CELL THERAPY IN THE TREATMENT OF INTERVERTEBRAL DISC DEGENERATION

• Main Author: Campos,Marcelo Ferraz
• Publication Date: 2021
• Other Authors: Silva,Mariane de Barros Ribeiro da, Pinhal,Maria Aparecida Silva, Salati,Thiago, Rodrigues,Luciano Miller Reis, Melo,Carina Mucciolo
• Format: Article
• Language: eng
• Source: Coluna/Columna
• Download full: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1808-18512021000200101
• topic: Intervertebral Disc; Cell Therapy; Tridimensional Cell Culture

ABSTRACT Approximately 80% of the world population experiences some type of back pain at some point in their life, and in 10% of this population the pain causes chronic disability resulting in a high cost for the treatment of these patients, in addition to compromising their work and social interaction abilities. Current treatment strategies include the surgical procedure for degenerated intervertebral disc resection, the nerve root block and physiotherapy. However, such treatments only relieve symptoms and do not prevent the degeneration of intervertebral discs. Therefore, new therapeutic strategies have emerged and include manipulating cells to recover the degenerated disc. This article will discuss the possible cell therapy alternatives used in the disc regeneration process, featuring a descriptive study of translational medicine that involves clinical aspects of new treatment alternatives and knowledge of basic research areas, such as cellular and molecular biology. Level of evidence V; Expert Opinion.