Cardiac Remodeling in Obesity-Resistance Model is not Related to Collagen I and III Protein Expression
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | International Journal of Cardiovascular Sciences (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S2359-56472021005010201 |
Resumo: | Abstract Background: As some individuals present resistance to obesity development, experiments have been trying to understand their susceptibility to cardiometabolic diseases. Objetive: To evaluate if the cardiac remodeling was related to collagen protein expression change. Methods: Male Wistar rats were randomized into two experimental groups: control diet (CD, n=15) or high-fat diet (HFD, n=15) for 30 weeks. Rats fed with HFD were ranked based on their adiposity indexes and classified as obese (Ob, n = 8) or obesity-resistant (ROb, n = 6). Rats that failed to present the normal characteristic of the control group while fed with CD were excluded (Control, n = 8). Nutritional profile, comorbidities (dyslipidemia, hypertension, glucose metabolism, hyperleptinemia), cardiac remodeling, and collagen protein expression were evaluated. The groups were compared by One-Way ANOVA, together the Tukey post hoc test, with p<0.05 considered significant. Results: The Ob rats presented an increased adiposity index when compared to C and ROb. Both groups Ob and ROb presented increased low-density lipoprotein (LDL), insulin, homeostatic model assessment of insulin resistance (HOMA- IR) and systolic blood pressure (SBP), and low high-density lipoprotein (HDL) levels when compared to the control group. The levels of triglycerides, non-esterified fatty acid (NEFA), and leptin were lower in ROb as compared to Ob, but higher than the control group. The Ob and ROb groups presented cardiac remodeling, evidenced by echocardiographic and post-mortem analysis. The collagen protein expression did not differ among the groups. Conclusion: The ROb animals present cardiac remodeling that is not related to collagen type I and III protein expression change. |
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International Journal of Cardiovascular Sciences (Online) |
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Cardiac Remodeling in Obesity-Resistance Model is not Related to Collagen I and III Protein ExpressionObesityAdiposityDietAbstract Background: As some individuals present resistance to obesity development, experiments have been trying to understand their susceptibility to cardiometabolic diseases. Objetive: To evaluate if the cardiac remodeling was related to collagen protein expression change. Methods: Male Wistar rats were randomized into two experimental groups: control diet (CD, n=15) or high-fat diet (HFD, n=15) for 30 weeks. Rats fed with HFD were ranked based on their adiposity indexes and classified as obese (Ob, n = 8) or obesity-resistant (ROb, n = 6). Rats that failed to present the normal characteristic of the control group while fed with CD were excluded (Control, n = 8). Nutritional profile, comorbidities (dyslipidemia, hypertension, glucose metabolism, hyperleptinemia), cardiac remodeling, and collagen protein expression were evaluated. The groups were compared by One-Way ANOVA, together the Tukey post hoc test, with p<0.05 considered significant. Results: The Ob rats presented an increased adiposity index when compared to C and ROb. Both groups Ob and ROb presented increased low-density lipoprotein (LDL), insulin, homeostatic model assessment of insulin resistance (HOMA- IR) and systolic blood pressure (SBP), and low high-density lipoprotein (HDL) levels when compared to the control group. The levels of triglycerides, non-esterified fatty acid (NEFA), and leptin were lower in ROb as compared to Ob, but higher than the control group. The Ob and ROb groups presented cardiac remodeling, evidenced by echocardiographic and post-mortem analysis. The collagen protein expression did not differ among the groups. Conclusion: The ROb animals present cardiac remodeling that is not related to collagen type I and III protein expression change.Sociedade Brasileira de Cardiologia2021-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S2359-56472021005010201International Journal of Cardiovascular Sciences n.ahead 2021reponame:International Journal of Cardiovascular Sciences (Online)instname:Sociedade Brasileira de Cardiologia (SBC)instacron:SBC10.36660/ijcs.20200058info:eu-repo/semantics/openAccessOliveira,Scarlet Marques deGarcia,Jéssica LeiteVileigas,Danielle FernandesCampos,Dijon Henrique Salomé deFrancisqueti-Ferron,Fabiane ValentiniFerron,Artur Junio TogneriSilva-Bertani,Danielle Cristina Tomaz daPadovani,Carlos RobertoCorrêa,Camila RenataCicogna,Antonio Carloseng2022-02-01T00:00:00Zoai:scielo:S2359-56472021005010201Revistahttp://publicacoes.cardiol.br/portal/ijcshttps://old.scielo.br/oai/scielo-oai.phptailanerodrigues@cardiol.br||revistaijcs@cardiol.br2359-56472359-4802opendoar:2022-02-01T00:00International Journal of Cardiovascular Sciences (Online) - Sociedade Brasileira de Cardiologia (SBC)false |
