A rapid and low-cost nonlithographic method to fabricate biomedical microdevices for blood flow analysis
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10198/11879 |
Resumo: | Microfluidic devices are electrical/mechanical systems that offer the ability to work with minimal sample volumes, short reactions times, and have the possibility to perform massive parallel operations. An important application of microfluidics is blood rheology in microdevices, which has played a key role in recent developments of lab-on-chip devices for blood sampling and analysis. The most popular and traditional method to fabricate these types of devices is the polydimethylsiloxane (PDMS) soft lithography technique, which requires molds, usually produced by photolithography. Although the research results are extremely encouraging, the high costs and time involved in the production of molds by photolithography is currently slowing down the development cycle of these types of devices. Here we present a simple, rapid, and low-cost nonlithographic technique to create microfluidic systems for biomedical applications. The results demonstrate the ability of the proposed method to perform cell free layer (CFL) measurements and the formation of microbubbles in continuous blood flow. |
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A rapid and low-cost nonlithographic method to fabricate biomedical microdevices for blood flow analysisLow cost biochipsNonlithographic techniqueXurographyBlood flowBifurcationsMicrobubblesMicrofluidic devices are electrical/mechanical systems that offer the ability to work with minimal sample volumes, short reactions times, and have the possibility to perform massive parallel operations. An important application of microfluidics is blood rheology in microdevices, which has played a key role in recent developments of lab-on-chip devices for blood sampling and analysis. The most popular and traditional method to fabricate these types of devices is the polydimethylsiloxane (PDMS) soft lithography technique, which requires molds, usually produced by photolithography. Although the research results are extremely encouraging, the high costs and time involved in the production of molds by photolithography is currently slowing down the development cycle of these types of devices. Here we present a simple, rapid, and low-cost nonlithographic technique to create microfluidic systems for biomedical applications. The results demonstrate the ability of the proposed method to perform cell free layer (CFL) measurements and the formation of microbubbles in continuous blood flow.PTDC/SAU-BEB/105650/2008, PTDC/SAU-ENB/116929/2010, EXPL/EMS-SIS/2215/2013 and scholarship SFRH/BD/89077/2012 and SFRH/BD/97658/2013 from FCT (Science and Technology Foundation), COMPETE, QREN and European Union (FEDER).MDPIBiblioteca Digital do IPBPinto, ElmanoFaustino, VeraRodrigues, Raquel OliveiraPinho, DianaGarcia, ValdemarMiranda, João MárioLima, Rui A.2015-06-19T09:51:01Z20152015-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10198/11879engPinto, Elmano; Faustino, V.; Rodrigues, Raquel Oliveira; Pinho, Diana; Garcia, Valdemar; Miranda, João; Lima, R. (2015). A rapid and low-cost nonlithographic method to fabricate biomedical microdevices for blood flow analysis. Micromachines. ISSN 2072-666X. 6, p. 121-1352072-666X10.3390/mi6010121info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-21T10:27:39Zoai:bibliotecadigital.ipb.pt:10198/11879Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T23:02:14.499501Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
A rapid and low-cost nonlithographic method to fabricate biomedical microdevices for blood flow analysis |
title |
A rapid and low-cost nonlithographic method to fabricate biomedical microdevices for blood flow analysis |
spellingShingle |
A rapid and low-cost nonlithographic method to fabricate biomedical microdevices for blood flow analysis Pinto, Elmano Low cost biochips Nonlithographic technique Xurography Blood flow Bifurcations Microbubbles |
title_short |
A rapid and low-cost nonlithographic method to fabricate biomedical microdevices for blood flow analysis |
title_full |
A rapid and low-cost nonlithographic method to fabricate biomedical microdevices for blood flow analysis |
title_fullStr |
A rapid and low-cost nonlithographic method to fabricate biomedical microdevices for blood flow analysis |
title_full_unstemmed |
A rapid and low-cost nonlithographic method to fabricate biomedical microdevices for blood flow analysis |
title_sort |
A rapid and low-cost nonlithographic method to fabricate biomedical microdevices for blood flow analysis |
author |
Pinto, Elmano |
author_facet |
Pinto, Elmano Faustino, Vera Rodrigues, Raquel Oliveira Pinho, Diana Garcia, Valdemar Miranda, João Mário Lima, Rui A. |
author_role |
author |
author2 |
Faustino, Vera Rodrigues, Raquel Oliveira Pinho, Diana Garcia, Valdemar Miranda, João Mário Lima, Rui A. |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Biblioteca Digital do IPB |
dc.contributor.author.fl_str_mv |
Pinto, Elmano Faustino, Vera Rodrigues, Raquel Oliveira Pinho, Diana Garcia, Valdemar Miranda, João Mário Lima, Rui A. |
dc.subject.por.fl_str_mv |
Low cost biochips Nonlithographic technique Xurography Blood flow Bifurcations Microbubbles |
topic |
Low cost biochips Nonlithographic technique Xurography Blood flow Bifurcations Microbubbles |
description |
Microfluidic devices are electrical/mechanical systems that offer the ability to work with minimal sample volumes, short reactions times, and have the possibility to perform massive parallel operations. An important application of microfluidics is blood rheology in microdevices, which has played a key role in recent developments of lab-on-chip devices for blood sampling and analysis. The most popular and traditional method to fabricate these types of devices is the polydimethylsiloxane (PDMS) soft lithography technique, which requires molds, usually produced by photolithography. Although the research results are extremely encouraging, the high costs and time involved in the production of molds by photolithography is currently slowing down the development cycle of these types of devices. Here we present a simple, rapid, and low-cost nonlithographic technique to create microfluidic systems for biomedical applications. The results demonstrate the ability of the proposed method to perform cell free layer (CFL) measurements and the formation of microbubbles in continuous blood flow. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-06-19T09:51:01Z 2015 2015-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10198/11879 |
url |
http://hdl.handle.net/10198/11879 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Pinto, Elmano; Faustino, V.; Rodrigues, Raquel Oliveira; Pinho, Diana; Garcia, Valdemar; Miranda, João; Lima, R. (2015). A rapid and low-cost nonlithographic method to fabricate biomedical microdevices for blood flow analysis. Micromachines. ISSN 2072-666X. 6, p. 121-135 2072-666X 10.3390/mi6010121 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
MDPI |
publisher.none.fl_str_mv |
MDPI |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
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1799135260425846784 |