The antihypertensive and antihypertrophic effect of lycopene is not affected by and is independent of age
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/1822/73809 |
Resumo: | Hypertension of SHR appears at an early age and progressively increases. This study aimed to evaluate the effect of lycopene in SHR with mild hypertension (young rats) or with high level of hypertension (adult rats). Four-weeks treatment with 10 mg/kg/day of lycopene progressively decreased blood pressure in young (from 144 ± 2 to 119 ± 3 mmHg) and adult (from 177 ± 5 to 159 ± 7 mmHg) SHR. Heart and renal hypertrophy and fibrosis were increased in adult compared to young SHR and lycopene, regardless of the age of the rats, improved the injury in both organs. Although aging induced morphological and functional alterations in the aorta, the treatment was only effective in preventing the former. Lycopene helped to improve all the parameters linked to oxidative stress determined in this study. In conclusion, lycopene treatment improved the age-associated harmful changes in hypertension, cardiovascular and renal remodelling, and indicators of oxidant-antioxidant systems in both young and adult SHR. |
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The antihypertensive and antihypertrophic effect of lycopene is not affected by and is independent of ageLycopeneAgingSHRCardiovascularOxidative stressScience & TechnologyHypertension of SHR appears at an early age and progressively increases. This study aimed to evaluate the effect of lycopene in SHR with mild hypertension (young rats) or with high level of hypertension (adult rats). Four-weeks treatment with 10 mg/kg/day of lycopene progressively decreased blood pressure in young (from 144 ± 2 to 119 ± 3 mmHg) and adult (from 177 ± 5 to 159 ± 7 mmHg) SHR. Heart and renal hypertrophy and fibrosis were increased in adult compared to young SHR and lycopene, regardless of the age of the rats, improved the injury in both organs. Although aging induced morphological and functional alterations in the aorta, the treatment was only effective in preventing the former. Lycopene helped to improve all the parameters linked to oxidative stress determined in this study. In conclusion, lycopene treatment improved the age-associated harmful changes in hypertension, cardiovascular and renal remodelling, and indicators of oxidant-antioxidant systems in both young and adult SHR.This work was financed by the University of Salamanca (Spain). Pedro Ferreira Santos was the recipient of a fellowship funded by a project Art.83/LOU of University of Salamanca. Lycopene was kindly supplied by DSM NUTRITIONAL PRODUCTSinfo:eu-repo/semantics/publishedVersionElsevierUniversidade do MinhoSantos, Pedro Miguel FerreiraCarrón, RosalíaMontero, M. JoséSevilla, M. Ángeles2021-082021-08-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/73809engFerreira-Santos, P.; Carrón, Rosalía; Montero, M. José; Sevilla, M. Ángeles, The antihypertensive and antihypertrophic effect of lycopene is not affected by and is independent of age. Journal of Functional Foods, 85(104656), 20211756-464610.1016/j.jff.2021.104656https://www.sciencedirect.com/science/article/pii/S1756464621003054info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:25:38Zoai:repositorium.sdum.uminho.pt:1822/73809Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:19:56.735248Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
The antihypertensive and antihypertrophic effect of lycopene is not affected by and is independent of age |
title |
The antihypertensive and antihypertrophic effect of lycopene is not affected by and is independent of age |
spellingShingle |
The antihypertensive and antihypertrophic effect of lycopene is not affected by and is independent of age Santos, Pedro Miguel Ferreira Lycopene Aging SHR Cardiovascular Oxidative stress Science & Technology |
title_short |
The antihypertensive and antihypertrophic effect of lycopene is not affected by and is independent of age |
title_full |
The antihypertensive and antihypertrophic effect of lycopene is not affected by and is independent of age |
title_fullStr |
The antihypertensive and antihypertrophic effect of lycopene is not affected by and is independent of age |
title_full_unstemmed |
The antihypertensive and antihypertrophic effect of lycopene is not affected by and is independent of age |
title_sort |
The antihypertensive and antihypertrophic effect of lycopene is not affected by and is independent of age |
author |
Santos, Pedro Miguel Ferreira |
author_facet |
Santos, Pedro Miguel Ferreira Carrón, Rosalía Montero, M. José Sevilla, M. Ángeles |
author_role |
author |
author2 |
Carrón, Rosalía Montero, M. José Sevilla, M. Ángeles |
author2_role |
author author author |
dc.contributor.none.fl_str_mv |
Universidade do Minho |
dc.contributor.author.fl_str_mv |
Santos, Pedro Miguel Ferreira Carrón, Rosalía Montero, M. José Sevilla, M. Ángeles |
dc.subject.por.fl_str_mv |
Lycopene Aging SHR Cardiovascular Oxidative stress Science & Technology |
topic |
Lycopene Aging SHR Cardiovascular Oxidative stress Science & Technology |
description |
Hypertension of SHR appears at an early age and progressively increases. This study aimed to evaluate the effect of lycopene in SHR with mild hypertension (young rats) or with high level of hypertension (adult rats). Four-weeks treatment with 10 mg/kg/day of lycopene progressively decreased blood pressure in young (from 144 ± 2 to 119 ± 3 mmHg) and adult (from 177 ± 5 to 159 ± 7 mmHg) SHR. Heart and renal hypertrophy and fibrosis were increased in adult compared to young SHR and lycopene, regardless of the age of the rats, improved the injury in both organs. Although aging induced morphological and functional alterations in the aorta, the treatment was only effective in preventing the former. Lycopene helped to improve all the parameters linked to oxidative stress determined in this study. In conclusion, lycopene treatment improved the age-associated harmful changes in hypertension, cardiovascular and renal remodelling, and indicators of oxidant-antioxidant systems in both young and adult SHR. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-08 2021-08-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1822/73809 |
url |
http://hdl.handle.net/1822/73809 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Ferreira-Santos, P.; Carrón, Rosalía; Montero, M. José; Sevilla, M. Ángeles, The antihypertensive and antihypertrophic effect of lycopene is not affected by and is independent of age. Journal of Functional Foods, 85(104656), 2021 1756-4646 10.1016/j.jff.2021.104656 https://www.sciencedirect.com/science/article/pii/S1756464621003054 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier |
publisher.none.fl_str_mv |
Elsevier |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
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1799132660500529152 |