On the contribution of Angola to the initial spread of HIV-1

Detalhes bibliográficos
Autor(a) principal: Pineda-Peña, Andrea-Clemencia
Data de Publicação: 2016
Outros Autores: Varanda, Jorge, Sousa, João Dinis, Theys, Kristof, Bártolo, Inês, Leitner, Thomas, Taveira, Nuno, Vandamme, Anne-Mieke, Abecasis, Ana B.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.26/30462
Resumo: Licenced under CC-BY-NC-ND
id RCAP_f6c64282b85377c5f84929d379cbba38
oai_identifier_str oai:comum.rcaap.pt:10400.26/30462
network_acronym_str RCAP
network_name_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository_id_str 7160
spelling On the contribution of Angola to the initial spread of HIV-1AngolaGroup MHIV-1OriginPhylogeographyLicenced under CC-BY-NC-NDAngola borders and has long-term links with Democratic Republic of Congo (DRC) as well as high levels of Human Immunodeficiency Virus (HIV) genetic diversity, indicating a potential role in the initial spread of the HIV-1 pandemic. Herein, we analyze 564 C2V3 and 354 pol publicly available sequences from DRC, Republic of Congo (RC) and Angola to better understand the initial spread of the virus in this region. Phylogeographic analyses were performed with the BEAST software. While our results pinpoint the origin of the pandemic to Kinshasa (DRC) around 1906, the introduction of HIV-1 to Angola could have occurred early between the 1910s and 1940s. Furthermore, most of the HIV-1 migrations out of Kinshasa were directed not only to Lubumbashi and Mbuji-Mayi (DRC), but also to Luanda and Brazzaville. Kinshasa census records corroborate these findings, indicating that the early exportation of the virus to Angola might be related to the high number of Angolans in Kinshasa at that time, originated mostly from the North of Angola. In summary, our results place Angola at the epicenter of the early HIV dissemination, together with DRC and RC.ElsevierRepositório ComumPineda-Peña, Andrea-ClemenciaVaranda, JorgeSousa, João DinisTheys, KristofBártolo, InêsLeitner, ThomasTaveira, NunoVandamme, Anne-MiekeAbecasis, Ana B.2019-12-12T12:56:51Z2016-12-01T00:00:00Z2016-12-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.26/30462engInfect Genet Evol. 2016 Dec;46:219-222. doi: 10.1016/j.meegid.2016.08.009.1567-134810.1016/j.meegid.2016.08.009info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-10-06T14:53:51Zoai:comum.rcaap.pt:10400.26/30462Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T15:09:37.780319Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv On the contribution of Angola to the initial spread of HIV-1
title On the contribution of Angola to the initial spread of HIV-1
spellingShingle On the contribution of Angola to the initial spread of HIV-1
Pineda-Peña, Andrea-Clemencia
Angola
Group M
HIV-1
Origin
Phylogeography
title_short On the contribution of Angola to the initial spread of HIV-1
title_full On the contribution of Angola to the initial spread of HIV-1
title_fullStr On the contribution of Angola to the initial spread of HIV-1
title_full_unstemmed On the contribution of Angola to the initial spread of HIV-1
title_sort On the contribution of Angola to the initial spread of HIV-1
author Pineda-Peña, Andrea-Clemencia
author_facet Pineda-Peña, Andrea-Clemencia
Varanda, Jorge
Sousa, João Dinis
Theys, Kristof
Bártolo, Inês
Leitner, Thomas
Taveira, Nuno
Vandamme, Anne-Mieke
Abecasis, Ana B.
author_role author
author2 Varanda, Jorge
Sousa, João Dinis
Theys, Kristof
Bártolo, Inês
Leitner, Thomas
Taveira, Nuno
Vandamme, Anne-Mieke
Abecasis, Ana B.
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório Comum
dc.contributor.author.fl_str_mv Pineda-Peña, Andrea-Clemencia
Varanda, Jorge
Sousa, João Dinis
Theys, Kristof
Bártolo, Inês
Leitner, Thomas
Taveira, Nuno
Vandamme, Anne-Mieke
Abecasis, Ana B.
dc.subject.por.fl_str_mv Angola
Group M
HIV-1
Origin
Phylogeography
topic Angola
Group M
HIV-1
Origin
Phylogeography
description Licenced under CC-BY-NC-ND
publishDate 2016
dc.date.none.fl_str_mv 2016-12-01T00:00:00Z
2016-12-01T00:00:00Z
2019-12-12T12:56:51Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.26/30462
url http://hdl.handle.net/10400.26/30462
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Infect Genet Evol. 2016 Dec;46:219-222. doi: 10.1016/j.meegid.2016.08.009.
1567-1348
10.1016/j.meegid.2016.08.009
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
_version_ 1799129965887750144

Registros relacionados