Development of magnetically active scaffolds for bone regeneration
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/1822/57362 |
Resumo: | This work reports on the synthesis, with the thermally induced phase separation (TIPS) technique, of poly (L-lactide) (PLLA) scaffolds containing Fe-doped hydroxyapatite (FeHA) particles for bone regeneration. Magnetization curves and X-ray diffraction indicate two magnetic particle phases: FeHA and magnetite Fe3O4. Magnetic nanoparticles (MNPs) are approximately 30 ± 5 nm in width and 125 ± 25 nm in length, and show typical ferromagnetic properties, including coercivity and rapid saturation magnetization. Scanning electron microscopy (SEM) images of the magnetic scaffolds reveal their complex morphology changes with MNP concentration. Similarly, at compositions of approximately 20% MNPs, the phase separation changes, passing from solid–liquid to liquid–liquid as revealed by the hill-like structures, with low peaks that give the walls in the SEM images a surface pattern of micro-ruggedness typical of nucleation mechanisms and growth. In vitro degradation experiments, carried out for more than 28 weeks, demonstrated that the MNPs delay the scaffold degradation process. Cytotoxicity is appreciated for FeHA content above 20%. |
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Development of magnetically active scaffolds for bone regenerationCytotoxicityFe-doped hydroxyapatiteMagnetismPoly (L-lactide)ScaffoldsScience & TechnologyThis work reports on the synthesis, with the thermally induced phase separation (TIPS) technique, of poly (L-lactide) (PLLA) scaffolds containing Fe-doped hydroxyapatite (FeHA) particles for bone regeneration. Magnetization curves and X-ray diffraction indicate two magnetic particle phases: FeHA and magnetite Fe3O4. Magnetic nanoparticles (MNPs) are approximately 30 ± 5 nm in width and 125 ± 25 nm in length, and show typical ferromagnetic properties, including coercivity and rapid saturation magnetization. Scanning electron microscopy (SEM) images of the magnetic scaffolds reveal their complex morphology changes with MNP concentration. Similarly, at compositions of approximately 20% MNPs, the phase separation changes, passing from solid–liquid to liquid–liquid as revealed by the hill-like structures, with low peaks that give the walls in the SEM images a surface pattern of micro-ruggedness typical of nucleation mechanisms and growth. In vitro degradation experiments, carried out for more than 28 weeks, demonstrated that the MNPs delay the scaffold degradation process. Cytotoxicity is appreciated for FeHA content above 20%.This work was supported by the University of The Basque Center and the Portuguese Foundation for Science and Technology (FCT) under the framework Strategic Funding UID/FIS/04650/ UID/BIA/04050/2013, and UID/BIO/04469. S.R. would like to the FCT for the SFRH/BD/111478/2015 grant. The authors acknowledge funding by the Spanish Ministry of Economy and Competitiveness (MINECO) under the project MAT2016-76039-C4-3-R (AEI/FEDER, UE)info:eu-repo/semantics/publishedVersionMDPI AGUniversidade do MinhoDíaz, E.Valle, M. B.Ribeiro, S.Lanceros-Méndez, S.Barandiarán, J. M.20182018-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/57362engDíaz, E.; Valle, M.B.; Ribeiro, S.; Lanceros-Mendez, S.; Barandiarán, J.M. Development of Magnetically Active Scaffolds for Bone Regeneration. Nanomaterials 2018, 8, 678.2079-499110.3390/nano8090678info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:51:35Zoai:repositorium.sdum.uminho.pt:1822/57362Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:50:31.205057Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Development of magnetically active scaffolds for bone regeneration |
title |
Development of magnetically active scaffolds for bone regeneration |
spellingShingle |
Development of magnetically active scaffolds for bone regeneration Díaz, E. Cytotoxicity Fe-doped hydroxyapatite Magnetism Poly (L-lactide) Scaffolds Science & Technology |
title_short |
Development of magnetically active scaffolds for bone regeneration |
title_full |
Development of magnetically active scaffolds for bone regeneration |
title_fullStr |
Development of magnetically active scaffolds for bone regeneration |
title_full_unstemmed |
Development of magnetically active scaffolds for bone regeneration |
title_sort |
Development of magnetically active scaffolds for bone regeneration |
author |
Díaz, E. |
author_facet |
Díaz, E. Valle, M. B. Ribeiro, S. Lanceros-Méndez, S. Barandiarán, J. M. |
author_role |
author |
author2 |
Valle, M. B. Ribeiro, S. Lanceros-Méndez, S. Barandiarán, J. M. |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
Universidade do Minho |
dc.contributor.author.fl_str_mv |
Díaz, E. Valle, M. B. Ribeiro, S. Lanceros-Méndez, S. Barandiarán, J. M. |
dc.subject.por.fl_str_mv |
Cytotoxicity Fe-doped hydroxyapatite Magnetism Poly (L-lactide) Scaffolds Science & Technology |
topic |
Cytotoxicity Fe-doped hydroxyapatite Magnetism Poly (L-lactide) Scaffolds Science & Technology |
description |
This work reports on the synthesis, with the thermally induced phase separation (TIPS) technique, of poly (L-lactide) (PLLA) scaffolds containing Fe-doped hydroxyapatite (FeHA) particles for bone regeneration. Magnetization curves and X-ray diffraction indicate two magnetic particle phases: FeHA and magnetite Fe3O4. Magnetic nanoparticles (MNPs) are approximately 30 ± 5 nm in width and 125 ± 25 nm in length, and show typical ferromagnetic properties, including coercivity and rapid saturation magnetization. Scanning electron microscopy (SEM) images of the magnetic scaffolds reveal their complex morphology changes with MNP concentration. Similarly, at compositions of approximately 20% MNPs, the phase separation changes, passing from solid–liquid to liquid–liquid as revealed by the hill-like structures, with low peaks that give the walls in the SEM images a surface pattern of micro-ruggedness typical of nucleation mechanisms and growth. In vitro degradation experiments, carried out for more than 28 weeks, demonstrated that the MNPs delay the scaffold degradation process. Cytotoxicity is appreciated for FeHA content above 20%. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018 2018-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1822/57362 |
url |
http://hdl.handle.net/1822/57362 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Díaz, E.; Valle, M.B.; Ribeiro, S.; Lanceros-Mendez, S.; Barandiarán, J.M. Development of Magnetically Active Scaffolds for Bone Regeneration. Nanomaterials 2018, 8, 678. 2079-4991 10.3390/nano8090678 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
MDPI AG |
publisher.none.fl_str_mv |
MDPI AG |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
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1799133090776350720 |