG 14 - Life Below Water
title_short A Transcriptomic Approach to the Recruitment of Venom Proteins in a Marine Annelid
title_full A Transcriptomic Approach to the Recruitment of Venom Proteins in a Marine Annelid
title_fullStr A Transcriptomic Approach to the Recruitment of Venom Proteins in a Marine Annelid
title_full_unstemmed A Transcriptomic Approach to the Recruitment of Venom Proteins in a Marine Annelid
title_sort A Transcriptomic Approach to the Recruitment of Venom Proteins in a Marine Annelid
author Rodrigo, Ana P.
author_facet Rodrigo, Ana P.
Grosso, Ana R.
Baptista, Pedro V.
Fernandes, Alexandra R.
Costa, Pedro M.
author_role author
author2 Grosso, Ana R.
Baptista, Pedro V.
Fernandes, Alexandra R.
Costa, Pedro M.
author2_role author
author
author
author
dc.contributor.none.fl_str_mv UCIBIO - Applied Molecular Biosciences Unit
DCV - Departamento de Ciências da Vida
RUN
dc.contributor.author.fl_str_mv Rodrigo, Ana P.
Grosso, Ana R.
Baptista, Pedro V.
Fernandes, Alexandra R.
Costa, Pedro M.
dc.subject.por.fl_str_mv Annelida
marine environment
protein recruitment
selective pressure
toxins
whole-transcriptome sequencing
Toxicology
Health, Toxicology and Mutagenesis
SDG 14 - Life Below Water
topic Annelida
marine environment
protein recruitment
selective pressure
toxins
whole-transcriptome sequencing
Toxicology
Health, Toxicology and Mutagenesis
SDG 14 - Life Below Water
description CEECIND/02699/2017
publishDate 2021
dc.date.none.fl_str_mv 2021-09-03T00:12:06Z
2021-01-28
2021-01-28T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/123685
url http://hdl.handle.net/10362/123685
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 2072-6651
PURE: 28408528
https://doi.org/10.3390/toxins13020097
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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