CELL THERAPY IN THE TREATMENT OF INTERVERTEBRAL DISC DEGENERATION

Detalhes bibliográficos
Autor(a) principal: Campos,Marcelo Ferraz
Data de Publicação: 2021
Outros Autores: Silva,Mariane de Barros Ribeiro da, Pinhal,Maria Aparecida Silva, Salati,Thiago, Rodrigues,Luciano Miller Reis, Melo,Carina Mucciolo
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Coluna/Columna
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1808-18512021000200101
Resumo: ABSTRACT Approximately 80% of the world population experiences some type of back pain at some point in their life, and in 10% of this population the pain causes chronic disability resulting in a high cost for the treatment of these patients, in addition to compromising their work and social interaction abilities. Current treatment strategies include the surgical procedure for degenerated intervertebral disc resection, the nerve root block and physiotherapy. However, such treatments only relieve symptoms and do not prevent the degeneration of intervertebral discs. Therefore, new therapeutic strategies have emerged and include manipulating cells to recover the degenerated disc. This article will discuss the possible cell therapy alternatives used in the disc regeneration process, featuring a descriptive study of translational medicine that involves clinical aspects of new treatment alternatives and knowledge of basic research areas, such as cellular and molecular biology. Level of evidence V; Expert Opinion.
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spelling CELL THERAPY IN THE TREATMENT OF INTERVERTEBRAL DISC DEGENERATIONIntervertebral DiscCell TherapyTridimensional Cell CultureABSTRACT Approximately 80% of the world population experiences some type of back pain at some point in their life, and in 10% of this population the pain causes chronic disability resulting in a high cost for the treatment of these patients, in addition to compromising their work and social interaction abilities. Current treatment strategies include the surgical procedure for degenerated intervertebral disc resection, the nerve root block and physiotherapy. However, such treatments only relieve symptoms and do not prevent the degeneration of intervertebral discs. Therefore, new therapeutic strategies have emerged and include manipulating cells to recover the degenerated disc. This article will discuss the possible cell therapy alternatives used in the disc regeneration process, featuring a descriptive study of translational medicine that involves clinical aspects of new treatment alternatives and knowledge of basic research areas, such as cellular and molecular biology. Level of evidence V; Expert Opinion.Sociedade Brasileira de Coluna2021-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1808-18512021000200101Coluna/Columna v.20 n.2 2021reponame:Coluna/Columnainstname:Sociedade Brasileira de Coluna (SBCO)instacron:SBCO10.1590/s1808-185120212002229178info:eu-repo/semantics/openAccessCampos,Marcelo FerrazSilva,Mariane de Barros Ribeiro daPinhal,Maria Aparecida SilvaSalati,ThiagoRodrigues,Luciano Miller ReisMelo,Carina Muccioloeng2021-05-18T00:00:00Zoai:scielo:S1808-18512021000200101Revistahttps://www.revistacoluna.org/ONGhttps://old.scielo.br/oai/scielo-oai.phpcoluna.columna@uol.com.br||revistacoluna@uol.com.br2177-014X1808-1851opendoar:2021-05-18T00:00Coluna/Columna - Sociedade Brasileira de Coluna (SBCO)false
dc.title.none.fl_str_mv CELL THERAPY IN THE TREATMENT OF INTERVERTEBRAL DISC DEGENERATION
title CELL THERAPY IN THE TREATMENT OF INTERVERTEBRAL DISC DEGENERATION
spellingShingle CELL THERAPY IN THE TREATMENT OF INTERVERTEBRAL DISC DEGENERATION
Campos,Marcelo Ferraz
Intervertebral Disc
Cell Therapy
Tridimensional Cell Culture
title_short CELL THERAPY IN THE TREATMENT OF INTERVERTEBRAL DISC DEGENERATION
title_full CELL THERAPY IN THE TREATMENT OF INTERVERTEBRAL DISC DEGENERATION
title_fullStr CELL THERAPY IN THE TREATMENT OF INTERVERTEBRAL DISC DEGENERATION
title_full_unstemmed CELL THERAPY IN THE TREATMENT OF INTERVERTEBRAL DISC DEGENERATION
title_sort CELL THERAPY IN THE TREATMENT OF INTERVERTEBRAL DISC DEGENERATION
author Campos,Marcelo Ferraz
author_facet Campos,Marcelo Ferraz
Silva,Mariane de Barros Ribeiro da
Pinhal,Maria Aparecida Silva
Salati,Thiago
Rodrigues,Luciano Miller Reis
Melo,Carina Mucciolo
author_role author
author2 Silva,Mariane de Barros Ribeiro da
Pinhal,Maria Aparecida Silva
Salati,Thiago
Rodrigues,Luciano Miller Reis
Melo,Carina Mucciolo
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Campos,Marcelo Ferraz
Silva,Mariane de Barros Ribeiro da
Pinhal,Maria Aparecida Silva
Salati,Thiago
Rodrigues,Luciano Miller Reis
Melo,Carina Mucciolo
dc.subject.por.fl_str_mv Intervertebral Disc
Cell Therapy
Tridimensional Cell Culture
topic Intervertebral Disc
Cell Therapy
Tridimensional Cell Culture
description ABSTRACT Approximately 80% of the world population experiences some type of back pain at some point in their life, and in 10% of this population the pain causes chronic disability resulting in a high cost for the treatment of these patients, in addition to compromising their work and social interaction abilities. Current treatment strategies include the surgical procedure for degenerated intervertebral disc resection, the nerve root block and physiotherapy. However, such treatments only relieve symptoms and do not prevent the degeneration of intervertebral discs. Therefore, new therapeutic strategies have emerged and include manipulating cells to recover the degenerated disc. This article will discuss the possible cell therapy alternatives used in the disc regeneration process, featuring a descriptive study of translational medicine that involves clinical aspects of new treatment alternatives and knowledge of basic research areas, such as cellular and molecular biology. Level of evidence V; Expert Opinion.
publishDate 2021
dc.date.none.fl_str_mv 2021-06-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1808-18512021000200101
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1808-18512021000200101
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/s1808-185120212002229178
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Coluna
publisher.none.fl_str_mv Sociedade Brasileira de Coluna
dc.source.none.fl_str_mv Coluna/Columna v.20 n.2 2021
reponame:Coluna/Columna
instname:Sociedade Brasileira de Coluna (SBCO)
instacron:SBCO
instname_str Sociedade Brasileira de Coluna (SBCO)
instacron_str SBCO
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reponame_str Coluna/Columna
collection Coluna/Columna
repository.name.fl_str_mv Coluna/Columna - Sociedade Brasileira de Coluna (SBCO)
repository.mail.fl_str_mv coluna.columna@uol.com.br||revistacoluna@uol.com.br
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