Amphiphilic modified galactomannan as a novel potential carrier for hydrophobic compounds
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | https://hdl.handle.net/1822/59823 |
Resumo: | The present work aims at developing and characterizing a modified galactomannan for the production of nano-sized micelles through the solvent diffusion method and its evaluation as a new carrier for hydrophobic compounds. Guar gum galactomannan was acetylated and a new polymer with different degrees of acetylation was obtained. The acetylation and substitution degree of the polymer was determined and characterized by means of Fourier transform infrared spectroscopy and thermogravimetric analysis. Galactomannan acetate (GA) was evaluated for development of micelles through the solvent diffusion method. Critical micellar concentration (CMC) was evaluated through dynamic light scattering where the effect of a wide range of GA concentrations in the micelle formation was studied. Results showed that CMC is around 0.2 mg mL-1 and an increase of GA concentration leads to the formation of monodisperse micelles with low values of polydispersity. The influence of the degree of acetylation was evaluated in terms of size average, polydispersity (PdI) and zeta potential. Transmission electron microscopy was used to evaluate micelles morphology. It was shown that GA can be used to form micelles for the encapsulation of curcumin (used as model compound) with an encapsulation efficiency higher than 99 % and a loading capacity ranging from 5.5 to 7.7 %. Results showed that the degree of acetylation can be used to control particle size: micelles produced from GA with the lowest degree of acetylation have a diameter which is around 25 % smaller than that of micelles produced from GA with the highest degree of acetylation. This study provides information concerning the preparation of polymeric micelles based on a modified natural galactomannan for application in the food and pharmaceutical industry. To our knowledge, it is the first work dealing with galactomannans modification. |
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Amphiphilic modified galactomannan as a novel potential carrier for hydrophobic compoundsCyamopsis tetragonoloboguar gumself-assemblynanomicellesnanoencapsulationScience & TechnologyThe present work aims at developing and characterizing a modified galactomannan for the production of nano-sized micelles through the solvent diffusion method and its evaluation as a new carrier for hydrophobic compounds. Guar gum galactomannan was acetylated and a new polymer with different degrees of acetylation was obtained. The acetylation and substitution degree of the polymer was determined and characterized by means of Fourier transform infrared spectroscopy and thermogravimetric analysis. Galactomannan acetate (GA) was evaluated for development of micelles through the solvent diffusion method. Critical micellar concentration (CMC) was evaluated through dynamic light scattering where the effect of a wide range of GA concentrations in the micelle formation was studied. Results showed that CMC is around 0.2 mg mL-1 and an increase of GA concentration leads to the formation of monodisperse micelles with low values of polydispersity. The influence of the degree of acetylation was evaluated in terms of size average, polydispersity (PdI) and zeta potential. Transmission electron microscopy was used to evaluate micelles morphology. It was shown that GA can be used to form micelles for the encapsulation of curcumin (used as model compound) with an encapsulation efficiency higher than 99 % and a loading capacity ranging from 5.5 to 7.7 %. Results showed that the degree of acetylation can be used to control particle size: micelles produced from GA with the lowest degree of acetylation have a diameter which is around 25 % smaller than that of micelles produced from GA with the highest degree of acetylation. This study provides information concerning the preparation of polymeric micelles based on a modified natural galactomannan for application in the food and pharmaceutical industry. To our knowledge, it is the first work dealing with galactomannans modification.AP is recipient of a fellowship (SFRH/BPD/101181/2014), supported by Fundação para a Ciência e Tecnologia (FCT, Portugal). This work was supported by the Portuguese Foundation for Science and Technology (FCT) under the scope of the strategic funding of UID/BIO/04469/2013 unit and COMPETE 2020 (POCI-01-0145-FEDER-006684) and by BioTecNorte operation (NORTE-01-0145-FEDER-000004) funded by the European Regional Development Fund under the scope of Norte2020–Programa Operacional Regional do Norte. The authors would like to acknowledge to Rui Fernandes from IBMC, University of Porto for assistance in taking the TEM pictures.info:eu-repo/semantics/publishedVersionFrontiers MediaUniversidade do MinhoCerqueira, Miguel A.Pinheiro, Ana CristinaPastrana, Lorenzo M.Vicente, A. A.2019-03-262019-03-26T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/1822/59823engCerqueira, Miguel A.; Pinheiro, Ana Cristina; Pastrana, Lorenzo M.; Vicente, António A., Amphiphilic modified galactomannan as a novel potential carrier for hydrophobic compounds. Frontiers in Sustainable Food Systems, 3(17), 20192571-581X2571-581X10.3389/fsufs.2019.00017https://www.frontiersin.org/journals/sustainable-food-systems#info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-05-11T06:21:03Zoai:repositorium.sdum.uminho.pt:1822/59823Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-05-11T06:21:03Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Amphiphilic modified galactomannan as a novel potential carrier for hydrophobic compounds |
