The role of chitosan membranes on scarring process following lumbar surgery :post-laminectomy experimental model

Detalhes bibliográficos
Autor(a) principal: Carvalho, Miguel Trigo de
Data de Publicação: 2012
Tipo de documento: Dissertação
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10316/31364
Resumo: Dissertação de mestrado em Patologia Experimental, apresentada à Faculdade de Medicina da Universidade de Coimbra
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spelling The role of chitosan membranes on scarring process following lumbar surgery :post-laminectomy experimental modelVértebras lombares - cirurgiaQuitosanoLaminectomiaModelos animais de doençasCoelhosDissertação de mestrado em Patologia Experimental, apresentada à Faculdade de Medicina da Universidade de CoimbraIntroduction: Post-operative scarring process on lumbar surgery is object of several studies mainly because of the epidural fibrosis formation. Chitosan have shown promising effect fibrosis prevention. The aim of this study is to determine the influence chitosan-silane membrane on the lumbar surgery scarring process. These membranes have improved mechanical strength which makes it suitable to mantain a predefined shape. Materials/methods: Fourteen New Zealand male rabbits underwent two level lumbar laminectomy. Laminectomy sites were randomly selected for biomaterial or control. Chitosan membranes were prepared and care was taken in order to make it adapted to the bone defect dimensions in a way that it covered the totality of the defect and also the bone margins. Histological analysis was performed by haematoxylin/eosin and by Masson’s trichrome staining four weeks after laminectomy. Results: Microscope observations revealed the presence of a wellorganized regenerating tissue, integrated in the surrounding vertebral bone tissue with a regular and all-site interface on the chitosan sites, in clear contrast with the presence of a disorganized regenerating tissue with aspects consistent with the persistence of a chronic inflammatory condition, on control sites. Conclusions: The results of this study clearly demonstrated that chitosan had an organizing effect on post-operative scarring process. The presence of the chitosan membrane resulted on a well-organized tissue integrated in the surrounding vertebral bone tissue with signs of regenerative bone tissue in continuity with native bone. This can be a major feature on the dynamics of epidural fibrosis formation2012info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesishttp://hdl.handle.net/10316/31364http://hdl.handle.net/10316/31364engCarvalho, Miguel Trigo deinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-01-20T17:48:47Zoai:estudogeral.uc.pt:10316/31364Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:44:48.525954Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv The role of chitosan membranes on scarring process following lumbar surgery :post-laminectomy experimental model
title The role of chitosan membranes on scarring process following lumbar surgery :post-laminectomy experimental model
spellingShingle The role of chitosan membranes on scarring process following lumbar surgery :post-laminectomy experimental model
Carvalho, Miguel Trigo de
Vértebras lombares - cirurgia
Quitosano
Laminectomia
Modelos animais de doenças
Coelhos
title_short The role of chitosan membranes on scarring process following lumbar surgery :post-laminectomy experimental model
title_full The role of chitosan membranes on scarring process following lumbar surgery :post-laminectomy experimental model
title_fullStr The role of chitosan membranes on scarring process following lumbar surgery :post-laminectomy experimental model
title_full_unstemmed The role of chitosan membranes on scarring process following lumbar surgery :post-laminectomy experimental model
title_sort The role of chitosan membranes on scarring process following lumbar surgery :post-laminectomy experimental model
author Carvalho, Miguel Trigo de
author_facet Carvalho, Miguel Trigo de
author_role author
dc.contributor.author.fl_str_mv Carvalho, Miguel Trigo de
dc.subject.por.fl_str_mv Vértebras lombares - cirurgia
Quitosano
Laminectomia
Modelos animais de doenças
Coelhos
topic Vértebras lombares - cirurgia
Quitosano
Laminectomia
Modelos animais de doenças
Coelhos
description Dissertação de mestrado em Patologia Experimental, apresentada à Faculdade de Medicina da Universidade de Coimbra
publishDate 2012
dc.date.none.fl_str_mv 2012
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/masterThesis
format masterThesis
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10316/31364
http://hdl.handle.net/10316/31364
url http://hdl.handle.net/10316/31364
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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