The antihypertensive and antihypertrophic effect of lycopene is not affected by and is independent of age

Detalhes bibliográficos
Autor(a) principal: Santos, Pedro Miguel Ferreira
Data de Publicação: 2021
Outros Autores: Carrón, Rosalía, Montero, M. José, Sevilla, M. Ángeles
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/73809
Resumo: Hypertension of SHR appears at an early age and progressively increases. This study aimed to evaluate the effect of lycopene in SHR with mild hypertension (young rats) or with high level of hypertension (adult rats). Four-weeks treatment with 10 mg/kg/day of lycopene progressively decreased blood pressure in young (from 144 ± 2 to 119 ± 3 mmHg) and adult (from 177 ± 5 to 159 ± 7 mmHg) SHR. Heart and renal hypertrophy and fibrosis were increased in adult compared to young SHR and lycopene, regardless of the age of the rats, improved the injury in both organs. Although aging induced morphological and functional alterations in the aorta, the treatment was only effective in preventing the former. Lycopene helped to improve all the parameters linked to oxidative stress determined in this study. In conclusion, lycopene treatment improved the age-associated harmful changes in hypertension, cardiovascular and renal remodelling, and indicators of oxidant-antioxidant systems in both young and adult SHR.
id RCAP_f942a8587de46702913cd0d26fdc80e4
oai_identifier_str oai:repositorium.sdum.uminho.pt:1822/73809
network_acronym_str RCAP
network_name_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository_id_str 7160
spelling The antihypertensive and antihypertrophic effect of lycopene is not affected by and is independent of ageLycopeneAgingSHRCardiovascularOxidative stressScience & TechnologyHypertension of SHR appears at an early age and progressively increases. This study aimed to evaluate the effect of lycopene in SHR with mild hypertension (young rats) or with high level of hypertension (adult rats). Four-weeks treatment with 10 mg/kg/day of lycopene progressively decreased blood pressure in young (from 144 ± 2 to 119 ± 3 mmHg) and adult (from 177 ± 5 to 159 ± 7 mmHg) SHR. Heart and renal hypertrophy and fibrosis were increased in adult compared to young SHR and lycopene, regardless of the age of the rats, improved the injury in both organs. Although aging induced morphological and functional alterations in the aorta, the treatment was only effective in preventing the former. Lycopene helped to improve all the parameters linked to oxidative stress determined in this study. In conclusion, lycopene treatment improved the age-associated harmful changes in hypertension, cardiovascular and renal remodelling, and indicators of oxidant-antioxidant systems in both young and adult SHR.This work was financed by the University of Salamanca (Spain). Pedro Ferreira Santos was the recipient of a fellowship funded by a project Art.83/LOU of University of Salamanca. Lycopene was kindly supplied by DSM NUTRITIONAL PRODUCTSinfo:eu-repo/semantics/publishedVersionElsevierUniversidade do MinhoSantos, Pedro Miguel FerreiraCarrón, RosalíaMontero, M. JoséSevilla, M. Ángeles2021-082021-08-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/73809engFerreira-Santos, P.; Carrón, Rosalía; Montero, M. José; Sevilla, M. Ángeles, The antihypertensive and antihypertrophic effect of lycopene is not affected by and is independent of age. Journal of Functional Foods, 85(104656), 20211756-464610.1016/j.jff.2021.104656https://www.sciencedirect.com/science/article/pii/S1756464621003054info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:25:38Zoai:repositorium.sdum.uminho.pt:1822/73809Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:19:56.735248Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv The antihypertensive and antihypertrophic effect of lycopene is not affected by and is independent of age
title The antihypertensive and antihypertrophic effect of lycopene is not affected by and is independent of age
spellingShingle The antihypertensive and antihypertrophic effect of lycopene is not affected by and is independent of age
Santos, Pedro Miguel Ferreira
Lycopene
Aging
SHR
Cardiovascular
Oxidative stress
Science & Technology
title_short The antihypertensive and antihypertrophic effect of lycopene is not affected by and is independent of age
title_full The antihypertensive and antihypertrophic effect of lycopene is not affected by and is independent of age
title_fullStr The antihypertensive and antihypertrophic effect of lycopene is not affected by and is independent of age
title_full_unstemmed The antihypertensive and antihypertrophic effect of lycopene is not affected by and is independent of age
title_sort The antihypertensive and antihypertrophic effect of lycopene is not affected by and is independent of age
author Santos, Pedro Miguel Ferreira
author_facet Santos, Pedro Miguel Ferreira
Carrón, Rosalía
Montero, M. José
Sevilla, M. Ángeles
author_role author
author2 Carrón, Rosalía
Montero, M. José
Sevilla, M. Ángeles
author2_role author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Santos, Pedro Miguel Ferreira
Carrón, Rosalía
Montero, M. José
Sevilla, M. Ángeles
dc.subject.por.fl_str_mv Lycopene
Aging
SHR
Cardiovascular
Oxidative stress
Science & Technology
topic Lycopene
Aging
SHR
Cardiovascular
Oxidative stress
Science & Technology
description Hypertension of SHR appears at an early age and progressively increases. This study aimed to evaluate the effect of lycopene in SHR with mild hypertension (young rats) or with high level of hypertension (adult rats). Four-weeks treatment with 10 mg/kg/day of lycopene progressively decreased blood pressure in young (from 144 ± 2 to 119 ± 3 mmHg) and adult (from 177 ± 5 to 159 ± 7 mmHg) SHR. Heart and renal hypertrophy and fibrosis were increased in adult compared to young SHR and lycopene, regardless of the age of the rats, improved the injury in both organs. Although aging induced morphological and functional alterations in the aorta, the treatment was only effective in preventing the former. Lycopene helped to improve all the parameters linked to oxidative stress determined in this study. In conclusion, lycopene treatment improved the age-associated harmful changes in hypertension, cardiovascular and renal remodelling, and indicators of oxidant-antioxidant systems in both young and adult SHR.
publishDate 2021
dc.date.none.fl_str_mv 2021-08
2021-08-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/73809
url http://hdl.handle.net/1822/73809
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Ferreira-Santos, P.; Carrón, Rosalía; Montero, M. José; Sevilla, M. Ángeles, The antihypertensive and antihypertrophic effect of lycopene is not affected by and is independent of age. Journal of Functional Foods, 85(104656), 2021
1756-4646
10.1016/j.jff.2021.104656
https://www.sciencedirect.com/science/article/pii/S1756464621003054
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
_version_ 1799132660500529152

Registros relacionados