title |
Amphiphilic modified galactomannan as a novel potential carrier for hydrophobic compounds |
spellingShingle |
Amphiphilic modified galactomannan as a novel potential carrier for hydrophobic compounds Cerqueira, Miguel A. Cyamopsis tetragonolobo guar gum self-assembly nanomicelles nanoencapsulation Science & Technology |
title_short |
Amphiphilic modified galactomannan as a novel potential carrier for hydrophobic compounds |
title_full |
Amphiphilic modified galactomannan as a novel potential carrier for hydrophobic compounds |
title_fullStr |
Amphiphilic modified galactomannan as a novel potential carrier for hydrophobic compounds |
title_full_unstemmed |
Amphiphilic modified galactomannan as a novel potential carrier for hydrophobic compounds |
title_sort |
Amphiphilic modified galactomannan as a novel potential carrier for hydrophobic compounds |
author |
Cerqueira, Miguel A. |
author_facet |
Cerqueira, Miguel A. Pinheiro, Ana Cristina Pastrana, Lorenzo M. Vicente, A. A. |
author_role |
author |
author2 |
Pinheiro, Ana Cristina Pastrana, Lorenzo M. Vicente, A. A. |
author2_role |
author author author |
dc.contributor.none.fl_str_mv |
Universidade do Minho |
dc.contributor.author.fl_str_mv |
Cerqueira, Miguel A. Pinheiro, Ana Cristina Pastrana, Lorenzo M. Vicente, A. A. |
dc.subject.por.fl_str_mv |
Cyamopsis tetragonolobo guar gum self-assembly nanomicelles nanoencapsulation Science & Technology |
topic |
Cyamopsis tetragonolobo guar gum self-assembly nanomicelles nanoencapsulation Science & Technology |
description |
The present work aims at developing and characterizing a modified galactomannan for the production of nano-sized micelles through the solvent diffusion method and its evaluation as a new carrier for hydrophobic compounds. Guar gum galactomannan was acetylated and a new polymer with different degrees of acetylation was obtained. The acetylation and substitution degree of the polymer was determined and characterized by means of Fourier transform infrared spectroscopy and thermogravimetric analysis. Galactomannan acetate (GA) was evaluated for development of micelles through the solvent diffusion method. Critical micellar concentration (CMC) was evaluated through dynamic light scattering where the effect of a wide range of GA concentrations in the micelle formation was studied. Results showed that CMC is around 0.2 mg mL-1 and an increase of GA concentration leads to the formation of monodisperse micelles with low values of polydispersity. The influence of the degree of acetylation was evaluated in terms of size average, polydispersity (PdI) and zeta potential. Transmission electron microscopy was used to evaluate micelles morphology. It was shown that GA can be used to form micelles for the encapsulation of curcumin (used as model compound) with an encapsulation efficiency higher than 99 % and a loading capacity ranging from 5.5 to 7.7 %. Results showed that the degree of acetylation can be used to control particle size: micelles produced from GA with the lowest degree of acetylation have a diameter which is around 25 % smaller than that of micelles produced from GA with the highest degree of acetylation. This study provides information concerning the preparation of polymeric micelles based on a modified natural galactomannan for application in the food and pharmaceutical industry. To our knowledge, it is the first work dealing with galactomannans modification. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-03-26 2019-03-26T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://hdl.handle.net/1822/59823 |
url |
https://hdl.handle.net/1822/59823 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Cerqueira, Miguel A.; Pinheiro, Ana Cristina; Pastrana, Lorenzo M.; Vicente, António A., Amphiphilic modified galactomannan as a novel potential carrier for hydrophobic compounds. Frontiers in Sustainable Food Systems, 3(17), 2019 2571-581X 2571-581X 10.3389/fsufs.2019.00017 https://www.frontiersin.org/journals/sustainable-food-systems# |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Frontiers Media |
publisher.none.fl_str_mv |
Frontiers Media |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
mluisa.alvim@gmail.com |
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1817544942335033344 |