Ligand-Targeted Delivery of Photosensitizers for Cancer Treatment
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10316/106489 https://doi.org/10.3390/molecules25225317 |
Resumo: | Photodynamic therapy (PDT) is a promising cancer treatment which involves a photosensitizer (PS), light at a specific wavelength for PS activation and oxygen, which combine to elicit cell death. While the illumination required to activate a PS imparts a certain amount of selectivity to PDT treatments, poor tumor accumulation and cell internalization are still inherent properties of most intravenously administered PSs. As a result, common consequences of PDT include skin photosensitivity. To overcome the mentioned issues, PSs may be tailored to specifically target overexpressed biomarkers of tumors. This active targeting can be achieved by direct conjugation of the PS to a ligand with enhanced affinity for a target overexpressed on cancer cells and/or other cells of the tumor microenvironment. Alternatively, PSs may be incorporated into ligand-targeted nanocarriers, which may also encompass multi-functionalities, including diagnosis and therapy. In this review, we highlight the major advances in active targeting of PSs, either by means of ligand-derived bioconjugates or by exploiting ligand-targeting nanocarriers. |
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Ligand-Targeted Delivery of Photosensitizers for Cancer Treatmentphotodynamic therapycancerdrug deliveryactive targetingnanocarriersHumansLigandsNanoparticlesNeoplasmsPeptidesPhotosensitizing AgentsDrug Delivery SystemsPhotodynamic therapy (PDT) is a promising cancer treatment which involves a photosensitizer (PS), light at a specific wavelength for PS activation and oxygen, which combine to elicit cell death. While the illumination required to activate a PS imparts a certain amount of selectivity to PDT treatments, poor tumor accumulation and cell internalization are still inherent properties of most intravenously administered PSs. As a result, common consequences of PDT include skin photosensitivity. To overcome the mentioned issues, PSs may be tailored to specifically target overexpressed biomarkers of tumors. This active targeting can be achieved by direct conjugation of the PS to a ligand with enhanced affinity for a target overexpressed on cancer cells and/or other cells of the tumor microenvironment. Alternatively, PSs may be incorporated into ligand-targeted nanocarriers, which may also encompass multi-functionalities, including diagnosis and therapy. In this review, we highlight the major advances in active targeting of PSs, either by means of ligand-derived bioconjugates or by exploiting ligand-targeting nanocarriers.MDPI2020-11-14info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10316/106489http://hdl.handle.net/10316/106489https://doi.org/10.3390/molecules25225317eng1420-3049Gierlich, PiotrMata, Ana I.Donohoe, ClaireBrito, Rui M. M.Senge, Mathias O.Silva, Lígia C. Gomes dainfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-04-05T20:44:17Zoai:estudogeral.uc.pt:10316/106489Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:22:56.294574Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Ligand-Targeted Delivery of Photosensitizers for Cancer Treatment |
title |
Ligand-Targeted Delivery of Photosensitizers for Cancer Treatment |
spellingShingle |
Ligand-Targeted Delivery of Photosensitizers for Cancer Treatment Gierlich, Piotr photodynamic therapy cancer drug delivery active targeting nanocarriers Humans Ligands Nanoparticles Neoplasms Peptides Photosensitizing Agents Drug Delivery Systems |
title_short |
Ligand-Targeted Delivery of Photosensitizers for Cancer Treatment |
title_full |
Ligand-Targeted Delivery of Photosensitizers for Cancer Treatment |
title_fullStr |
Ligand-Targeted Delivery of Photosensitizers for Cancer Treatment |
title_full_unstemmed |
Ligand-Targeted Delivery of Photosensitizers for Cancer Treatment |
title_sort |
Ligand-Targeted Delivery of Photosensitizers for Cancer Treatment |
author |
Gierlich, Piotr |
author_facet |
Gierlich, Piotr Mata, Ana I. Donohoe, Claire Brito, Rui M. M. Senge, Mathias O. Silva, Lígia C. Gomes da |
author_role |
author |
author2 |
Mata, Ana I. Donohoe, Claire Brito, Rui M. M. Senge, Mathias O. Silva, Lígia C. Gomes da |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Gierlich, Piotr Mata, Ana I. Donohoe, Claire Brito, Rui M. M. Senge, Mathias O. Silva, Lígia C. Gomes da |
dc.subject.por.fl_str_mv |
photodynamic therapy cancer drug delivery active targeting nanocarriers Humans Ligands Nanoparticles Neoplasms Peptides Photosensitizing Agents Drug Delivery Systems |
topic |
photodynamic therapy cancer drug delivery active targeting nanocarriers Humans Ligands Nanoparticles Neoplasms Peptides Photosensitizing Agents Drug Delivery Systems |
description |
Photodynamic therapy (PDT) is a promising cancer treatment which involves a photosensitizer (PS), light at a specific wavelength for PS activation and oxygen, which combine to elicit cell death. While the illumination required to activate a PS imparts a certain amount of selectivity to PDT treatments, poor tumor accumulation and cell internalization are still inherent properties of most intravenously administered PSs. As a result, common consequences of PDT include skin photosensitivity. To overcome the mentioned issues, PSs may be tailored to specifically target overexpressed biomarkers of tumors. This active targeting can be achieved by direct conjugation of the PS to a ligand with enhanced affinity for a target overexpressed on cancer cells and/or other cells of the tumor microenvironment. Alternatively, PSs may be incorporated into ligand-targeted nanocarriers, which may also encompass multi-functionalities, including diagnosis and therapy. In this review, we highlight the major advances in active targeting of PSs, either by means of ligand-derived bioconjugates or by exploiting ligand-targeting nanocarriers. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-11-14 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10316/106489 http://hdl.handle.net/10316/106489 https://doi.org/10.3390/molecules25225317 |
url |
http://hdl.handle.net/10316/106489 https://doi.org/10.3390/molecules25225317 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
1420-3049 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
MDPI |
publisher.none.fl_str_mv |
MDPI |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
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RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799134117325963264 |