Langerhans’ cell histiocytosis diagnosed due to dermatological perianal lesion
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , , |
Tipo de documento: | Relatório |
Idioma: | eng |
Título da fonte: | Journal of Coloproctology (Rio de Janeiro. Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S2237-93632017000300242 |
Resumo: | Abstract Langerhans’ cell histiocytosis is a rare disease characterized by proliferation of Langerhans cells in the body. It affects mainly males, predominantly in childhood. Ulcerated plaques are one of the cutaneous forms of presentation. Diagnostic confirmation is done through immunohistochemistry. As therapeutic options, topical corticosteroids and chemotherapy are good choices. The case is reported of a male patient, aged 14, with perianal ulceration. He consulted a coloproctologist, who performed a biopsy of the region and started local triamcinolone applications. Immunohistochemistry diagnosed Langerhans’ cells histiocytosis. Further investigation revealed diabetes insipidus, osteolytic lesions in the skull and lower limbs, enlarged liver, and encephalic alterations. Chemotherapy was started with Vinblastine, with significant improvement of the lesions. |
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Langerhans’ cell histiocytosis diagnosed due to dermatological perianal lesionCD1 antigensLangerhans’ cellsLangerhans’ cell histiocytosisHistiocytosis XVinblastineAbstract Langerhans’ cell histiocytosis is a rare disease characterized by proliferation of Langerhans cells in the body. It affects mainly males, predominantly in childhood. Ulcerated plaques are one of the cutaneous forms of presentation. Diagnostic confirmation is done through immunohistochemistry. As therapeutic options, topical corticosteroids and chemotherapy are good choices. The case is reported of a male patient, aged 14, with perianal ulceration. He consulted a coloproctologist, who performed a biopsy of the region and started local triamcinolone applications. Immunohistochemistry diagnosed Langerhans’ cells histiocytosis. Further investigation revealed diabetes insipidus, osteolytic lesions in the skull and lower limbs, enlarged liver, and encephalic alterations. Chemotherapy was started with Vinblastine, with significant improvement of the lesions.Sociedade Brasileira de Coloproctologia2017-09-01info:eu-repo/semantics/reportinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S2237-93632017000300242Journal of Coloproctology (Rio de Janeiro) v.37 n.3 2017reponame:Journal of Coloproctology (Rio de Janeiro. Online)instname:Sociedade Brasileira de Coloproctologia (SBCP)instacron:SBCP10.1016/j.jcol.2017.03.007info:eu-repo/semantics/openAccessScolaro,Bruno LorenzoPereira,Gustavo BeckerOgata,Daniel CuryCunha,Fernanda Souto Padrón Figueiredo Vieira daEffting,Ana Cristina MartinsGuanabara,Rafael Oselameeng2017-08-23T00:00:00Zoai:scielo:S2237-93632017000300242Revistahttp://www.scielo.br/scielo.php?script=sci_serial&pid=2237-9363&lng=pt&nrm=isohttps://old.scielo.br/oai/scielo-oai.php||sbcp@sbcp.org.br2317-64232237-9363opendoar:2017-08-23T00:00Journal of Coloproctology (Rio de Janeiro. Online) - Sociedade Brasileira de Coloproctologia (SBCP)false |
dc.title.none.fl_str_mv |
Langerhans’ cell histiocytosis diagnosed due to dermatological perianal lesion |
title |
Langerhans’ cell histiocytosis diagnosed due to dermatological perianal lesion |
spellingShingle |
Langerhans’ cell histiocytosis diagnosed due to dermatological perianal lesion Scolaro,Bruno Lorenzo CD1 antigens Langerhans’ cells Langerhans’ cell histiocytosis Histiocytosis X Vinblastine |
title_short |
Langerhans’ cell histiocytosis diagnosed due to dermatological perianal lesion |
title_full |
Langerhans’ cell histiocytosis diagnosed due to dermatological perianal lesion |
title_fullStr |
Langerhans’ cell histiocytosis diagnosed due to dermatological perianal lesion |
title_full_unstemmed |
Langerhans’ cell histiocytosis diagnosed due to dermatological perianal lesion |
title_sort |
Langerhans’ cell histiocytosis diagnosed due to dermatological perianal lesion |
author |
Scolaro,Bruno Lorenzo |
author_facet |
Scolaro,Bruno Lorenzo Pereira,Gustavo Becker Ogata,Daniel Cury Cunha,Fernanda Souto Padrón Figueiredo Vieira da Effting,Ana Cristina Martins Guanabara,Rafael Oselame |
author_role |
author |
author2 |
Pereira,Gustavo Becker Ogata,Daniel Cury Cunha,Fernanda Souto Padrón Figueiredo Vieira da Effting,Ana Cristina Martins Guanabara,Rafael Oselame |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Scolaro,Bruno Lorenzo Pereira,Gustavo Becker Ogata,Daniel Cury Cunha,Fernanda Souto Padrón Figueiredo Vieira da Effting,Ana Cristina Martins Guanabara,Rafael Oselame |
dc.subject.por.fl_str_mv |
CD1 antigens Langerhans’ cells Langerhans’ cell histiocytosis Histiocytosis X Vinblastine |
topic |
CD1 antigens Langerhans’ cells Langerhans’ cell histiocytosis Histiocytosis X Vinblastine |
description |
Abstract Langerhans’ cell histiocytosis is a rare disease characterized by proliferation of Langerhans cells in the body. It affects mainly males, predominantly in childhood. Ulcerated plaques are one of the cutaneous forms of presentation. Diagnostic confirmation is done through immunohistochemistry. As therapeutic options, topical corticosteroids and chemotherapy are good choices. The case is reported of a male patient, aged 14, with perianal ulceration. He consulted a coloproctologist, who performed a biopsy of the region and started local triamcinolone applications. Immunohistochemistry diagnosed Langerhans’ cells histiocytosis. Further investigation revealed diabetes insipidus, osteolytic lesions in the skull and lower limbs, enlarged liver, and encephalic alterations. Chemotherapy was started with Vinblastine, with significant improvement of the lesions. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-09-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/report |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
report |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S2237-93632017000300242 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S2237-93632017000300242 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1016/j.jcol.2017.03.007 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Coloproctologia |
publisher.none.fl_str_mv |
Sociedade Brasileira de Coloproctologia |
dc.source.none.fl_str_mv |
Journal of Coloproctology (Rio de Janeiro) v.37 n.3 2017 reponame:Journal of Coloproctology (Rio de Janeiro. Online) instname:Sociedade Brasileira de Coloproctologia (SBCP) instacron:SBCP |
instname_str |
Sociedade Brasileira de Coloproctologia (SBCP) |
instacron_str |
SBCP |
institution |
SBCP |
reponame_str |
Journal of Coloproctology (Rio de Janeiro. Online) |
collection |
Journal of Coloproctology (Rio de Janeiro. Online) |
repository.name.fl_str_mv |
Journal of Coloproctology (Rio de Janeiro. Online) - Sociedade Brasileira de Coloproctologia (SBCP) |
repository.mail.fl_str_mv |
||sbcp@sbcp.org.br |
_version_ |
1752126478223409152 |