dc.title.none.fl_str_mv |
Cardiac Remodeling in Obesity-Resistance Model is not Related to Collagen I and III Protein Expression |
title |
Cardiac Remodeling in Obesity-Resistance Model is not Related to Collagen I and III Protein Expression |
spellingShingle |
Cardiac Remodeling in Obesity-Resistance Model is not Related to Collagen I and III Protein Expression Oliveira,Scarlet Marques de Obesity Adiposity Diet |
title_short |
Cardiac Remodeling in Obesity-Resistance Model is not Related to Collagen I and III Protein Expression |
title_full |
Cardiac Remodeling in Obesity-Resistance Model is not Related to Collagen I and III Protein Expression |
title_fullStr |
Cardiac Remodeling in Obesity-Resistance Model is not Related to Collagen I and III Protein Expression |
title_full_unstemmed |
Cardiac Remodeling in Obesity-Resistance Model is not Related to Collagen I and III Protein Expression |
title_sort |
Cardiac Remodeling in Obesity-Resistance Model is not Related to Collagen I and III Protein Expression |
author |
Oliveira,Scarlet Marques de |
author_facet |
Oliveira,Scarlet Marques de Garcia,Jéssica Leite Vileigas,Danielle Fernandes Campos,Dijon Henrique Salomé de Francisqueti-Ferron,Fabiane Valentini Ferron,Artur Junio Togneri Silva-Bertani,Danielle Cristina Tomaz da Padovani,Carlos Roberto Corrêa,Camila Renata Cicogna,Antonio Carlos |
author_role |
author |
author2 |
Garcia,Jéssica Leite Vileigas,Danielle Fernandes Campos,Dijon Henrique Salomé de Francisqueti-Ferron,Fabiane Valentini Ferron,Artur Junio Togneri Silva-Bertani,Danielle Cristina Tomaz da Padovani,Carlos Roberto Corrêa,Camila Renata Cicogna,Antonio Carlos |
author2_role |
author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Oliveira,Scarlet Marques de Garcia,Jéssica Leite Vileigas,Danielle Fernandes Campos,Dijon Henrique Salomé de Francisqueti-Ferron,Fabiane Valentini Ferron,Artur Junio Togneri Silva-Bertani,Danielle Cristina Tomaz da Padovani,Carlos Roberto Corrêa,Camila Renata Cicogna,Antonio Carlos |
dc.subject.por.fl_str_mv |
Obesity Adiposity Diet |
topic |
Obesity Adiposity Diet |
description |
Abstract Background: As some individuals present resistance to obesity development, experiments have been trying to understand their susceptibility to cardiometabolic diseases. Objetive: To evaluate if the cardiac remodeling was related to collagen protein expression change. Methods: Male Wistar rats were randomized into two experimental groups: control diet (CD, n=15) or high-fat diet (HFD, n=15) for 30 weeks. Rats fed with HFD were ranked based on their adiposity indexes and classified as obese (Ob, n = 8) or obesity-resistant (ROb, n = 6). Rats that failed to present the normal characteristic of the control group while fed with CD were excluded (Control, n = 8). Nutritional profile, comorbidities (dyslipidemia, hypertension, glucose metabolism, hyperleptinemia), cardiac remodeling, and collagen protein expression were evaluated. The groups were compared by One-Way ANOVA, together the Tukey post hoc test, with p<0.05 considered significant. Results: The Ob rats presented an increased adiposity index when compared to C and ROb. Both groups Ob and ROb presented increased low-density lipoprotein (LDL), insulin, homeostatic model assessment of insulin resistance (HOMA- IR) and systolic blood pressure (SBP), and low high-density lipoprotein (HDL) levels when compared to the control group. The levels of triglycerides, non-esterified fatty acid (NEFA), and leptin were lower in ROb as compared to Ob, but higher than the control group. The Ob and ROb groups presented cardiac remodeling, evidenced by echocardiographic and post-mortem analysis. The collagen protein expression did not differ among the groups. Conclusion: The ROb animals present cardiac remodeling that is not related to collagen type I and III protein expression change. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S2359-56472021005010201 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S2359-56472021005010201 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.36660/ijcs.20200058 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Cardiologia |
publisher.none.fl_str_mv |
Sociedade Brasileira de Cardiologia |
dc.source.none.fl_str_mv |
International Journal of Cardiovascular Sciences n.ahead 2021 reponame:International Journal of Cardiovascular Sciences (Online) instname:Sociedade Brasileira de Cardiologia (SBC) instacron:SBC |
instname_str |
Sociedade Brasileira de Cardiologia (SBC) |
instacron_str |
SBC |
institution |
SBC |
reponame_str |
International Journal of Cardiovascular Sciences (Online) |
collection |
International Journal of Cardiovascular Sciences (Online) |
repository.name.fl_str_mv |
International Journal of Cardiovascular Sciences (Online) - Sociedade Brasileira de Cardiologia (SBC) |
repository.mail.fl_str_mv |
tailanerodrigues@cardiol.br||revistaijcs@cardiol.br |
_version_ |
1754732627396395008 |